SHMT1

This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Description

serine hydroxymethyltransferase 1

Protein family

Enzymes, FDA approved drug targets, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

17:p11.2 (18327860 - 18363563)

Ensembl ID

ENSG00000176974  (ver. 99.38)

Orthologs

Mouse Shmt1: ENSMUSG00000020534

UniProt

P34896

neXtProt

NX_P34896

Human splice variants
Mouse splice variants