orb534365

antibody from Biorbyt

Targeting: BCL6 BCL5, BCL6A, LAZ3, ZBTB27, ZNF51

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

orb534365

Provider

Biorbyt

Product name

Bcl6 Antibody

Antibody type

Recombinant

Description

Bcl6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. [UniProt]

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antibody clone number

ARBC6-2R

Vial size

20 ug

Storage

Store the recombinant Bcl6 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).