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antibody from Novus Biologicals
Targeting: ABCA1
ABC1, HDLDT1, TGD
Western blot
ELISA Immunocytochemistry Immunoprecipitation Immunohistochemistry Flow cytometry Blocking/Neutralizing Gel shift Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [334]
- Comments [0]
- Validations
- Western blot [7]
- Immunohistochemistry [2]
- Flow cytometry [3]
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- Product number
- NB400-105 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB400-105, RRID:AB_10000630
- Product name
- Rabbit Polyclonal ABCA1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human, Mouse, Rat, Canine, Chicken/Avian, Hamster, Porcine, Rabbit, Simian
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Caco-2 Cells for Measuring Intestinal Cholesterol Transport - Possibilities and Limitations.
THP-1 macrophage cholesterol efflux is impaired by palmitoleate through Akt activation.
4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters.
Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.
Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain.
Metabolomics study of the prefrontal cortex in a rat model of attention deficit hyperactivity disorder reveals the association between cholesterol metabolism disorder and hyperactive behavior.
Hesperidin blocks varenicline-aggravated atherosclerotic plaque formation in apolipoprotein E knockout mice by downregulating net uptake of oxidized low-density lipoprotein in macrophages.
Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism.
Soraphen A enhances macrophage cholesterol efflux via indirect LXR activation and ABCA1 upregulation.
Varenicline aggravates atherosclerotic plaque formation in nicotine-pretreated ApoE knockout mice due to enhanced oxLDL uptake by macrophages through downregulation of ABCA1 and ABCG1 expression.
Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis.
Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress.
Macrophage iron retention aggravates atherosclerosis: Evidence for the role of autocrine formation of hepcidin in plaque macrophages.
Butyrate protects against high-fat diet-induced atherosclerosis via up-regulating ABCA1 expression in apolipoprotein E-deficiency mice.
Ablation of miR-144 increases vimentin expression and atherosclerotic plaque formation.
Uteroplacental Insufficiency Impairs Cholesterol Elimination in Adult Female Growth-Restricted Rat Offspring Fed a High-Fat Diet.
Characterization of Redox-Responsive LXR-Activating Nanoparticle Formulations in Primary Mouse Macrophages.
A neutral lipid-enriched diet improves myelination and alleviates peripheral nerve pathology in neuropathic mice.
Anti-ApoA-1 IgGs in Familial Hypercholesterolemia Display Paradoxical Associations with Lipid Profile and Promote Foam Cell Formation.
Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages.
Eicosapentaenoic acid in combination with EPHA2 inhibition shows efficacy in preclinical models of triple-negative breast cancer by disrupting cellular cholesterol efflux.
The Stem Cell Phenotype of Aggressive Breast Cancer Cells.
Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration.
Common and Differential Transcriptional Actions of Nuclear Receptors Liver X Receptors α and β in Macrophages.
Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer.
Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease.
Pharmacological inhibition of the F1 -ATPase/P2Y1 pathway suppresses the effect of apolipoprotein A1 on endothelial nitric oxide synthesis and vasorelaxation.
Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells.
PMP22 Regulates Cholesterol Trafficking and ABCA1-Mediated Cholesterol Efflux.
Identification of Differential Roles of MicroRNA-33a and -33b During Atherosclerosis Progression With Genetically Modified Mice.
Nutritionally Derived Metabolic Cues Typical of the Obese Microenvironment Increase Cholesterol Efflux Capacity of Adipose Tissue Macrophages.
OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.
The long noncoding RNA CHROME regulates cholesterol homeostasis in primate.
p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression.
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.
Apolipoprotein A-I enhances insulin-dependent and insulin-independent glucose uptake by skeletal muscle.
MiR-33a is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons.
Brain Trauma Disrupts Hepatic Lipid Metabolism: Blame It on Fructose?
Cholesterol Acceptors Regulate the Lipidome of Macrophage Foam Cells.
Prenatal Exposure to a Maternal High Fat Diet Increases Hepatic Cholesterol Accumulation in Intrauterine Growth Restricted Rats in Part Through MicroRNA-122 Inhibition of Cyp7a1.
Liver X Receptor Agonist Therapy Prevents Diffuse Alveolar Hemorrhage in Murine Lupus by Repolarizing Macrophages.
