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- References [21]
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- Product number
- 10390-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10390-1-AP, RRID:AB_2118914
- Product name
- HGS antibody
- Antibody type
- Polyclonal
- Description
- HGS antibody (Cat. #10390-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The lipid-metabolic enzyme HSD17B12 drives lysosomal degradation of PD-L1 potentiating anti-tumor immunity in a mouse model.
Dual roles of CXCR4 (C-X-C motif chemokine receptor 4) in promoting entry of ebolavirus and targeting excessive glycoprotein for reticulophagic degradation to facilitate viral fitness.
KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia.
Munc13-4 mediates tumor immune evasion by regulating the sorting and secretion of PD-L1 via exosomes.
Endosome maturation during ER stress relies on the ubiquitin-binding domain of histone deacetylase 6.
Serine/threonine/tyrosine kinase 1 drives pancreatic carcinogenesis via GSK3β sequestration-mediated Wnt/β-catenin pathway hyperactivation.
Glutamine binds HSC70 to transduce signals inhibiting IFN-β-mediated immunogenic cell death.
The USP12/46 deubiquitinases protect integrins from ESCRT-mediated lysosomal degradation.
Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration.
GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis.
Enterovirus 71 non-structural protein 3A hijacks vacuolar protein sorting 25 to boost exosome biogenesis to facilitate viral replication.
A natural halogenated fluoride adenosine analog 5'-fluorodeoxy adenosine induced anticolon cancer activity in vivo and in vitro.
Human Cytomegalovirus Hijacks WD Repeat Domain 11 for Virion Assembly Compartment Formation and Virion Morphogenesis.
Neutral sphingomyelinase 2 controls exosome secretion by counteracting V-ATPase-mediated endosome acidification.
Compartmentalization of casein kinase 1 γ CSNK1G controls the intracellular trafficking of ceramide.
VPS28 regulates brain vasculature by controlling neuronal VEGF trafficking through extracellular vesicle secretion.
Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes.
The interferon-stimulated exosomal hACE2 potently inhibits SARS-CoV-2 replication through competitively blocking the virus entry.
RAB31 marks and controls an ESCRT-independent exosome pathway.
β-defensin 1 expression in HCV infected liver/liver cancer: an important role in protecting HCV progression and liver cancer development.
The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4.
Zhou Z, Lu Y, Li P, Liu X, Cheng W, Chen HN, Dai L, Ren H
PLoS biology 2026 Jan;24(1):e3003603
PLoS biology 2026 Jan;24(1):e3003603
Dual roles of CXCR4 (C-X-C motif chemokine receptor 4) in promoting entry of ebolavirus and targeting excessive glycoprotein for reticulophagic degradation to facilitate viral fitness.
Huang H, Shi W, Yan H, Fan L, Lu J, Long Z, Li X, Li J, Wang J, Liu L, Qian J
Autophagy 2025 Oct;21(10):2148-2167
Autophagy 2025 Oct;21(10):2148-2167
KIF13B controls ciliary protein content by promoting endocytic retrieval and suppressing release of large extracellular vesicles from cilia.
Rezi CK, Frei A, Campestre F, Boldt K, Mary B, Fixdahl AM, With Petersen AL, Sicot A, Berggreen CR, Laplace J, Johansen SL, Sørensen JKT, Chamlali M, Berchtold MW, Christensen ST, Anvarian Z, May-Simera HL, Pedersen LB
Current biology : CB 2025 Oct 6;35(19):4651-4667.e9
Current biology : CB 2025 Oct 6;35(19):4651-4667.e9
Munc13-4 mediates tumor immune evasion by regulating the sorting and secretion of PD-L1 via exosomes.
Liu C, Liu D, Zheng X, Guan J, Zhou X, Zhang H, Wang S, Li Q, Lu G, He J, Ma C
Nature communications 2025 Oct 13;16(1):9080
Nature communications 2025 Oct 13;16(1):9080
Endosome maturation during ER stress relies on the ubiquitin-binding domain of histone deacetylase 6.
Piscopo KM, Larson B, Christiansen AM, Perry JM, Hollien J
Molecular biology of the cell 2025 Oct 1;36(10):ar120
Molecular biology of the cell 2025 Oct 1;36(10):ar120
Serine/threonine/tyrosine kinase 1 drives pancreatic carcinogenesis via GSK3β sequestration-mediated Wnt/β-catenin pathway hyperactivation.
Zhou C, Dong X, Li S, Xi Y, Liu Y, Qian X, Song Z, Zhou L, Zhang R, Lyu H, Xiao S, Guo D, Zhang Q, Liu W, Xiong Y, Wang Z, Yan C, Zhang Z, Zhu H, Chen XZ, Song Z, Tang J
Signal transduction and targeted therapy 2025 Jun 30;10(1):205
Signal transduction and targeted therapy 2025 Jun 30;10(1):205
Glutamine binds HSC70 to transduce signals inhibiting IFN-β-mediated immunogenic cell death.
Zhang D, Song S, Lin J, Ye T, Yang X, Jiang Q, Mi Y, Zhang M, Ge X, Shen Y, Du P, Shi Y, Zhang X, Li L, Zhang Y, Ding L, Liu J, Zhang Y, Gao S, Ye Q
Developmental cell 2025 Jul 21;60(14):1958-1973.e9
Developmental cell 2025 Jul 21;60(14):1958-1973.e9
The USP12/46 deubiquitinases protect integrins from ESCRT-mediated lysosomal degradation.
