BS4824

antibody from Bioworld Technology, Inc

Targeting: HGS Hrs, Vps27, ZFYVE8

Western blot (Data presented on provider website)

Antibody Data

Product number

BS4824

Provider

Bioworld Technology, Inc

Product name

Hrs (phospho Y216) polyclonal antibody

Antibody type

Polyclonal

Antigen

Synthetic phosphopeptide derived from human Hrs around the phosphorylation site of Tyrosine 216.

Description

Hrs is involved in intracellular trafficking and signal transduction and is associated with early endosomes. Hrs contains a phosphatidylinositol 3-phosphate-binding domain that contributes to its endosomal targeting, where Hrs co-localizes with Clathrin via a Clathrin box motif at the carboxy-terminus of Hrs. Hrs is essential for ventral folding morphogenesis and shares structual similarity to the yeast protein Vps27p, which is involved in vacuolar protein sorting. The human Hrs gene, which maps to chromosome 17q25, enodes a 777 amino acid protein. In Schwann cells, Hrs co-localizes at endosomes with the tumor suppressor protein schwannomin, suggesting a role for schwannomin in Hrs-mediated cell signaling.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.