Antibody data
- Antibody Data
- Antigen structure
- References [21]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- AF2557 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Sheep Polyclonal Progranulin/PGRN Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects mouse Progranulin in direct ELISAs and Western blots. In Western blots, approximately 15% cross-reactivity with recombinant human Progranulin is observed.
- Reactivity
- Mouse
- Host
- Sheep
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Coupling of terminal differentiation deficit with neurodegenerative pathology in Vps35-deficient pyramidal neurons.
Progranulin deficiency leads to reduced glucocerebrosidase activity.
Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling.
Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice.
Genetic Regulation of Neuronal Progranulin Reveals a Critical Role for the Autophagy-Lysosome Pathway.
Microglia increases the proliferation of retinal precursor cells during postnatal development.
Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity.
Progranulin deficiency leads to prolonged persistence of macrophages, accompanied with myofiber hypertrophy in regenerating muscle.
Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology.
Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis.
Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum.
Progranulin gene delivery reduces plaque burden and synaptic atrophy in a mouse model of Alzheimer's disease.
Conditional loss of progranulin in neurons is not sufficient to cause neuronal ceroid lipofuscinosis-like neuropathology in mice.
Lysosomal processing of progranulin.
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.
Progranulin promotes the retinal precursor cell proliferation and the photoreceptor differentiation in the mouse retina.
Effects of hypoxia on progranulin expression in HT22 mouse hippocampal cells.
p38 MAPK alpha mediates cytokine-induced IL-6 and MMP-3 expression in human cardiac fibroblasts.
Progranulin regulates neuronal outgrowth independent of sortilin.
Progranulin, a glycoprotein deficient in frontotemporal dementia, is a novel substrate of several protein disulfide isomerase family proteins.
Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models.
Tang FL, Zhao L, Zhao Y, Sun D, Zhu XJ, Mei L, Xiong WC
Cell death and differentiation 2020 Jul;27(7):2099-2116
Cell death and differentiation 2020 Jul;27(7):2099-2116
Progranulin deficiency leads to reduced glucocerebrosidase activity.
Zhou X, Paushter DH, Pagan MD, Kim D, Nunez Santos M, Lieberman RL, Overkleeft HS, Sun Y, Smolka MB, Hu F
PloS one 2019;14(7):e0212382
PloS one 2019;14(7):e0212382
Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling.
Wei F, Jiang Z, Sun H, Pu J, Sun Y, Wang M, Tong Q, Bi Y, Ma X, Gao GF, Liu J
PLoS pathogens 2019 Oct;15(10):e1008062
PLoS pathogens 2019 Oct;15(10):e1008062
Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice.
Wang C, Zhang L, Ndong JC, Hettinghouse A, Sun G, Chen C, Zhang C, Liu R, Liu CJ
Journal of neuroinflammation 2019 Nov 27;16(1):238
Journal of neuroinflammation 2019 Nov 27;16(1):238
Genetic Regulation of Neuronal Progranulin Reveals a Critical Role for the Autophagy-Lysosome Pathway.
Elia LP, Mason AR, Alijagic A, Finkbeiner S
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Apr 24;39(17):3332-3344
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Apr 24;39(17):3332-3344
Microglia increases the proliferation of retinal precursor cells during postnatal development.
Kuse Y, Ohuchi K, Nakamura S, Hara H, Shimazawa M
Molecular vision 2018;24:536-545
Molecular vision 2018;24:536-545
Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity.
Nicholson AM, Zhou X, Perkerson RB, Parsons TM, Chew J, Brooks M, DeJesus-Hernandez M, Finch NA, Matchett BJ, Kurti A, Jansen-West KR, Perkerson E, Daughrity L, Castanedes-Casey M, Rousseau L, Phillips V, Hu F, Gendron TF, Murray ME, Dickson DW, Fryer JD, Petrucelli L, Rademakers R
Acta neuropathologica communications 2018 May 31;6(1):42
Acta neuropathologica communications 2018 May 31;6(1):42
Progranulin deficiency leads to prolonged persistence of macrophages, accompanied with myofiber hypertrophy in regenerating muscle.
