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LearnTissue expression
Cell line expression
HGS
gene productHrs, Vps27, ZFYVE8
The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]
- Description
- Hepatocyte growth factor-regulated tyrosine kinase substrate
- Tissue specificity
- Low tissue specificity
- Subcell location
- Endosomes, Lysosomes, Cytosol
- Predicted location
- Intracellular
- Protein family
- Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
- Chromosome
- 17:q25.3 (81683326 - 81703138)
- Ensembl ID
- ENSG00000185359 (ver. 103.38)
- Orthologs
- Mouse Hgs: ENSMUSG00000025793
- UniProt
- O14964
- neXtProt
- NX_O14964
Human splice variants
Mouse splice variants
| Ensembl | UniProt | RefSeq | Entrez |
|---|---|---|---|
|
ENSMUST00000106203 ENSMUSP00000101809 |
NP_001152800.1 NP_001152800 | Hgs 15239 | |
|
ENSMUST00000106205 ENSMUSP00000101811 |
Q99LI8.161 Q99LI8 | NP_032270.3 NP_032270 | Hgs 15239 |
|
ENSMUST00000135231 ENSMUSP00000115037 |
Hgs 15239 | ||
|
ENSMUST00000140862 ENSMUSP00000119396 |
Hgs 15239 |
* nTPM: Normalized TPM levels represent consensus gene expression calculated using two data sets. Read more
RNA data sourced from Human Protein Atlas.
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