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- Antibody Data
- Antigen structure
- References [85]
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- Product number
- NB100-147 - Provider product page
- Provider
- Novus Biologicals
- Product name
- RAD50 Antibody (13B3)
- Antibody type
- Monoclonal
- Antigen
- Fusion protein containing the complete coding region (amino acids 1-425) of human Rad50, expressed in E. coli.
- Host
- Mouse
- Isotype
- IgG
- Concentration
- 1 mg/ml
Submitted references Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin.
Cancer initiating-cells are enriched in the CA9 positive fraction of primary cervix cancer xenografts.
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.
Listeria monocytogenes dampens the DNA damage response.
FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance.
Novel regulatory role for Kaposi's sarcoma-associated herpesvirus-encoded vFLIP in chemosensitization to bleomycin.
Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly.
Human T-lymphotropic type 1 virus p30 inhibits homologous recombination and favors unfaithful DNA repair.
Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906.
Bocavirus infection induces a DNA damage response that facilitates viral DNA replication and mediates cell death.
CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors.
SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype.
Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks.
Telomerase-dependent oncolytic adenovirus sensitizes human cancer cells to ionizing radiation via inhibition of DNA repair machinery.
Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents.
Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response.
53BP1 promotes ATM activity through direct interactions with the MRN complex.
Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex.
Analysis of DNA double-strand break response and chromatin structure in mitosis using laser microirradiation.
Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes.
Adeno-associated virus and adenovirus coinfection induces a cellular DNA damage and repair response via redundant phosphatidylinositol 3-like kinase pathways.
Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.
Temporal regulation of the Mre11-Rad50-Nbs1 complex during adenovirus infection.
MRE11 complex links RECQ5 helicase to sites of DNA damage.
Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection.
Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase.
Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation.
Characterization of mre11 loss following HSV-1 infection.
Processing of recombinant AAV genomes occurs in specific nuclear structures that overlap with foci of DNA-damage-response proteins.
Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.
Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres.
ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain.
Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors.
A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends.
RINT-1 serves as a tumor suppressor and maintains Golgi dynamics and centrosome integrity for cell survival.
Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone.
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication.
Inhibition of hsp90 compromises the DNA damage response to radiation.
Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
Microsatellite instability and mutation analysis of candidate genes in urothelial cell carcinomas of upper urinary tract.
Evaluation of RAD50 in familial breast cancer predisposition.
An hGCN5/TRRAP histone acetyltransferase complex co-activates BRCA1 transactivation function through histone modification.
Rapid activation of ATR by ionizing radiation requires ATM and Mre11.
The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1.
Impaired nonhomologous end-joining in mismatch repair-deficient colon carcinomas.
Adenovirus exploits the cellular aggresome response to accelerate inactivation of the MRN complex.
Analysis of ionizing radiation-induced foci of DNA damage repair proteins.
Evidence for the direct binding of phosphorylated p53 to sites of DNA breaks in vivo.
Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells.
DNA repair proteins affect the lifecycle of herpes simplex virus 1.
Telomerase-independent telomere length maintenance in the absence of alternative lengthening of telomeres-associated promyelocytic leukemia bodies.
Expression of ATM, p53, and the MRE11-Rad50-NBS1 complex in myoepithelial cells from benign and malignant proliferations of the breast.
Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage response.
Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage response.
SV40 T antigen interacts with Nbs1 to disrupt DNA replication control.
The human Rap1 protein complex and modulation of telomere length.
Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability.
Slow progression of ataxia-telangiectasia with double missense and in frame splice mutations.
Altered expression of DNA double-strand break detection and repair proteins in breast carcinomas.
Altered expression of DNA double-strand break detection and repair proteins in breast carcinomas.
NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors.
Requirement of the MRN complex for ATM activation by DNA damage.
Distinct roles of the Adenovirus E4 ORF3 protein in viral DNA replication and inhibition of genome concatenation.
Distinct roles of the Adenovirus E4 ORF3 protein in viral DNA replication and inhibition of genome concatenation.
Campylobacter jejuni cytolethal distending toxin promotes DNA repair responses in normal human cells.
