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- References [13]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 18410-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18410-1-AP, RRID:AB_10598161
- Product name
- Granulin antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Granulin antibody (Cat. #18410-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references PGRN inhibits CD8(+)T cell recruitment and promotes breast cancer progression by up-regulating ICAM-1 on TAM.
GRN is a prognostic biomarker and correlated with immune infiltration in glioma: A study based on TCGA data.
Dysregulation of the progranulin-driven autophagy-lysosomal pathway mediates secretion of the nuclear protein TDP-43.
Progranulin promotes proliferation, migration and invasion via the PI3K/Akt signalling pathway in a model of endometriosis.
Progranulin improves neural development via the PI3K/Akt/GSK-3β pathway in the cerebellum of a VPA-induced rat model of ASD.
Abnormal spatiotemporal expression pattern of progranulin and neurodevelopment impairment in VPA-induced ASD rat model.
Involvement of Progranulin and Granulin Expression in Inflammatory Responses after Cerebral Ischemia.
Progranulin alleviates podocyte injury via regulating CAMKK/AMPK-mediated autophagy under diabetic conditions.
Progranulin is preferentially expressed in patients with psoriasis vulgaris and protects mice from psoriasis-like skin inflammation.
Anti-LeY antibody enhances therapeutic efficacy of celecoxib against gastric cancer by downregulation of MAPKs/COX-2 signaling pathway: correlation with clinical study.
A method for establishing human primary gastric epithelial cell culture from fresh surgical gastric tissues.
Mining the gastric cancer secretome: identification of GRN as a potential diagnostic marker for early gastric cancer.
Significance of PC cell-derived growth factor and cyclin D1 expression in cutaneous squamous cell carcinoma.
Zhou T, Qian H, Zhang D, Fang W, Yao M, Shi H, Chen T, Chai C, Guo B
Cancer immunology, immunotherapy : CII 2024 Mar 30;73(5):76
Cancer immunology, immunotherapy : CII 2024 Mar 30;73(5):76
GRN is a prognostic biomarker and correlated with immune infiltration in glioma: A study based on TCGA data.
Xu SM, Xiao HY, Hu ZX, Zhong XF, Zeng YJ, Wu YX, Li D, Song T
Frontiers in oncology 2023;13:1162983
Frontiers in oncology 2023;13:1162983
Dysregulation of the progranulin-driven autophagy-lysosomal pathway mediates secretion of the nuclear protein TDP-43.
Tanaka Y, Ito SI, Honma Y, Hasegawa M, Kametani F, Suzuki G, Kozuma L, Takeya K, Eto M
The Journal of biological chemistry 2023 Nov;299(11):105272
The Journal of biological chemistry 2023 Nov;299(11):105272
Progranulin promotes proliferation, migration and invasion via the PI3K/Akt signalling pathway in a model of endometriosis.
Qin R, Zheng F, Qin W, Wang J, Ma N, Tian W, Li J, Liao M, Qin A
Reproductive biomedicine online 2023 Mar;46(3):425-435
Reproductive biomedicine online 2023 Mar;46(3):425-435
Progranulin improves neural development via the PI3K/Akt/GSK-3β pathway in the cerebellum of a VPA-induced rat model of ASD.
Wang L, Chen J, Hu Y, Liao A, Zheng W, Wang X, Lan J, Shen J, Wang S, Yang F, Wang Y, Li Y, Chen D
Translational psychiatry 2022 Mar 22;12(1):114
Translational psychiatry 2022 Mar 22;12(1):114
Abnormal spatiotemporal expression pattern of progranulin and neurodevelopment impairment in VPA-induced ASD rat model.
Lan J, Hu Y, Wang X, Zheng W, Liao A, Wang S, Li Y, Wang Y, Yang F, Chen D
Neuropharmacology 2021 Sep 15;196:108689
Neuropharmacology 2021 Sep 15;196:108689
Involvement of Progranulin and Granulin Expression in Inflammatory Responses after Cerebral Ischemia.
Horinokita I, Hayashi H, Oteki R, Mizumura R, Yamaguchi T, Usui A, Yuan B, Takagi N
International journal of molecular sciences 2019 Oct 21;20(20)
International journal of molecular sciences 2019 Oct 21;20(20)
Progranulin alleviates podocyte injury via regulating CAMKK/AMPK-mediated autophagy under diabetic conditions.
Zhou D, Zhou M, Wang Z, Fu Y, Jia M, Wang X, Liu M, Zhang Y, Sun Y, Zhou Y, Lu Y, Tang W, Yi F
Journal of molecular medicine (Berlin, Germany) 2019 Nov;97(11):1507-1520
Journal of molecular medicine (Berlin, Germany) 2019 Nov;97(11):1507-1520
Progranulin is preferentially expressed in patients with psoriasis vulgaris and protects mice from psoriasis-like skin inflammation.
Huang K, Chen A, Zhang X, Song Z, Xu H, Cao J, Yin Y
Immunology 2015 Jun;145(2):279-87
Immunology 2015 Jun;145(2):279-87
Anti-LeY antibody enhances therapeutic efficacy of celecoxib against gastric cancer by downregulation of MAPKs/COX-2 signaling pathway: correlation with clinical study.
Aziz F, Yang X, Wang X, Yan Q
Journal of cancer research and clinical oncology 2015 Jul;141(7):1221-35
Journal of cancer research and clinical oncology 2015 Jul;141(7):1221-35
A method for establishing human primary gastric epithelial cell culture from fresh surgical gastric tissues.
Aziz F, Yang X, Wen Q, Yan Q
Molecular medicine reports 2015 Aug;12(2):2939-44
Molecular medicine reports 2015 Aug;12(2):2939-44
Mining the gastric cancer secretome: identification of GRN as a potential diagnostic marker for early gastric cancer.
Loei H, Tan HT, Lim TK, Lim KH, So JB, Yeoh KG, Chung MC
Journal of proteome research 2012 Mar 2;11(3):1759-72
Journal of proteome research 2012 Mar 2;11(3):1759-72
Significance of PC cell-derived growth factor and cyclin D1 expression in cutaneous squamous cell carcinoma.
Huang K, Huang C, Shan K, Chen J, Li H
Clinical and experimental dermatology 2012 Jun;37(4):411-7
Clinical and experimental dermatology 2012 Jun;37(4):411-7
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse lung tissue were subjected to SDS PAGE followed by western blot with 18410-1-AP(PCDGF,GRN antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Granulin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Granulin. This antibody recognizes human,mouse,rat antigen. The Granulin antibody has been validated for the following applications: ELISA, WB, IHC analysis.
