ARPC1B

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011]

Description

Actin related protein 2/3 complex subunit 1B

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Vesicles, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7:q22.1 (99374249 - 99394816)

Ensembl ID

ENSG00000130429  (ver. 103.38)

Orthologs

Mouse Arpc1b: ENSMUSG00000029622

UniProt

O15143

neXtProt

NX_O15143

Human splice variants
Mouse splice variants