Tissue expression
Cell line expression
Protein structure

NISCH

Nischarin
I-1, IRAS, KIAA0975 
This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013]
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105 antibodies from 24 providers.

Antibody properties

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
1 antibody
Invitrogen Antibodies
7 antibodies
antibodies-online
28 antibodies
FineTest Biotech
1 antibody
NovoPro Bioscience Inc.
1 antibody
Novus Biologicals
4 antibodies
Enzo Life Sciences
4 antibodies
Cusabio Biotech Co., Ltd
2 antibodies
Abgent
1 antibody
Abnova Corporation
2 antibodies
St John's Laboratory
2 antibodies
Atlas Antibodies
1 antibody
Creative Biolabs
8 antibodies
Abbexa
4 antibodies
Affinity Biosciences
1 antibody
Bethyl Laboratories
1 antibody
Cell Signaling Technology, Inc
1 antibody
Creative Diagnostics
2 antibodies
MyBioSource
1 antibody
RayBiotech, Inc.
1 antibody
Leading Biology
2 antibodies
MilliporeSigma / Merck KGaA
2 antibodies
ProSci
1 antibody