Campylobacter jejuni cytolethal distending toxin promotes DNA repair responses in normal human cells.
Regulation of RelA (p65) function by the large subunit of replication factor C.
Regulation of RelA (p65) function by the large subunit of replication factor C.
MDC1 is a mediator of the mammalian DNA damage checkpoint.
The Mre11 complex is required for ATM activation and the G2/M checkpoint.
DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein.
DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein.
Specific recruitment of human cohesin to laser-induced DNA damage.
PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damage.
Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex.
hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage.
hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage.
Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest.
The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity.
Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome.
Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome.
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Sivalingam VN, Latif A, Kitson S, McVey R, Finegan KG, Marshall K, Lisanti MP, Sotgia F, Stratford IJ, Crosbie EJ
British journal of cancer 2020 Jan;122(1):62-71
British journal of cancer 2020 Jan;122(1):62-71
Cancer initiating-cells are enriched in the CA9 positive fraction of primary cervix cancer xenografts.
Marie-Egyptienne DT, Chaudary N, Kalliomäki T, Hedley DW, Hill RP
Oncotarget 2017 Jan 3;8(1):1392-1404
Oncotarget 2017 Jan 3;8(1):1392-1404
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.
Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins DM, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I
Nature communications 2016 May 18;7:11635
Nature communications 2016 May 18;7:11635
Listeria monocytogenes dampens the DNA damage response.
Samba-Louaka A, Pereira JM, Nahori MA, Villiers V, Deriano L, Hamon MA, Cossart P
PLoS pathogens 2014 Oct;10(10):e1004470
PLoS pathogens 2014 Oct;10(10):e1004470
FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance.
Khongkow P, Karunarathna U, Khongkow M, Gong C, Gomes AR, Yagüe E, Monteiro LJ, Kongsema M, Zona S, Man EP, Tsang JW, Coombes RC, Wu KJ, Khoo US, Medema RH, Freire R, Lam EW
Oncogene 2014 Aug 7;33(32):4144-55
Oncogene 2014 Aug 7;33(32):4144-55
Novel regulatory role for Kaposi's sarcoma-associated herpesvirus-encoded vFLIP in chemosensitization to bleomycin.
Masuda Y, Noguchi K, Segawa H, Tanaka N, Katayama K, Mitsuhashi J, Sugimoto Y
Biochemical and biophysical research communications 2011 Nov 18;415(2):305-12
Biochemical and biophysical research communications 2011 Nov 18;415(2):305-12
Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly.
Matsumoto Y, Miyamoto T, Sakamoto H, Izumi H, Nakazawa Y, Ogi T, Tahara H, Oku S, Hiramoto A, Shiiki T, Fujisawa Y, Ohashi H, Sakemi Y, Matsuura S
DNA repair 2011 Mar 7;10(3):314-21
DNA repair 2011 Mar 7;10(3):314-21
Human T-lymphotropic type 1 virus p30 inhibits homologous recombination and favors unfaithful DNA repair.
Baydoun HH, Pancewicz J, Nicot C
Blood 2011 Jun 2;117(22):5897-906
Blood 2011 Jun 2;117(22):5897-906
Ataxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906.
Soares DG, Battistella A, Rocca CJ, Matuo R, Henriques JA, Larsen AK, Escargueil AE
The Biochemical journal 2011 Jul 1;437(1):63-73
The Biochemical journal 2011 Jul 1;437(1):63-73
Bocavirus infection induces a DNA damage response that facilitates viral DNA replication and mediates cell death.
Luo Y, Chen AY, Qiu J
Journal of virology 2011 Jan;85(1):133-45
Journal of virology 2011 Jan;85(1):133-45
CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors.
Anderson VE, Walton MI, Eve PD, Boxall KJ, Antoni L, Caldwell JJ, Aherne W, Pearl LH, Oliver AW, Collins I, Garrett MD
Cancer research 2011 Jan 15;71(2):463-72
Cancer research 2011 Jan 15;71(2):463-72
SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype.