Yu K, Wang GM, Guo SS, Bassermann F, Fässler R
EMBO reports 2024 Dec;25(12):5687-5718
EMBO reports 2024 Dec;25(12):5687-5718
Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration.
Benyair R, Giridharan SSP, Rivero-Ríos P, Hasegawa J, Bristow E, Eskelinen EL, Shmueli MD, Fishbain-Yoskovitz V, Merbl Y, Sharkey LM, Paulson HL, Hanson PI, Patnaik S, Al-Ramahi I, Botas J, Marugan J, Weisman LS
Autophagy reports 2023;2(1)
Autophagy reports 2023;2(1)
GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis.
Lee YJ, Shin KJ, Jang HJ, Ryu JS, Lee CY, Yoon JH, Seo JK, Park S, Lee S, Je AR, Huh YH, Kong SY, Kwon T, Suh PG, Chae YC
Developmental cell 2023 Feb 27;58(4):320-334.e8
Developmental cell 2023 Feb 27;58(4):320-334.e8
Enterovirus 71 non-structural protein 3A hijacks vacuolar protein sorting 25 to boost exosome biogenesis to facilitate viral replication.
Ruan Z, Liang Y, Chen Z, Yin J, Li C, Pan P, Zhang Q, Wu J, Luo Z
Frontiers in microbiology 2022;13:1024899
Frontiers in microbiology 2022;13:1024899
A natural halogenated fluoride adenosine analog 5'-fluorodeoxy adenosine induced anticolon cancer activity in vivo and in vitro.
Ma L, Liu T, Lu Y, Dong Y, Zhao X, Man S
Environmental toxicology 2022 Oct;37(10):2493-2502
Environmental toxicology 2022 Oct;37(10):2493-2502
Human Cytomegalovirus Hijacks WD Repeat Domain 11 for Virion Assembly Compartment Formation and Virion Morphogenesis.
Yang B, Yao Y, Cheng H, Wang XZ, Zhou YP, Huang SN, Ma X, Yang H, Wu J, Jiang X, Cheng S, Sun JY, Zeng WB, Chen J, Zhang FK, Shen HJ, Gu JY, McVoy MA, Britt WJ, Gong S, Luo MH
Journal of virology 2022 Mar 9;96(5):e0182721
Journal of virology 2022 Mar 9;96(5):e0182721
Neutral sphingomyelinase 2 controls exosome secretion by counteracting V-ATPase-mediated endosome acidification.
Choezom D, Gross JC
Journal of cell science 2022 Mar 1;135(5)
Journal of cell science 2022 Mar 1;135(5)
Compartmentalization of casein kinase 1 γ CSNK1G controls the intracellular trafficking of ceramide.
Goto A, Sakai S, Mizuike A, Yamaji T, Hanada K
iScience 2022 Jul 15;25(7):104624
iScience 2022 Jul 15;25(7):104624
VPS28 regulates brain vasculature by controlling neuronal VEGF trafficking through extracellular vesicle secretion.
Dong X, Jiang D, Wang L, Zhao J, Yu L, Huang Y, Wu X, Zhu Y, Zhao Y, Zhao Q, Zhang G, Li X
iScience 2022 Apr 15;25(4):104042
iScience 2022 Apr 15;25(4):104042
Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes.
Kazan JM, Desrochers G, Martin CE, Jeong H, Kharitidi D, Apaja PM, Roldan A, St Denis N, Gingras AC, Lukacs GL, Pause A
iScience 2021 Nov 19;24(11):103274
iScience 2021 Nov 19;24(11):103274
The interferon-stimulated exosomal hACE2 potently inhibits SARS-CoV-2 replication through competitively blocking the virus entry.
Zhang J, Huang F, Xia B, Yuan Y, Yu F, Wang G, Chen Q, Wang Q, Li Y, Li R, Song Z, Pan T, Chen J, Lu G, Zhang H
Signal transduction and targeted therapy 2021 May 12;6(1):189
Signal transduction and targeted therapy 2021 May 12;6(1):189
RAB31 marks and controls an ESCRT-independent exosome pathway.
Wei D, Zhan W, Gao Y, Huang L, Gong R, Wang W, Zhang R, Wu Y, Gao S, Kang T
Cell research 2021 Feb;31(2):157-177
Cell research 2021 Feb;31(2):157-177
β-defensin 1 expression in HCV infected liver/liver cancer: an important role in protecting HCV progression and liver cancer development.
Ling YM, Chen JY, Guo L, Wang CY, Tan WT, Wen Q, Zhang SD, Deng GH, Lin Y, Kwok HF
Scientific reports 2017 Oct 17;7(1):13404
Scientific reports 2017 Oct 17;7(1):13404
The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4.
Holleman J, Marchese A
Molecular biology of the cell 2014 Jun 15;25(12):1892-904
Molecular biology of the cell 2014 Jun 15;25(12):1892-904
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HGS antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HGS. This antibody recognizes human, mouse antigen. The HGS antibody has been validated for the following applications: ELISA, WB analysis.
