15597-1-AP

antibody from Proteintech Group

Targeting: MCM3

Provider product page for 15597-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [28]
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Validations
Western blot [1]

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Product number: 15597-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#15597-1-AP, RRID:AB_2141973
Product name: MCM3 antibody
Antibody type: Polyclonal
Description: KD/KO validated MCM3 antibody (Cat. #15597-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MCM3 protein structure - 15597-1-AP shown in red.

Submitted references Alu repeat-containing RNAs spatially organize actively transcribed genomic regions around nuclear speckles.

Liu S, Chen Z, Shen X, Gao J, Guo J, Rong Y, Li T, Zhou F, Si Y, Zhao H, Cheng T, Shi L, Yu J, Ma Y
Molecular cell 2026 May 7;86(9):1723-1741.e11

USP1 promotes hepatocellular carcinoma progression by modulating mitophagy via stabilizing MCM3 to regulate the Keap1-Nrf2 axis.

Chen Z, Sun C, Wang Y, Duan X, Ma H, Zhou X, Chen S, Peng P
iScience 2026 Mar 20;29(3):114927

Claudin18.2 promote gastric cancer proliferation by activating MCM2/5.

Zheng B, Fu M, Lou F, He Y, Zhao L, Huang X, Xie X, Tan W, Chen Q, Zhang W, Hong Y, Rong K, Lu Y, Zhan P, Tu J, Shi H, Hu T, Xiao L
Scientific reports 2026 Feb 23;16(1)

Overexpression of MCM3 as a prognostic biomarker correlated with cell proliferation, cell cycle and immune regulation in hepatocellular carcinoma.

Ju L, Wang H, Luo Y, Wang Y, Chen L, Han X, Lu R
Journal of Cancer 2025;16(5):1538-1554

Topoisomerase I Inhibition in ETV4-overexpressed Non-Small Cell Lung Cancer Promotes Replication and Transcription Mediated R-Loop Accumulation and DNA Damage.

Zhang J, Wang Y, Cao S, Xie SM, Liu B, Li Y, Hou Y, Meng X, Ruan M, Bu D, Kang J, Li R, Lou L, Wang J, Xing L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e09307

SETD3-mediated histidine methylation of MCM7 regulates DNA replication by facilitating chromatin loading of MCM.

Duan H, Wang S, Shu WJ, Tong Y, Long HZ, Li G, Du HN, Zhao MJ
Science China. Life sciences 2025 Mar;68(3):793-808

Histone Deacetylase Inhibitors Target DNA Replication Regulators and Replication Stress in Ewing Sarcoma Cells.

Koppenhafer SL, Geary EL, Thomas MV, Croushore EE, Zimmerman JAO, Gedminas JM, Quelle DE, Dodd RD, Gordon DJ
Cancer research communications 2025 Jun 1;5(6):1034-1048

Significant prognostic value of cell-cycle proteins in early-stage small cell carcinoma of cervix.

Xu Q, Zhou H, Wu J, Chang B, Gu Y, Li H, Cheng X
Scientific reports 2025 Jul 24;15(1):26860

BTNL9 exerts anti-cancer effects by inhibiting CDC20 to induce G2/M arrest in pancreatic cancer.

Xiao M, Luo ZY, Yu AR, Xu K, Zhou W
World journal of gastrointestinal oncology 2025 Jul 15;17(7):108274

The EZH2/MCM Complex/hTERT axis facilitates hepatocellular carcinoma progression by inhibiting cellular senescence.

Shen Z, Wang Y, Gao J, Gu W, Ren Z, Xu L, Qian R, Miao Q, Hu X, Wu Y, Liu W, Cai Y, Wan CC, Zhu Y, Sun L, Yan T
Mechanisms of ageing and development 2025 Apr;224:112040

YTHDF1 promotes gallbladder cancer progression via post-transcriptional regulation of the m6A/UHRF1 axis.

Chen J, Bai X, Zhang W, Yan Z, Liu Y, Zhou S, Wu X, He X, Yang A
Journal of cellular and molecular medicine 2024 May;28(9):e18328

RNF125‑mediated ubiquitination of MCM6 regulates the proliferation of human liver hepatocellular carcinoma cells.

Feng X, Song D, Liu X, Liang Y, Jiang P, Wu S, Liu F
Oncology letters 2024 Mar;27(3):105

Systematic analysis of expression and prognostic significance for MCM family in head and neck squamous cell carcinoma.

Sun E, Peng L, Liu Z, Yan Z, Chen M, Zheng J
Histology and histopathology 2024 Apr;39(4):471-482

FANCA facilitates G1/S cell cycle advancement, proliferation, migration and invasion in gastric cancer.

