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- References [20]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 18410-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18410-1-AP, RRID:AB_10598161
- Product name
- Granulin antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Granulin antibody (Cat. #18410-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Sortilin is Associated with PGRN-Mediated Endoplasmic Reticulum Stress and Activation of Microglia in a Rat Model of Degenerative Cervical Myelopathy.
GRASP55 maintains lysosome function by controlling sorting of lysosomal enzymes at the Golgi.
PGRN mediates the crosstalk between ovarian cancer cells and CAFs and reshapes tumor immune microenvironment.
Progranulin (PGRN) Facilitates Anti-Inflammation and Pulpitis Repair In Vivo and In Vitro Through TNFR2/14-3-3ε Signalling Complex.
Development of novel prognostic protein signatures in ovarian cancer: Molecular structure and immune function of AQP5 protein and CTDP1 protein.
Loss of FMRP in microglia promotes degeneration of parvalbumin neurons and audiogenic seizures via progranulin insufficiency.
Rg3 inhibits hypoxia-induced tumor exosomes from boosting pancreatic cancer vasculogenic mimicry through the HIF-1α/LARS1/mTOR axis.
PGRN inhibits CD8(+)T cell recruitment and promotes breast cancer progression by up-regulating ICAM-1 on TAM.
GRN is a prognostic biomarker and correlated with immune infiltration in glioma: A study based on TCGA data.
Dysregulation of the progranulin-driven autophagy-lysosomal pathway mediates secretion of the nuclear protein TDP-43.
Progranulin promotes proliferation, migration and invasion via the PI3K/Akt signalling pathway in a model of endometriosis.
Progranulin improves neural development via the PI3K/Akt/GSK-3β pathway in the cerebellum of a VPA-induced rat model of ASD.
Abnormal spatiotemporal expression pattern of progranulin and neurodevelopment impairment in VPA-induced ASD rat model.
Involvement of Progranulin and Granulin Expression in Inflammatory Responses after Cerebral Ischemia.
Progranulin alleviates podocyte injury via regulating CAMKK/AMPK-mediated autophagy under diabetic conditions.
Progranulin is preferentially expressed in patients with psoriasis vulgaris and protects mice from psoriasis-like skin inflammation.
Anti-LeY antibody enhances therapeutic efficacy of celecoxib against gastric cancer by downregulation of MAPKs/COX-2 signaling pathway: correlation with clinical study.
A method for establishing human primary gastric epithelial cell culture from fresh surgical gastric tissues.
Mining the gastric cancer secretome: identification of GRN as a potential diagnostic marker for early gastric cancer.
Significance of PC cell-derived growth factor and cyclin D1 expression in cutaneous squamous cell carcinoma.
Lei L, Wang X, Zhang J, Zhao J
Neuromolecular medicine 2026 Apr 25;28(1)
Neuromolecular medicine 2026 Apr 25;28(1)
GRASP55 maintains lysosome function by controlling sorting of lysosomal enzymes at the Golgi.
Nüchel J, Omidi M, Fernandes SA, Tauber M, Pohl S, Plomann M, Demetriades C
EMBO reports 2026 Apr 16;
EMBO reports 2026 Apr 16;
PGRN mediates the crosstalk between ovarian cancer cells and CAFs and reshapes tumor immune microenvironment.
Ning X, Wang Y, Zhai L, Gao W, Jin Z, Iqbal H, Ur-Rehman U, Gao L, Lv M, Yuan Z, Yi Z, Wang B, Chen W, Ma R, Xiao R
International immunopharmacology 2025 Oct 30;164:115362
International immunopharmacology 2025 Oct 30;164:115362
Progranulin (PGRN) Facilitates Anti-Inflammation and Pulpitis Repair In Vivo and In Vitro Through TNFR2/14-3-3ε Signalling Complex.
Ju J, Wang C, Nie F, Tian H, Yin Q, Liu J, Wang S, Yang P, Du Y
International endodontic journal 2025 Nov;58(11):1725-1737
International endodontic journal 2025 Nov;58(11):1725-1737
Development of novel prognostic protein signatures in ovarian cancer: Molecular structure and immune function of AQP5 protein and CTDP1 protein.
Ning X, Xu W, Ma J, Chen S, Ma R
International journal of biological macromolecules 2025 May;310(Pt 3):143474
International journal of biological macromolecules 2025 May;310(Pt 3):143474
Loss of FMRP in microglia promotes degeneration of parvalbumin neurons and audiogenic seizures via progranulin insufficiency.
Li H, Choi JJ, Huang EJ, Xu B
bioRxiv : the preprint server for biology 2025 Jul 12;
bioRxiv : the preprint server for biology 2025 Jul 12;
Rg3 inhibits hypoxia-induced tumor exosomes from boosting pancreatic cancer vasculogenic mimicry through the HIF-1α/LARS1/mTOR axis.
Zhao T, Cai X, Chen H, Wang Z, Bu H, Lin S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156437
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156437
PGRN inhibits CD8(+)T cell recruitment and promotes breast cancer progression by up-regulating ICAM-1 on TAM.
