NAPRT

Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007). [supplied by OMIM, Mar 2008]

Description

Nicotinate phosphoribosyltransferase

Tissue specificity

Tissue enhanced (intestine, liver)

Subcell location

Nucleoplasm, Golgi apparatus, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

8:q24.3 (143574785 - 143578649)

Ensembl ID

ENSG00000147813  (ver. 103.38)

Orthologs

Mouse Naprt: ENSMUSG00000022574

UniProt

Q6XQN6

neXtProt

NX_Q6XQN6

Human splice variants
Mouse splice variants