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Learn14573-1-AP
antibody from Proteintech Group
Targeting: PPM1K
BDP, DKFZp761G058, hPTMP, PP2Ckappa, PP2Cm
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [10]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 14573-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14573-1-AP, RRID:AB_2252953
- Product name
- PPM1K antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PPM1K antibody (Cat. #14573-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Branched-chain α-keto acids impair glucose-stimulated insulin secretion in pancreatic β-cells under diabetes by reactivating the LDHA-lactate axis.
Dietary BCAA supplementation counteracts the beneficial effects of long-term aerobic exercise against obesity and associated metabolic disorders by suppressing FGF21 expression.
BCAA exaggerated acute and chronic ischemic heart disease through promotion of NLRP3 via Sirt1.
Opposing effects of systemic and pancreas-specific inhibition of BCKDK on pancreatic carcinogenesis.
KIC (ketoisocaproic acid) and leucine have divergent effects on tissue insulin signaling but not on whole-body insulin sensitivity in rats.
Maintenance of the branched-chain amino acid transporter LAT1 counteracts myotube atrophy following chemotherapy.
Downregulation of extramitochondrial BCKDH and its uncoupling from AMP deaminase in type 2 diabetic OLETF rat hearts.
Pyridostigmine Protects Against Diabetic Cardiomyopathy by Regulating Vagal Activity, Gut Microbiota, and Branched-Chain Amino Acid Catabolism in Diabetic Mice.
Elevated branched-chain α-keto acids exacerbate macrophage oxidative stress and chronic inflammatory damage in type 2 diabetes mellitus.
Glucose promotes cell growth by suppressing branched-chain amino acid degradation.
Lin H, Ho MYM, Wang B, Mansoori S, Yang Y, Wang W, So PK, Xu A, Yang S, Chang J, Man AMH, Piao H, Gao C, Siu PMF, Li X, Cheng KKY
Nature communications 2026 Mar 2;17(1)
Nature communications 2026 Mar 2;17(1)
Dietary BCAA supplementation counteracts the beneficial effects of long-term aerobic exercise against obesity and associated metabolic disorders by suppressing FGF21 expression.
Zhang J, Zhang X, Li P, Liu Y, Zhang C, Lu M, Gao L, Song Z, Sun H, Qiu J
Diabetes, obesity & metabolism 2025 Nov;27(11):6449-6459
Diabetes, obesity & metabolism 2025 Nov;27(11):6449-6459
BCAA exaggerated acute and chronic ischemic heart disease through promotion of NLRP3 via Sirt1.
Peng Y, Duan Y, Wang D, Liu J, Zhao G, Ji Z, Zhang J, Wei B
Biochemical pharmacology 2025 Nov;241:117150
Biochemical pharmacology 2025 Nov;241:117150
Opposing effects of systemic and pancreas-specific inhibition of BCKDK on pancreatic carcinogenesis.
Noji MC, Demetriadou C, Landis M, Pennise J, Pinheiro LV, Jaccard A, Chatoff A, Drummond J, Guo K, Azor R, Robertson MR, Kawakami R, Marcinkiewicz MM, Tobias JW, Snyder NW, Feldser D, Arany Z, Wellen KE
bioRxiv : the preprint server for biology 2025 Jun 15;
bioRxiv : the preprint server for biology 2025 Jun 15;
KIC (ketoisocaproic acid) and leucine have divergent effects on tissue insulin signaling but not on whole-body insulin sensitivity in rats.
Mann G, Mora S, Adegoke OAJ
PloS one 2024;19(8):e0309324
PloS one 2024;19(8):e0309324
Maintenance of the branched-chain amino acid transporter LAT1 counteracts myotube atrophy following chemotherapy.
Mora S, Adegoke OAJ
American journal of physiology. Cell physiology 2024 Mar 1;326(3):C866-C879
American journal of physiology. Cell physiology 2024 Mar 1;326(3):C866-C879
Downregulation of extramitochondrial BCKDH and its uncoupling from AMP deaminase in type 2 diabetic OLETF rat hearts.
Ogawa T, Kouzu H, Osanami A, Tatekoshi Y, Sato T, Kuno A, Fujita Y, Ino S, Shimizu M, Toda Y, Ohwada W, Yano T, Tanno M, Miki T, Miura T
Physiological reports 2023 Feb;11(4):e15608
Physiological reports 2023 Feb;11(4):e15608
Pyridostigmine Protects Against Diabetic Cardiomyopathy by Regulating Vagal Activity, Gut Microbiota, and Branched-Chain Amino Acid Catabolism in Diabetic Mice.
Yang Y, Zhao M, He X, Wu Q, Li DL, Zang WJ
Frontiers in pharmacology 2021;12:647481
Frontiers in pharmacology 2021;12:647481
Elevated branched-chain α-keto acids exacerbate macrophage oxidative stress and chronic inflammatory damage in type 2 diabetes mellitus.
Liu S, Li L, Lou P, Zhao M, Wang Y, Tang M, Gong M, Liao G, Yuan Y, Li L, Zhang J, Chen Y, Cheng J, Lu Y, Liu J
Free radical biology & medicine 2021 Nov 1;175:141-154
Free radical biology & medicine 2021 Nov 1;175:141-154
Glucose promotes cell growth by suppressing branched-chain amino acid degradation.
Shao D, Villet O, Zhang Z, Choi SW, Yan J, Ritterhoff J, Gu H, Djukovic D, Christodoulou D, Kolwicz SC Jr, Raftery D, Tian R
Nature communications 2018 Jul 26;9(1):2935
Nature communications 2018 Jul 26;9(1):2935
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 14573-1-AP(PPM1K antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human gliomas using 14573-1-AP(PPM1K antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PPM1K antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PPM1K. This antibody recognizes human, mouse, rat antigen. The PPM1K antibody has been validated for the following applications: ELISA, WB, IHC analysis.