Wang W, Baral S, Liu B, Sun Q, Wang L, Ren J, Tang D, Wang D
Acta biochimica et biophysica Sinica 2024 Apr 29;56(7):973-985

Pyrroloquinoline quinone alleviates natural aging-related osteoporosis via a novel MCM3-Keap1-Nrf2 axis-mediated stress response and Fbn1 upregulation.

Li J, Zhang J, Xue Q, Liu B, Qin R, Li Y, Qiu Y, Wang R, Goltzman D, Miao D, Yang R
Aging cell 2023 Sep;22(9):e13912

Rac GTPase activating protein 1 promotes the glioma growth by regulating the expression of MCM3.

Jia B, Jiang Y, Huan Y, Han Y, Liu W, Liu X, Wang Y, He L, Cao Z, He X, Zhang K, Gu J, Guo Q, Fei Z
Translational oncology 2023 Nov;37:101756

ACTL6A deficiency induces apoptosis through impairing DNA replication and inhibiting the ATR-Chk1 signaling in glioblastoma cells.

Hu X, Pei D, Ci M, Zhang G, Li B, Wang J, Shen Y, Zhai X, Liang P, Cui H
Biochemical and biophysical research communications 2022 Apr 9;599:148-155

MCMBP promotes the assembly of the MCM2-7 hetero-hexamer to ensure robust DNA replication in human cells.

Saito Y, Santosa V, Ishiguro KI, Kanemaki MT
eLife 2022 Apr 19;11

The influence of phenolic environmental estrogen on the transcriptome of uterine leiomyoma cells: A whole transcriptome profiling-based analysis.

Li Z, Yin H, Shen Y, Ren M, Xu X
Ecotoxicology and environmental safety 2021 Mar 15;211:111945

Targeted Protein Depletion Using the Auxin-Inducible Degron 2 (AID2) System.

Saito Y, Kanemaki MT
Current protocols 2021 Aug;1(8):e219

ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer.

Taftaf R, Liu X, Singh S, Jia Y, Dashzeveg NK, Hoffmann AD, El-Shennawy L, Ramos EK, Adorno-Cruz V, Schuster EJ, Scholten D, Patel D, Zhang Y, Davis AA, Reduzzi C, Cao Y, D'Amico P, Shen Y, Cristofanilli M, Muller WA, Varadan V, Liu H
Nature communications 2021 Aug 11;12(1):4867

S-Adenosylmethionine Affects Cell Cycle Pathways and Suppresses Proliferation in Liver Cells.

Yan L, Liang X, Huang H, Zhang G, Liu T, Zhang J, Chen Z, Zhang Z, Chen Y
Journal of Cancer 2019;10(18):4368-4379

Expression and prognostic significance of MCM-3 and MCM-7 in salivary adenoid cystic carcinoma.

Wen QL, Zhu SM, Jiang LH, Xiang FY, Yin WJ, Qian YY, Huang YQ, Yin KX, Zhu X, Ge MH
International journal of clinical and experimental pathology 2018;11(11):5359-5369

Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.

Song H, Guo T, Zhao Z, Wei Y, Luo H, Weng W, Zhang R, Zhong M, Chen C, Su J, Shen W
Biomaterials 2018 Sep;178:23-35

MCM7 expression is correlated with histological subtypes of lung adenocarcinoma and predictive of poor prognosis.

Wang H, Zhou C, Su B, Teng G, Zheng Y, Zhou X, Guo L, Xu F, Wang X
International journal of clinical and experimental pathology 2017;10(12):11747-11753

Lamin B2 binding to minichromosome maintenance complex component 7 promotes non-small cell lung carcinogenesis.

Ma Y, Fei L, Zhang M, Zhang W, Liu X, Wang C, Luo Y, Zhang H, Han Y
Oncotarget 2017 Dec 1;8(62):104813-104830

Minichromosome maintenance complex component 7 has an important role in the invasion of papillary urothelial neoplasia.

Guan B, Wang X, Yang J, Zhou C, Meng Y
Oncology letters 2015 Aug;10(2):946-950

Elevated transcriptional co-activator p102 mediates angiotensin II type 1 receptor up-regulation and extracellular matrix overproduction in the high glucose-treated rat glomerular mesangial cells and isolated glomeruli.

Wang Z, Ni J, Shao D, Liu J, Shen Y, Zhou L, Huang Y, Yu C, Wang J, Xue H, Lu L
European journal of pharmacology 2013 Feb 28;702(1-3):208-17

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The MCM3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MCM3. This antibody recognizes human,mouse,rat antigen. The MCM3 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 15597-1-AP.pdf

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