Sugihara H, Miyaji K, Yamanouchi K, Matsuwaki T, Nishihara M
The Journal of veterinary medical science 2018 Mar 2;80(2):346-353
The Journal of veterinary medical science 2018 Mar 2;80(2):346-353
Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology.
Fujita K, Chen X, Homma H, Tagawa K, Amano M, Saito A, Imoto S, Akatsu H, Hashizume Y, Kaibuchi K, Miyano S, Okazawa H
Nature communications 2018 Jan 30;9(1):433
Nature communications 2018 Jan 30;9(1):433
Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis.
Arrant AE, Onyilo VC, Unger DE, Roberson ED
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Feb 28;38(9):2341-2358
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Feb 28;38(9):2341-2358
Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum.
Uesaka N, Abe M, Konno K, Yamazaki M, Sakoori K, Watanabe T, Kao TH, Mikuni T, Watanabe M, Sakimura K, Kano M
Neuron 2018 Feb 21;97(4):796-805.e5
Neuron 2018 Feb 21;97(4):796-805.e5
Progranulin gene delivery reduces plaque burden and synaptic atrophy in a mouse model of Alzheimer's disease.
Van Kampen JM, Kay DG
PloS one 2017;12(8):e0182896
PloS one 2017;12(8):e0182896
Conditional loss of progranulin in neurons is not sufficient to cause neuronal ceroid lipofuscinosis-like neuropathology in mice.
Petkau TL, Blanco J, Leavitt BR
Neurobiology of disease 2017 Oct;106:14-22
Neurobiology of disease 2017 Oct;106:14-22
Lysosomal processing of progranulin.
Zhou X, Paushter DH, Feng T, Sun L, Reinheckel T, Hu F
Molecular neurodegeneration 2017 Aug 23;12(1):62
Molecular neurodegeneration 2017 Aug 23;12(1):62
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.
Beel S, Moisse M, Damme M, De Muynck L, Robberecht W, Van Den Bosch L, Saftig P, Van Damme P
Human molecular genetics 2017 Aug 1;26(15):2850-2863
Human molecular genetics 2017 Aug 1;26(15):2850-2863
Progranulin promotes the retinal precursor cell proliferation and the photoreceptor differentiation in the mouse retina.
Kuse Y, Tsuruma K, Sugitani S, Izawa H, Ohno Y, Shimazawa M, Hara H
Scientific reports 2016 Mar 31;6:23811
Scientific reports 2016 Mar 31;6:23811
Effects of hypoxia on progranulin expression in HT22 mouse hippocampal cells.
Luo L, Lü L, Lu Y, Zhang L, Li B, Guo K, Chen L, Wang Y, Shao Y, Xu J
Molecular medicine reports 2014 May;9(5):1675-80
Molecular medicine reports 2014 May;9(5):1675-80
p38 MAPK alpha mediates cytokine-induced IL-6 and MMP-3 expression in human cardiac fibroblasts.
Sinfield JK, Das A, O'Regan DJ, Ball SG, Porter KE, Turner NA
Biochemical and biophysical research communications 2013 Jan 4;430(1):419-24
Biochemical and biophysical research communications 2013 Jan 4;430(1):419-24
Progranulin regulates neuronal outgrowth independent of sortilin.
Gass J, Lee WC, Cook C, Finch N, Stetler C, Jansen-West K, Lewis J, Link CD, Rademakers R, Nykjær A, Petrucelli L
Molecular neurodegeneration 2012 Jul 10;7:33
Molecular neurodegeneration 2012 Jul 10;7:33
Progranulin, a glycoprotein deficient in frontotemporal dementia, is a novel substrate of several protein disulfide isomerase family proteins.
Almeida S, Zhou L, Gao FB
PloS one 2011;6(10):e26454
PloS one 2011;6(10):e26454
Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models.
Pereson S, Wils H, Kleinberger G, McGowan E, Vandewoestyne M, Van Broeck B, Joris G, Cuijt I, Deforce D, Hutton M, Van Broeckhoven C, Kumar-Singh S
The Journal of pathology 2009 Oct;219(2):173-81
The Journal of pathology 2009 Oct;219(2):173-81
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of Mouse Progranulin/PGRN by Western Blot. Detection of Mouse Progranulin/PGRN by Western Blot.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Progranulin in Mouse Kidney. Progranulin in Mouse Kidney.