Antibody data

Product number
Ab124364 - Provider product page
Provider
Aladdin Scientific
Product name
Recombinant Rad50 Antibody
Antibody type
Recombinant
Description
Rabbit anti Human Rad50 Antibody, Recombinant, could be used for WB, IHC and so on.Application:á WB: 1/500-1/1000á IHC: 1/50-1/100Protein FunctionComponent of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
AA 1-425
Vial size
100_l,10_l,1ml,50_l
Concentration
0,6 mg/ml
Storage
Store at 4¡C short term (1-2 weeks). Store at -20¡C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
RAD50 protein structure - Ab124364 shown in red.