Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Immunohistochemistry [5]
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- Product number
- NBP1-87324 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-87324, RRID:AB_11030828
- Product name
- Rabbit Polyclonal Granulin Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Specificity of human, mouse Granulin antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Frontotemporal dementia non-sense mutation of progranulin rescued by aminoglycosides.
Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.
Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice.
Kuang L, Hashimoto K, Huang EJ, Gentry MS, Zhu H
Human molecular genetics 2020 Mar 13;29(4):624-634
Human molecular genetics 2020 Mar 13;29(4):624-634
Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.
Nguyen AD, Nguyen TA, Zhang J, Devireddy S, Zhou P, Karydas AM, Xu X, Miller BL, Rigo F, Ferguson SM, Huang EJ, Walther TC, Farese RV Jr
Proceedings of the National Academy of Sciences of the United States of America 2018 Mar 20;115(12):E2849-E2858
Proceedings of the National Academy of Sciences of the United States of America 2018 Mar 20;115(12):E2849-E2858
Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice.
Elkabets M, Gifford AM, Scheel C, Nilsson B, Reinhardt F, Bray MA, Carpenter AE, Jirström K, Magnusson K, Ebert BL, Pontén F, Weinberg RA, McAllister SS
The Journal of clinical investigation 2011 Feb;121(2):784-99
The Journal of clinical investigation 2011 Feb;121(2):784-99
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Granulin Antibody [NBP1-87324] - Staining of human cerebral cortex shows moderate granular cytoplasmic positivity in neurons.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Granulin Antibody [NBP1-87324] - Staining of human kidney shows moderate granular cytoplasmic positivity in cells in tubules.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Granulin Antibody [NBP1-87324] - Staining of human placenta shows moderate to strong granular cytoplasmic positivity in trophoblastic cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Granulin Antibody [NBP1-87324] - Staining of human skeletal muscle shows very weak cytoplasmic positivity in striated muscle fibers.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: Granulin Antibody [NBP1-87324] - Staining in human placenta and skeletal muscle tissues . Corresponding GRN RNA-seq data are presented for the same tissues.