Stoepker C, Hain K, Schuster B, Hilhorst-Hofstee Y, Rooimans MA, Steltenpool J, Oostra AB, Eirich K, Korthof ET, Nieuwint AW, Jaspers NG, Bettecken T, Joenje H, Schindler D, Rouse J, de Winter JP
Nature genetics 2011 Feb;43(2):138-41
Nature genetics 2011 Feb;43(2):138-41
Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks.
Cheng Q, Barboule N, Frit P, Gomez D, Bombarde O, Couderc B, Ren GS, Salles B, Calsou P
Nucleic acids research 2011 Dec;39(22):9605-19
Nucleic acids research 2011 Dec;39(22):9605-19
Telomerase-dependent oncolytic adenovirus sensitizes human cancer cells to ionizing radiation via inhibition of DNA repair machinery.
Kuroda S, Fujiwara T, Shirakawa Y, Yamasaki Y, Yano S, Uno F, Tazawa H, Hashimoto Y, Watanabe Y, Noma K, Urata Y, Kagawa S, Fujiwara T
Cancer research 2010 Nov 15;70(22):9339-48
Cancer research 2010 Nov 15;70(22):9339-48
Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents.
Palagyi A, Neveling K, Plinninger U, Ziesch A, Targosz BS, Denk GU, Ochs S, Rizzani A, Meier D, Thasler WE, Hanenberg H, De Toni EN, Bassermann F, Schäfer C, Göke B, Schindler D, Gallmeier E
Molecular cancer 2010 May 28;9:127
Molecular cancer 2010 May 28;9:127
Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response.
Cha H, Lowe JM, Li H, Lee JS, Belova GI, Bulavin DV, Fornace AJ Jr
Cancer research 2010 May 15;70(10):4112-22
Cancer research 2010 May 15;70(10):4112-22
53BP1 promotes ATM activity through direct interactions with the MRN complex.
Lee JH, Goodarzi AA, Jeggo PA, Paull TT
The EMBO journal 2010 Feb 3;29(3):574-85
The EMBO journal 2010 Feb 3;29(3):574-85
Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex.
Balasubramanian N, Bai P, Buchek G, Korza G, Weller SK
Journal of virology 2010 Dec;84(24):12504-14
Journal of virology 2010 Dec;84(24):12504-14
Analysis of DNA double-strand break response and chromatin structure in mitosis using laser microirradiation.
Gomez-Godinez V, Wu T, Sherman AJ, Lee CS, Liaw LH, Zhongsheng Y, Yokomori K, Berns MW
Nucleic acids research 2010 Dec;38(22):e202
Nucleic acids research 2010 Dec;38(22):e202
Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes.
Machida K, McNamara G, Cheng KT, Huang J, Wang CH, Comai L, Ou JH, Lai MM
Journal of immunology (Baltimore, Md. : 1950) 2010 Dec 1;185(11):6985-98
Journal of immunology (Baltimore, Md. : 1950) 2010 Dec 1;185(11):6985-98
Adeno-associated virus and adenovirus coinfection induces a cellular DNA damage and repair response via redundant phosphatidylinositol 3-like kinase pathways.
Collaco RF, Bevington JM, Bhrigu V, Kalman-Maltese V, Trempe JP
Virology 2009 Sep 15;392(1):24-33
Virology 2009 Sep 15;392(1):24-33
Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder.
Waltes R, Kalb R, Gatei M, Kijas AW, Stumm M, Sobeck A, Wieland B, Varon R, Lerenthal Y, Lavin MF, Schindler D, Dörk T
American journal of human genetics 2009 May;84(5):605-16
American journal of human genetics 2009 May;84(5):605-16
Temporal regulation of the Mre11-Rad50-Nbs1 complex during adenovirus infection.
Karen KA, Hoey PJ, Young CS, Hearing P
Journal of virology 2009 May;83(9):4565-73
Journal of virology 2009 May;83(9):4565-73
MRE11 complex links RECQ5 helicase to sites of DNA damage.