Zhou T, Qian H, Zhang D, Fang W, Yao M, Shi H, Chen T, Chai C, Guo B
Cancer immunology, immunotherapy : CII 2024 Mar 30;73(5):76
Cancer immunology, immunotherapy : CII 2024 Mar 30;73(5):76
GRN is a prognostic biomarker and correlated with immune infiltration in glioma: A study based on TCGA data.
Xu SM, Xiao HY, Hu ZX, Zhong XF, Zeng YJ, Wu YX, Li D, Song T
Frontiers in oncology 2023;13:1162983
Frontiers in oncology 2023;13:1162983
Dysregulation of the progranulin-driven autophagy-lysosomal pathway mediates secretion of the nuclear protein TDP-43.
Tanaka Y, Ito SI, Honma Y, Hasegawa M, Kametani F, Suzuki G, Kozuma L, Takeya K, Eto M
The Journal of biological chemistry 2023 Nov;299(11):105272
The Journal of biological chemistry 2023 Nov;299(11):105272
Progranulin promotes proliferation, migration and invasion via the PI3K/Akt signalling pathway in a model of endometriosis.
Qin R, Zheng F, Qin W, Wang J, Ma N, Tian W, Li J, Liao M, Qin A
Reproductive biomedicine online 2023 Mar;46(3):425-435
Reproductive biomedicine online 2023 Mar;46(3):425-435
Progranulin improves neural development via the PI3K/Akt/GSK-3β pathway in the cerebellum of a VPA-induced rat model of ASD.
Wang L, Chen J, Hu Y, Liao A, Zheng W, Wang X, Lan J, Shen J, Wang S, Yang F, Wang Y, Li Y, Chen D
Translational psychiatry 2022 Mar 22;12(1):114
Translational psychiatry 2022 Mar 22;12(1):114
Abnormal spatiotemporal expression pattern of progranulin and neurodevelopment impairment in VPA-induced ASD rat model.
Lan J, Hu Y, Wang X, Zheng W, Liao A, Wang S, Li Y, Wang Y, Yang F, Chen D
Neuropharmacology 2021 Sep 15;196:108689
Neuropharmacology 2021 Sep 15;196:108689
Involvement of Progranulin and Granulin Expression in Inflammatory Responses after Cerebral Ischemia.
Horinokita I, Hayashi H, Oteki R, Mizumura R, Yamaguchi T, Usui A, Yuan B, Takagi N
International journal of molecular sciences 2019 Oct 21;20(20)
International journal of molecular sciences 2019 Oct 21;20(20)
Progranulin alleviates podocyte injury via regulating CAMKK/AMPK-mediated autophagy under diabetic conditions.
Zhou D, Zhou M, Wang Z, Fu Y, Jia M, Wang X, Liu M, Zhang Y, Sun Y, Zhou Y, Lu Y, Tang W, Yi F
Journal of molecular medicine (Berlin, Germany) 2019 Nov;97(11):1507-1520
Journal of molecular medicine (Berlin, Germany) 2019 Nov;97(11):1507-1520
Progranulin is preferentially expressed in patients with psoriasis vulgaris and protects mice from psoriasis-like skin inflammation.
Huang K, Chen A, Zhang X, Song Z, Xu H, Cao J, Yin Y
Immunology 2015 Jun;145(2):279-87
Immunology 2015 Jun;145(2):279-87
Anti-LeY antibody enhances therapeutic efficacy of celecoxib against gastric cancer by downregulation of MAPKs/COX-2 signaling pathway: correlation with clinical study.
Aziz F, Yang X, Wang X, Yan Q
Journal of cancer research and clinical oncology 2015 Jul;141(7):1221-35
Journal of cancer research and clinical oncology 2015 Jul;141(7):1221-35
A method for establishing human primary gastric epithelial cell culture from fresh surgical gastric tissues.
Aziz F, Yang X, Wen Q, Yan Q
Molecular medicine reports 2015 Aug;12(2):2939-44
Molecular medicine reports 2015 Aug;12(2):2939-44
Mining the gastric cancer secretome: identification of GRN as a potential diagnostic marker for early gastric cancer.
Loei H, Tan HT, Lim TK, Lim KH, So JB, Yeoh KG, Chung MC
Journal of proteome research 2012 Mar 2;11(3):1759-72
Journal of proteome research 2012 Mar 2;11(3):1759-72
Significance of PC cell-derived growth factor and cyclin D1 expression in cutaneous squamous cell carcinoma.
Huang K, Huang C, Shan K, Chen J, Li H
Clinical and experimental dermatology 2012 Jun;37(4):411-7
Clinical and experimental dermatology 2012 Jun;37(4):411-7
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse lung tissue were subjected to SDS PAGE followed by western blot with 18410-1-AP(PCDGF,GRN antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Granulin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Granulin. This antibody recognizes human,mouse,rat antigen. The Granulin antibody has been validated for the following applications: ELISA, WB, IHC analysis.
