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- Product number
- 17548-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17548-1-AP, RRID:AB_2116926
- Product name
- HDAC8 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HDAC8 antibody (Cat. #17548-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A novel HDAC8 inhibitor H7E exerts retinoprotective effects against glaucomatous injury via ameliorating aberrant Müller glia activation and oxidative stress.
Anti-Colorectal Cancer Activity of Solasonin from Solanum nigrum L. via Histone Deacetylases-Mediated p53 Acetylation Pathway.
HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation.
Gut microbiota shapes social dominance through modulating HDAC2 in the medial prefrontal cortex.
HDAC1 promotes the migration of human myeloma cells via regulation of the lncRNA/Slug axis.
Selective HDAC8 Inhibition Attenuates Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis via p38 MAPK Pathway.
USP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3.
HDAC3 and HDAC8 are required for cilia assembly and elongation.
Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem-Like Cells In Vivo.
Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors.
Curcumin Derivative Epigenetically Reactivates Nrf2 Antioxidative Stress Signaling in Mouse Prostate Cancer TRAMP C1 Cells.
The triterpenoid corosolic acid blocks transformation and epigenetically reactivates Nrf2 in TRAMP-C1 prostate cells.
Epigenetic modifications of triterpenoid ursolic acid in activating Nrf2 and blocking cellular transformation of mouse epidermal cells.
Thrombospondin-1 might be a therapeutic target to suppress RB cells by regulating the DNA double-strand breaks repair.
Epigenetics Reactivation of Nrf2 in Prostate TRAMP C1 Cells by Curcumin Analogue FN1.
Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1.
Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.
Apigenin reactivates Nrf2 anti-oxidative stress signaling in mouse skin epidermal JB6 P + cells through epigenetics modifications.
Downregulation of histone deacetylase 1 by microRNA-520h contributes to the chemotherapeutic effect of doxorubicin.
Epigenetic modifications of Nrf2 by 3,3'-diindolylmethane in vitro in TRAMP C1 cell line and in vivo TRAMP prostate tumors.
Epigenetic CpG demethylation of the promoter and reactivation of the expression of Neurog1 by curcumin in prostate LNCaP cells.
Wu LH, Cheng YW, Lin FL, Hsu KC, Wang MH, Yen JL, Wang TJ, Lin TE, Liu YC, Huang WJ, Hsiao G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116538
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116538
Anti-Colorectal Cancer Activity of Solasonin from Solanum nigrum L. via Histone Deacetylases-Mediated p53 Acetylation Pathway.
Lan X, Lu M, Fang X, Cao Y, Sun M, Shan M, Gao W, Wang Y, Yu W, Luo H
Molecules (Basel, Switzerland) 2023 Sep 15;28(18)
Molecules (Basel, Switzerland) 2023 Sep 15;28(18)
HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation.
Xiao Y, Hale S, Awasthee N, Meng C, Zhang X, Liu Y, Ding H, Huo Z, Lv D, Zhang W, He M, Zheng G, Liao D
Cell chemical biology 2023 Nov 16;30(11):1421-1435.e12
Cell chemical biology 2023 Nov 16;30(11):1421-1435.e12
Gut microbiota shapes social dominance through modulating HDAC2 in the medial prefrontal cortex.
Wang T, Xu J, Xu Y, Xiao J, Bi N, Gu X, Wang HL
Cell reports 2022 Mar 8;38(10):110478
Cell reports 2022 Mar 8;38(10):110478
HDAC1 promotes the migration of human myeloma cells via regulation of the lncRNA/Slug axis.
Zheng L, Zhang A, Liu J, Liu M, Zhang Y
International journal of molecular medicine 2022 Jan;49(1)
International journal of molecular medicine 2022 Jan;49(1)
Selective HDAC8 Inhibition Attenuates Isoproterenol-Induced Cardiac Hypertrophy and Fibrosis via p38 MAPK Pathway.
Zhao T, Kee HJ, Bai L, Kim MK, Kee SJ, Jeong MH
Frontiers in pharmacology 2021;12:677757
Frontiers in pharmacology 2021;12:677757
USP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3.
Zhan W, Liao X, Liu J, Tian T, Yu L, Li R
Oncogenesis 2020 May 13;9(5):48
Oncogenesis 2020 May 13;9(5):48
HDAC3 and HDAC8 are required for cilia assembly and elongation.
Park SA, Yoo H, Seol JH, Rhee K
Biology open 2019 Aug 9;8(8)
Biology open 2019 Aug 9;8(8)
Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem-Like Cells In Vivo.
Wang D, Li W, Zhao R, Chen L, Liu N, Tian Y, Zhao H, Xie M, Lu F, Fang Q, Liang W, Yin F, Li Z
Cancer research 2019 Apr 15;79(8):1769-1783
Cancer research 2019 Apr 15;79(8):1769-1783
Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors.
