Tissue expression
Cell line expression
Protein structure
MADD
MAP kinase activating death domainDENN, KIAA0358, RAB3GEP
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Top validated antibodies |
|||||
antibodies-online | ABIN500216 | 4 references | Polyclonal |
WB
EL
ICC
|
|
Aviva Systems Biology | OAAF02577 | Polyclonal |
WB
EL
ICC
IHC |
||
Invitrogen Antibodies | A302-144A | Polyclonal |
WB
IP
IHC
OA |
||
Cusabio Biotech Co., Ltd | CSB-PA003185 | Polyclonal |
WB
EL
ICC
IHC |
||
Affinity Biosciences | DF3374 | Polyclonal |
WB
EL
ICC
IHC |
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider