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- Antibody Data
- Antigen structure
- References [8]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 66159-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- NAPRT1 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated NAPRT1 antibody (Cat. #66159-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 5D8H10
- Vial size
- 20ul, 150ul
Submitted references Computer assisted discovery of novel nicotinamide phosphoribosyltransferase agonists to combat muscle atrophy.
NAD(+) Metabolism Reprogramming Drives SIRT1-Dependent Deacetylation Inducing PD-L1 Nuclear Localization in Cervical Cancer.
NAPRT Silencing in FH-Deficient Renal Cell Carcinoma Confers Therapeutic Vulnerabilities via NAD+ Depletion.
Discovery of potent and novel dual NAMPT/BRD4 inhibitors for efficient treatment of hepatocellular carcinoma.
NAMPT-targeting PROTAC and nicotinic acid co-administration elicit safe and robust anti-tumor efficacy in NAPRT-deficient pan-cancers.
Exploiting Metabolic Defects in Glioma with Nanoparticle-Encapsulated NAMPT Inhibitors.
Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation.
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma.
Li L, Wang R, Zhu J, Cao F, Min J, Ouyang D, Lin L
Bioorganic chemistry 2026 Jan;168:109296
Bioorganic chemistry 2026 Jan;168:109296
NAD(+) Metabolism Reprogramming Drives SIRT1-Dependent Deacetylation Inducing PD-L1 Nuclear Localization in Cervical Cancer.
Lu X, Jin P, Tang Q, Zhou M, Xu H, Su C, Wang L, Xu F, Zhao M, Yin Y, Zhang J, Jia Z, Peng X, Zhou J, Wang L, Chen Y, Wang M, Yang M, Chen D, Chen Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2412109
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2412109
NAPRT Silencing in FH-Deficient Renal Cell Carcinoma Confers Therapeutic Vulnerabilities via NAD+ Depletion.
Noronha KJ, Lucas KN, Paradkar S, Edmonds J, Friedman S, Murray MA, Liu S, Sajed DP, Sachs C, Spurrier J, Raponi M, Liang J, Zeng H, Sundaram RK, Shuch B, Vasquez JC, Bindra RS
Molecular cancer research : MCR 2024 Oct 2;22(10):973-988
Molecular cancer research : MCR 2024 Oct 2;22(10):973-988
Discovery of potent and novel dual NAMPT/BRD4 inhibitors for efficient treatment of hepatocellular carcinoma.
Yin C, Jia S, Yang X, Wu L
European journal of medicinal chemistry 2024 May 5;271:116444
European journal of medicinal chemistry 2024 May 5;271:116444
NAMPT-targeting PROTAC and nicotinic acid co-administration elicit safe and robust anti-tumor efficacy in NAPRT-deficient pan-cancers.
Zhu X, Li Y, Liu H, Wang Y, Sun R, Jiang Z, Hou C, Hou X, Huang S, Zhang H, Wang H, Jiang B, Yang X, Xu B, Fan G
Cell chemical biology 2024 Jun 20;31(6):1203-1218.e17
Cell chemical biology 2024 Jun 20;31(6):1203-1218.e17
Exploiting Metabolic Defects in Glioma with Nanoparticle-Encapsulated NAMPT Inhibitors.
Murray MA, Noronha KJ, Wang Y, Friedman AP, Paradkar S, Suh HW, Sundaram RK, Brenner C, Saltzman WM, Bindra RS
Molecular cancer therapeutics 2024 Aug 1;23(8):1176-1187
Molecular cancer therapeutics 2024 Aug 1;23(8):1176-1187
Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation.
Managò A, Audrito V, Mazzola F, Sorci L, Gaudino F, Gizzi K, Vitale N, Incarnato D, Minazzato G, Ianniello A, Varriale A, D'Auria S, Mengozzi G, Politano G, Oliviero S, Raffaelli N, Deaglio S
Nature communications 2019 Sep 11;10(1):4116
Nature communications 2019 Sep 11;10(1):4116
PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma.
Fons NR, Sundaram RK, Breuer GA, Peng S, McLean RL, Kalathil AN, Schmidt MS, Carvalho DM, Mackay A, Jones C, Carcaboso ÁM, Nazarian J, Berens ME, Brenner C, Bindra RS
Nature communications 2019 Aug 22;10(1):3790
Nature communications 2019 Aug 22;10(1):3790
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 66159-1-Ig( NAPRT1 Antibody) at dilution of 1:1500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NAPRT1 antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human NAPRT1. This antibody recognizes human, mouse antigen. The NAPRT1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