Zheng L, Kanagaraj R, Mihaljevic B, Schwendener S, Sartori AA, Gerrits B, Shevelev I, Janscak P
Nucleic acids research 2009 May;37(8):2645-57
Nucleic acids research 2009 May;37(8):2645-57
Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection.
Carson CT, Orazio NI, Lee DV, Suh J, Bekker-Jensen S, Araujo FD, Lakdawala SS, Lilley CE, Bartek J, Lukas J, Weitzman MD
The EMBO journal 2009 Mar 18;28(6):652-62
The EMBO journal 2009 Mar 18;28(6):652-62
Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase.
Schwartz RA, Carson CT, Schuberth C, Weitzman MD
Journal of virology 2009 Jun;83(12):6269-78
Journal of virology 2009 Jun;83(12):6269-78
Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation.
Lakdawala SS, Schwartz RA, Ferenchak K, Carson CT, McSharry BP, Wilkinson GW, Weitzman MD
Journal of virology 2008 Sep;82(17):8362-72
Journal of virology 2008 Sep;82(17):8362-72
Characterization of mre11 loss following HSV-1 infection.
Gregory DA, Bachenheimer SL
Virology 2008 Mar 30;373(1):124-36
Virology 2008 Mar 30;373(1):124-36
Processing of recombinant AAV genomes occurs in specific nuclear structures that overlap with foci of DNA-damage-response proteins.
Cervelli T, Palacios JA, Zentilin L, Mano M, Schwartz RA, Weitzman MD, Giacca M
Journal of cell science 2008 Feb 1;121(Pt 3):349-57
Journal of cell science 2008 Feb 1;121(Pt 3):349-57
Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene.
Bartkova J, Tommiska J, Oplustilova L, Aaltonen K, Tamminen A, Heikkinen T, Mistrik M, Aittomäki K, Blomqvist C, Heikkilä P, Lukas J, Nevanlinna H, Bartek J
Molecular oncology 2008 Dec;2(4):296-316
Molecular oncology 2008 Dec;2(4):296-316
Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres.
Zhong ZH, Jiang WQ, Cesare AJ, Neumann AA, Wadhwa R, Reddel RR
The Journal of biological chemistry 2007 Oct 5;282(40):29314-22
The Journal of biological chemistry 2007 Oct 5;282(40):29314-22
ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain.
Gorodetsky E, Calkins S, Ahn J, Brooks PJ
DNA repair 2007 Nov;6(11):1698-707
DNA repair 2007 Nov;6(11):1698-707
Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors.
You KT, Li LS, Kim NG, Kang HJ, Koh KH, Chwae YJ, Kim KM, Kim YK, Park SM, Jang SK, Kim H
PLoS biology 2007 May;5(5):e109
PLoS biology 2007 May;5(5):e109
A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends.
Bae NS, Baumann P
Molecular cell 2007 May 11;26(3):323-34
Molecular cell 2007 May 11;26(3):323-34
RINT-1 serves as a tumor suppressor and maintains Golgi dynamics and centrosome integrity for cell survival.
Lin X, Liu CC, Gao Q, Zhang X, Wu G, Lee WH
Molecular and cellular biology 2007 Jul;27(13):4905-16
Molecular and cellular biology 2007 Jul;27(13):4905-16
Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone.
Bentle MS, Reinicke KE, Dong Y, Bey EA, Boothman DA
Cancer research 2007 Jul 15;67(14):6936-45
Cancer research 2007 Jul 15;67(14):6936-45
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K
The Journal of biological chemistry 2007 Jul 13;282(28):20395-406
The Journal of biological chemistry 2007 Jul 13;282(28):20395-406
The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication.
Schwartz RA, Palacios JA, Cassell GD, Adam S, Giacca M, Weitzman MD
Journal of virology 2007 Dec;81(23):12936-45
Journal of virology 2007 Dec;81(23):12936-45
Inhibition of hsp90 compromises the DNA damage response to radiation.
