Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Immunohistochemistry [1]
- Blocking/Neutralizing [1]
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Validation data
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- Product number
- AF459 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal Osteoprotegerin/TNFRSF11B Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects mouse Osteoprotegerin in direct ELISAs and Western blots. In direct ELISAs, approximately 40% cross-reactivity with recombinant human Osteoprotegerin is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Role of osteoprotegerin in the regulation of dental epithelial‑mesenchymal signaling during tooth development.
A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension.
Dimerization interface of osteoprotegerin revealed by hydrogen-deuterium exchange mass spectrometry.
Morc3 mutant mice exhibit reduced cortical area and thickness, accompanied by altered haematopoietic stem cells niche and bone cell differentiation.
TRAIL stimulates proliferation of vascular smooth muscle cells via activation of NF-kappaB and induction of insulin-like growth factor-1 receptor.
JunB as a downstream mediator of PTHrP actions in cementoblasts.
Bacteria induce osteoclastogenesis via an osteoblast-independent pathway.
Bacteria induce osteoclastogenesis via an osteoblast-independent pathway.
Estrogen inhibition of PTH-stimulated osteoclast formation and attachment in vitro: involvement of both PKA and PKC.
Gao X, Zheng J, Tu S, Cai B, Zeng R, Xiang L
Molecular medicine reports 2019 Oct;20(4):3035-3042
Molecular medicine reports 2019 Oct;20(4):3035-3042
A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension.
Arnold ND, Pickworth JA, West LE, Dawson S, Carvalho JA, Casbolt H, Braithwaite AT, Iremonger J, Renshall L, Germaschewski V, McCourt M, Bland-Ward P, Kowash H, Hameed AG, Rothman AMK, Frid MG, Roger Thompson AA, Evans HR, Southwood M, Morrell NW, Crossman DC, Whyte MKB, Stenmark KR, Newman CM, Kiely DG, Francis SE, Lawrie A
Nature communications 2019 Nov 15;10(1):5183
Nature communications 2019 Nov 15;10(1):5183
Dimerization interface of osteoprotegerin revealed by hydrogen-deuterium exchange mass spectrometry.
Xiao Y, Li M, Larocque R, Zhang F, Malhotra A, Chen J, Linhardt RJ, Konermann L, Xu D
The Journal of biological chemistry 2018 Nov 9;293(45):17523-17535
The Journal of biological chemistry 2018 Nov 9;293(45):17523-17535
Morc3 mutant mice exhibit reduced cortical area and thickness, accompanied by altered haematopoietic stem cells niche and bone cell differentiation.
Jadhav G, Teguh D, Kenny J, Tickner J, Xu J
Scientific reports 2016 May 18;6:25964
Scientific reports 2016 May 18;6:25964
TRAIL stimulates proliferation of vascular smooth muscle cells via activation of NF-kappaB and induction of insulin-like growth factor-1 receptor.
Kavurma MM, Schoppet M, Bobryshev YV, Khachigian LM, Bennett MR
The Journal of biological chemistry 2008 Mar 21;283(12):7754-62
The Journal of biological chemistry 2008 Mar 21;283(12):7754-62
JunB as a downstream mediator of PTHrP actions in cementoblasts.
Berry JE, Ealba EL, Pettway GJ, Datta NS, Swanson EC, Somerman MJ, McCauley LK
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006 Feb;21(2):246-57
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006 Feb;21(2):246-57
Bacteria induce osteoclastogenesis via an osteoblast-independent pathway.
Jiang Y, Mehta CK, Hsu TY, Alsulaimani FF
Infection and immunity 2002 Jun;70(6):3143-8
Infection and immunity 2002 Jun;70(6):3143-8
Bacteria induce osteoclastogenesis via an osteoblast-independent pathway.
Jiang Y, Mehta CK, Hsu TY, Alsulaimani FF
Infection and immunity 2002 Jun;70(6):3143-8
Infection and immunity 2002 Jun;70(6):3143-8
Estrogen inhibition of PTH-stimulated osteoclast formation and attachment in vitro: involvement of both PKA and PKC.
Liu BY, Wu PW, Bringhurst FR, Wang JT
Endocrinology 2002 Feb;143(2):627-35
Endocrinology 2002 Feb;143(2):627-35
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Osteoprotegerin/TNFRSF11B in Mouse Stomach. Osteoprotegerin/TNFRSF11B in Mouse Stomach.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Osteoprotegerin/TNFRSF11B Inhibition of TRAIL/TNFSF10-induced Cytotoxicity and Neutralization by Mouse Osteoprotegerin/TNFRSF11B Antibody. Osteoprotegerin/TNFRSF11B Inhibition of TRAIL/TNFSF10-induced Cytotoxicity and Neutralization by Mouse Osteoprotegerin/TNFRSF11B Antibody.