Huang X, Yan J, Zhang M, Wang Y, Chen Y, Fu X, Wei R, Zheng XL, Liu Z, Zhang X, Yang H, Hao B, Shen YY, Su Y, Cong X, Huang M, Tan M, Ding J, Geng M
Cell 2018 Sep 20;175(1):186-199.e19
Cell 2018 Sep 20;175(1):186-199.e19
Curcumin Derivative Epigenetically Reactivates Nrf2 Antioxidative Stress Signaling in Mouse Prostate Cancer TRAMP C1 Cells.
Li W, Su ZY, Guo Y, Zhang C, Wu R, Gao L, Zheng X, Du ZY, Zhang K, Kong AN
Chemical research in toxicology 2018 Feb 19;31(2):88-96
Chemical research in toxicology 2018 Feb 19;31(2):88-96
The triterpenoid corosolic acid blocks transformation and epigenetically reactivates Nrf2 in TRAMP-C1 prostate cells.
Yang J, Wu R, Li W, Gao L, Yang Y, Li P, Kong AN
Molecular carcinogenesis 2018 Apr;57(4):512-521
Molecular carcinogenesis 2018 Apr;57(4):512-521
Epigenetic modifications of triterpenoid ursolic acid in activating Nrf2 and blocking cellular transformation of mouse epidermal cells.
Kim H, Ramirez CN, Su ZY, Kong AN
The Journal of nutritional biochemistry 2016 Jul;33:54-62
The Journal of nutritional biochemistry 2016 Jul;33:54-62
Thrombospondin-1 might be a therapeutic target to suppress RB cells by regulating the DNA double-strand breaks repair.
Chen P, Yu N, Zhang Z, Zhang P, Yang Y, Wu N, Xu L, Zhang J, Ge J, Yu K, Zhuang J
Oncotarget 2016 Feb 2;7(5):6105-20
Oncotarget 2016 Feb 2;7(5):6105-20
Epigenetics Reactivation of Nrf2 in Prostate TRAMP C1 Cells by Curcumin Analogue FN1.
Li W, Pung D, Su ZY, Guo Y, Zhang C, Yang AY, Zheng X, Du ZY, Zhang K, Kong AN
Chemical research in toxicology 2016 Apr 18;29(4):694-703
Chemical research in toxicology 2016 Apr 18;29(4):694-703
Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1.
Guo Y, Shu L, Zhang C, Su ZY, Kong AN
Biochemical pharmacology 2015 Mar 15;94(2):69-78
Biochemical pharmacology 2015 Mar 15;94(2):69-78
Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.
Wang X, Liu J, Zhen J, Zhang C, Wan Q, Liu G, Wei X, Zhang Y, Wang Z, Han H, Xu H, Bao C, Song Z, Zhang X, Li N, Yi F
Kidney international 2014 Oct;86(4):712-25
Kidney international 2014 Oct;86(4):712-25
Apigenin reactivates Nrf2 anti-oxidative stress signaling in mouse skin epidermal JB6 P + cells through epigenetics modifications.
Paredes-Gonzalez X, Fuentes F, Su ZY, Kong AN
The AAPS journal 2014 Jul;16(4):727-35
The AAPS journal 2014 Jul;16(4):727-35
Downregulation of histone deacetylase 1 by microRNA-520h contributes to the chemotherapeutic effect of doxorubicin.
Shen Q, Yao Q, Sun J, Feng L, Lu H, Ma Y, Liu L, Wang F, Li J, Yue Y, Jin H, Wang X
FEBS letters 2014 Jan 3;588(1):184-91
FEBS letters 2014 Jan 3;588(1):184-91
Epigenetic modifications of Nrf2 by 3,3'-diindolylmethane in vitro in TRAMP C1 cell line and in vivo TRAMP prostate tumors.
Wu TY, Khor TO, Su ZY, Saw CL, Shu L, Cheung KL, Huang Y, Yu S, Kong AN
The AAPS journal 2013 Jul;15(3):864-74
The AAPS journal 2013 Jul;15(3):864-74
Epigenetic CpG demethylation of the promoter and reactivation of the expression of Neurog1 by curcumin in prostate LNCaP cells.
Shu L, Khor TO, Lee JH, Boyanapalli SS, Huang Y, Wu TY, Saw CL, Cheung KL, Kong AN
The AAPS journal 2011 Dec;13(4):606-14
The AAPS journal 2011 Dec;13(4):606-14
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Supportive validation
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- Proteintech Group (provider)
- Main image
- Experimental details
- The HDAC8 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HDAC8. This antibody recognizes human, mouse, rat antigen. The HDAC8 antibody has been validated for the following applications: ELISA, WB analysis.
