PADI1

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

Description

Peptidyl arginine deiminase 1

Tissue specificity

Tissue enriched (esophagus)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

1 (17205128 - 17246007)

Ensembl ID

ENSG00000142623  (ver. 103.38)

Orthologs

Mouse Padi1: ENSMUSG00000025329

UniProt

Q9ULC6

neXtProt

NX_Q9ULC6

Human splice variants
Mouse splice variants

Protein structure