Dote H, Burgan WE, Camphausen K, Tofilon PJ
Cancer research 2006 Sep 15;66(18):9211-20
Cancer research 2006 Sep 15;66(18):9211-20
Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y
The Journal of biological chemistry 2006 Oct 13;281(41):30814-23
The Journal of biological chemistry 2006 Oct 13;281(41):30814-23
Microsatellite instability and mutation analysis of candidate genes in urothelial cell carcinomas of upper urinary tract.
Mongiat-Artus P, Miquel C, Van der Aa M, Buhard O, Hamelin R, Soliman H, Bangma C, Janin A, Teillac P, van der Kwast T, Praz F
Oncogene 2006 Mar 30;25(14):2113-8
Oncogene 2006 Mar 30;25(14):2113-8
Evaluation of RAD50 in familial breast cancer predisposition.
Tommiska J, Seal S, Renwick A, Barfoot R, Baskcomb L, Jayatilake H, Bartkova J, Tallila J, Kaare M, Tamminen A, Heikkilä P, Evans DG, Eccles D, Aittomäki K, Blomqvist C, Bartek J, Stratton MR, Nevanlinna H, Rahman N
International journal of cancer 2006 Jun 1;118(11):2911-6
International journal of cancer 2006 Jun 1;118(11):2911-6
An hGCN5/TRRAP histone acetyltransferase complex co-activates BRCA1 transactivation function through histone modification.
Oishi H, Kitagawa H, Wada O, Takezawa S, Tora L, Kouzu-Fujita M, Takada I, Yano T, Yanagisawa J, Kato S
The Journal of biological chemistry 2006 Jan 6;281(1):20-6
The Journal of biological chemistry 2006 Jan 6;281(1):20-6
Rapid activation of ATR by ionizing radiation requires ATM and Mre11.
Myers JS, Cortez D
The Journal of biological chemistry 2006 Apr 7;281(14):9346-50
The Journal of biological chemistry 2006 Apr 7;281(14):9346-50
The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1.
Kong LJ, Meloni AR, Nevins JR
Molecular cell 2006 Apr 7;22(1):63-71
Molecular cell 2006 Apr 7;22(1):63-71
Impaired nonhomologous end-joining in mismatch repair-deficient colon carcinomas.
Koh KH, Kang HJ, Li LS, Kim NG, You KT, Yang E, Kim H, Kim HJ, Yun CO, Kim KS, Kim H
Laboratory investigation; a journal of technical methods and pathology 2005 Sep;85(9):1130-8
Laboratory investigation; a journal of technical methods and pathology 2005 Sep;85(9):1130-8
Adenovirus exploits the cellular aggresome response to accelerate inactivation of the MRN complex.
Liu Y, Shevchenko A, Shevchenko A, Berk AJ
Journal of virology 2005 Nov;79(22):14004-16
Journal of virology 2005 Nov;79(22):14004-16
Analysis of ionizing radiation-induced foci of DNA damage repair proteins.
van Veelen LR, Cervelli T, van de Rakt MW, Theil AF, Essers J, Kanaar R
Mutation research 2005 Jul 1;574(1-2):22-33
Mutation research 2005 Jul 1;574(1-2):22-33
Evidence for the direct binding of phosphorylated p53 to sites of DNA breaks in vivo.
Al Rashid ST, Dellaire G, Cuddihy A, Jalali F, Vaid M, Coackley C, Folkard M, Xu Y, Chen BP, Chen DJ, Lilge L, Prise KM, Bazett Jones DP, Bristow RG
Cancer research 2005 Dec 1;65(23):10810-21
Cancer research 2005 Dec 1;65(23):10810-21
Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells.
Kim JS, Krasieva TB, Kurumizaka H, Chen DJ, Taylor AM, Yokomori K
The Journal of cell biology 2005 Aug 1;170(3):341-7
The Journal of cell biology 2005 Aug 1;170(3):341-7
DNA repair proteins affect the lifecycle of herpes simplex virus 1.
Lilley CE, Carson CT, Muotri AR, Gage FH, Weitzman MD
Proceedings of the National Academy of Sciences of the United States of America 2005 Apr 19;102(16):5844-9
Proceedings of the National Academy of Sciences of the United States of America 2005 Apr 19;102(16):5844-9
Telomerase-independent telomere length maintenance in the absence of alternative lengthening of telomeres-associated promyelocytic leukemia bodies.
Fasching CL, Bower K, Reddel RR
Cancer research 2005 Apr 1;65(7):2722-9
Cancer research 2005 Apr 1;65(7):2722-9
Expression of ATM, p53, and the MRE11-Rad50-NBS1 complex in myoepithelial cells from benign and malignant proliferations of the breast.
Angèle S, Jones C, Reis Filho JS, Fulford LG, Treilleux I, Lakhani SR, Hall J
Journal of clinical pathology 2004 Nov;57(11):1179-84
Journal of clinical pathology 2004 Nov;57(11):1179-84
Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage response.
Wilkinson DE, Weller SK
Journal of virology 2004 May;78(9):4783-96
Journal of virology 2004 May;78(9):4783-96
Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage response.
Wilkinson DE, Weller SK
Journal of virology 2004 May;78(9):4783-96
Journal of virology 2004 May;78(9):4783-96
SV40 T antigen interacts with Nbs1 to disrupt DNA replication control.
Wu X, Avni D, Chiba T, Yan F, Zhao Q, Lin Y, Heng H, Livingston D
Genes & development 2004 Jun 1;18(11):1305-16
Genes & development 2004 Jun 1;18(11):1305-16
The human Rap1 protein complex and modulation of telomere length.
O'Connor MS, Safari A, Liu D, Qin J, Songyang Z
The Journal of biological chemistry 2004 Jul 2;279(27):28585-91
The Journal of biological chemistry 2004 Jul 2;279(27):28585-91
Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability.
Giannini G, Rinaldi C, Ristori E, Ambrosini MI, Cerignoli F, Viel A, Bidoli E, Berni S, D'Amati G, Scambia G, Frati L, Screpanti I, Gulino A
Oncogene 2004 Apr 8;23(15):2640-7
Oncogene 2004 Apr 8;23(15):2640-7
Slow progression of ataxia-telangiectasia with double missense and in frame splice mutations.
Dörk T, Bendix-Waltes R, Wegner RD, Stumm M
American journal of medical genetics. Part A 2004 Apr 30;126A(3):272-7
American journal of medical genetics. Part A 2004 Apr 30;126A(3):272-7
Altered expression of DNA double-strand break detection and repair proteins in breast carcinomas.
Angèle S, Treilleux I, Brémond A, Tanière P, Hall J
Histopathology 2003 Oct;43(4):347-53
Histopathology 2003 Oct;43(4):347-53
Altered expression of DNA double-strand break detection and repair proteins in breast carcinomas.
Angèle S, Treilleux I, Brémond A, Tanière P, Hall J
Histopathology 2003 Oct;43(4):347-53
Histopathology 2003 Oct;43(4):347-53
NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors.
Xu X, Stern DF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003 Oct;17(13):1842-8
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003 Oct;17(13):1842-8
Requirement of the MRN complex for ATM activation by DNA damage.
Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittelman L, Shiloh Y
The EMBO journal 2003 Oct 15;22(20):5612-21
The EMBO journal 2003 Oct 15;22(20):5612-21
Distinct roles of the Adenovirus E4 ORF3 protein in viral DNA replication and inhibition of genome concatenation.
Evans JD, Hearing P
Journal of virology 2003 May;77(9):5295-304
Journal of virology 2003 May;77(9):5295-304
Distinct roles of the Adenovirus E4 ORF3 protein in viral DNA replication and inhibition of genome concatenation.
Evans JD, Hearing P
Journal of virology 2003 May;77(9):5295-304
Journal of virology 2003 May;77(9):5295-304
Campylobacter jejuni cytolethal distending toxin promotes DNA repair responses in normal human cells.
Hassane DC, Lee RB, Pickett CL
Infection and immunity 2003 Jan;71(1):541-5
Infection and immunity 2003 Jan;71(1):541-5
Campylobacter jejuni cytolethal distending toxin promotes DNA repair responses in normal human cells.
Hassane DC, Lee RB, Pickett CL
Infection and immunity 2003 Jan;71(1):541-5
Infection and immunity 2003 Jan;71(1):541-5
Regulation of RelA (p65) function by the large subunit of replication factor C.
Anderson LA, Perkins ND
Molecular and cellular biology 2003 Jan;23(2):721-32
Molecular and cellular biology 2003 Jan;23(2):721-32
Regulation of RelA (p65) function by the large subunit of replication factor C.
Anderson LA, Perkins ND
Molecular and cellular biology 2003 Jan;23(2):721-32
Molecular and cellular biology 2003 Jan;23(2):721-32
MDC1 is a mediator of the mammalian DNA damage checkpoint.
Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ
Nature 2003 Feb 27;421(6926):961-6
Nature 2003 Feb 27;421(6926):961-6
The Mre11 complex is required for ATM activation and the G2/M checkpoint.
Carson CT, Schwartz RA, Stracker TH, Lilley CE, Lee DV, Weitzman MD
The EMBO journal 2003 Dec 15;22(24):6610-20
The EMBO journal 2003 Dec 15;22(24):6610-20
DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein.
Pichierri P, Averbeck D, Rosselli F
Human molecular genetics 2002 Oct 1;11(21):2531-46
Human molecular genetics 2002 Oct 1;11(21):2531-46
DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein.
Pichierri P, Averbeck D, Rosselli F
Human molecular genetics 2002 Oct 1;11(21):2531-46
Human molecular genetics 2002 Oct 1;11(21):2531-46
Specific recruitment of human cohesin to laser-induced DNA damage.
Kim JS, Krasieva TB, LaMorte V, Taylor AM, Yokomori K
The Journal of biological chemistry 2002 Nov 22;277(47):45149-53
The Journal of biological chemistry 2002 Nov 22;277(47):45149-53
PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damage.
Carbone R, Pearson M, Minucci S, Pelicci PG
Oncogene 2002 Mar 7;21(11):1633-40
Oncogene 2002 Mar 7;21(11):1633-40
Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex.
Stracker TH, Carson CT, Weitzman MD
Nature 2002 Jul 18;418(6895):348-52
Nature 2002 Jul 18;418(6895):348-52
hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage.
Richie CT, Peterson C, Lu T, Hittelman WN, Carpenter PB, Legerski RJ
Molecular and cellular biology 2002 Dec;22(24):8635-47
Molecular and cellular biology 2002 Dec;22(24):8635-47
hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage.
Richie CT, Peterson C, Lu T, Hittelman WN, Carpenter PB, Legerski RJ
Molecular and cellular biology 2002 Dec;22(24):8635-47
Molecular and cellular biology 2002 Dec;22(24):8635-47
Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest.
Franchitto A, Pichierri P
The Journal of cell biology 2002 Apr 1;157(1):19-30
The Journal of cell biology 2002 Apr 1;157(1):19-30
The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity.
Tauchi H, Kobayashi J, Morishima K, Matsuura S, Nakamura A, Shiraishi T, Ito E, Masnada D, Delia D, Komatsu K
The Journal of biological chemistry 2001 Jan 5;276(1):12-5
The Journal of biological chemistry 2001 Jan 5;276(1):12-5
Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome.
Harfst E, Cooper S, Neubauer S, Distel L, Grawunder U
Molecular immunology 2000 Oct;37(15):915-29
Molecular immunology 2000 Oct;37(15):915-29
Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome.
Harfst E, Cooper S, Neubauer S, Distel L, Grawunder U
Molecular immunology 2000 Oct;37(15):915-29
Molecular immunology 2000 Oct;37(15):915-29
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.
Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM
Current biology : CB 2000 Jul 27-Aug 10;10(15):886-95
Current biology : CB 2000 Jul 27-Aug 10;10(15):886-95
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.
Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM
Current biology : CB 2000 Jul 27-Aug 10;10(15):886-95
Current biology : CB 2000 Jul 27-Aug 10;10(15):886-95
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J
Genes & development 2000 Apr 15;14(8):927-39
Genes & development 2000 Apr 15;14(8):927-39
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