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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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- Product number
- HPA023314 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA023314, RRID:AB_1856830
- Product name
- Anti-SHMT1
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human SHMT1, Gene description: serine hydroxymethyltransferase 1 (soluble), Alternative Gene Names: CSHMT, MGC15229, MGC24556, SHMT, Validated applications: ICC, IHC, WB, Uniprot ID: P34896, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.1 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.
Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis
Folate can promote the methionine-dependent reprogramming of glioblastoma cells towards pluripotency
Increased formate overflow is a hallmark of oxidative cancer
Mouse Genetics Suggests Cell-Context Dependency for Myc-Regulated Metabolic Enzymes during Tumorigenesis
Green AC, Marttila P, Kiweler N, Chalkiadaki C, Wiita E, Cookson V, Lesur A, Eiden K, Bernardin F, Vallin KSA, Borhade S, Long M, Ghahe EK, Jiménez-Alonso JJ, Jemth AS, Loseva O, Mortusewicz O, Meyers M, Viry E, Johansson AI, Hodek O, Homan E, Bonagas N, Ramos L, Sandberg L, Frödin M, Moussay E, Slipicevic A, Letellier E, Paggetti J, Sørensen CS, Helleday T, Henriksson M, Meiser J
Nature metabolism 2023 Apr;5(4):642-659
Nature metabolism 2023 Apr;5(4):642-659
Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis
Kiweler N, Delbrouck C, Pozdeev V, Neises L, Soriano-Baguet L, Eiden K, Xian F, Benzarti M, Haase L, Koncina E, Schmoetten M, Jaeger C, Noman M, Vazquez A, Janji B, Dittmar G, Brenner D, Letellier E, Meiser J
Nature Communications 2022;13(1)
Nature Communications 2022;13(1)
Folate can promote the methionine-dependent reprogramming of glioblastoma cells towards pluripotency
Zgheib R, Battaglia-Hsu S, Hergalant S, Quéré M, Alberto J, Chéry C, Rouyer P, Gauchotte G, Guéant J, Namour F
Cell Death & Disease 2019;10(8)
Cell Death & Disease 2019;10(8)
Increased formate overflow is a hallmark of oxidative cancer
Meiser J, Schuster A, Pietzke M, Vande Voorde J, Athineos D, Oizel K, Burgos-Barragan G, Wit N, Dhayade S, Morton J, Dornier E, Sumpton D, Mackay G, Blyth K, Patel K, Niclou S, Vazquez A
Nature Communications 2018;9(1)
Nature Communications 2018;9(1)
Mouse Genetics Suggests Cell-Context Dependency for Myc-Regulated Metabolic Enzymes during Tumorigenesis
Clurman B, Nilsson L, Plym Forshell T, Rimpi S, Kreutzer C, Pretsch W, Bornkamm G, Nilsson J
PLoS Genetics 2012;8(3):e1002573
PLoS Genetics 2012;8(3):e1002573
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Supportive validation
- Submitted by
- Atlas Antibodies (provider)
- Enhanced method
- Orthogonal validation
- Main image
- Experimental details
- Immunohistochemistry analysis in human kidney and skeletal muscle tissues using HPA023314 antibody. Corresponding SHMT1 RNA-seq data are presented for the same tissues.
- Sample type
- Human
- Protocol
- Protocol