Apolipoprotein A1 mimetic peptide ATI-5261 reverses arterial stiffness at late pregnancy and early postpartum in a COMT(-/-) mouse model of preeclampsia.
Overexpression of Salusin-α Inhibits Vascular Intimal Hyperplasia in an Atherosclerotic Rabbit Model.
E3317 promotes cholesterol efflux in macrophage cells via enhancing ABCA1 expression.
Directional ABCA1-mediated cholesterol efflux and apoB-lipoprotein secretion in the retinal pigment epithelium.
SREBF1/MicroRNA-33b Axis Exhibits Potent Effect on Unstable Atherosclerotic Plaque Formation In Vivo.
Positive association between cholesterol in human seminal plasma and sperm counts: results from a cross-sectional cohort study and immunohistochemical investigations.
Dysregulation of cardiac lipid parameters in high-fat high-cholesterol diet-induced rat model.
Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA.
Active liver X receptor signaling in phagocytes in multiple sclerosis lesions.
Ablating both Fabp1 and Scp2/Scpx (TKO) induces hepatic phospholipid and cholesterol accumulation in high fat-fed mice.
Adipose-Derived Exosomes Exert Proatherogenic Effects by Regulating Macrophage Foam Cell Formation and Polarization.
A critical role for ABC transporters in persistent lung inflammation in the development of emphysema after smoke exposure.
6-Dihydroparadol, a Ginger Constituent, Enhances Cholesterol Efflux from THP-1-Derived Macrophages.
SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.
Novel interactomics approach identifies ABCA1 as direct target of evodiamine, which increases macrophage cholesterol efflux.
Toll-like receptor 2 downregulates the cholesterol efflux by activating the nuclear factor-κB pathway in macrophages and may be a potential therapeutic target for the prevention of atherosclerosis.
Cholesterol metabolism and Cx43, Cx46, and Cx50 gap junction protein expression and localization in normal and diabetic and obese ob/ob and db/db mouse testes.
Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function.
Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer's disease.
Elastic aortic wrap reduced aortic stiffness by partially alleviating the impairment of cholesterol efflux capacity in pigs.
High-density lipoprotein mimetic peptide 4F mitigates amyloid-β-induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia.
Homocysteine accelerates atherosclerosis via inhibiting LXRα-mediated ABCA1/ABCG1-dependent cholesterol efflux from macrophages.
Temporary sequestration of cholesterol and phosphatidylcholine within extracellular domains of ABCA1 during nascent HDL generation.
Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells Attenuate Cigarette Smoke-Induced Cardiac Remodeling and Dysfunction.
Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene.
NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.
CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis.
The lipid moiety 7-ketocholesteryl-9-carboxynonanoate mediates binding interaction of oxLDL to LOX-1 and upregulates ABCA1 expression through PPARγ.
MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol.
Heat shock protein 27-derived atheroprotection involves reverse cholesterol transport that is dependent on GM-CSF to maintain ABCA1 and ABCG1 expression in ApoE-/- mice.
Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway.
Activation of PPARγ does not contribute to macrophage ABCA1 expression and ABCA1-mediated cholesterol efflux to apoAI.
ATP binding cassette A1 (ABCA1) mediates microparticle formation during high-density lipoprotein (HDL) biogenesis.
Hawthorn (Crataegus pinnatifida Bunge) leave flavonoids attenuate atherosclerosis development in apoE knock-out mice.
Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease.
Regulated efflux of photoreceptor outer segment-derived cholesterol by human RPE cells.
Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP-1-derived macrophages.
Bilirubin Decreases Macrophage Cholesterol Efflux and ATP-Binding Cassette Transporter A1 Protein Expression.
Cortistatin reduces atherosclerosis in hyperlipidemic ApoE-deficient mice and the formation of foam cells.
M1- and M2-Type Macrophage Responses Are Predictive of Adverse Outcomes in Human Atherosclerosis.
Dietary high cholesterol and trace metals in the drinking water increase levels of ABCA1 in the rabbit hippocampus and temporal cortex.
Ajwa Date (Phoenix dactylifera L.) Extract Inhibits Human Breast Adenocarcinoma (MCF7) Cells In Vitro by Inducing Apoptosis and Cell Cycle Arrest.
Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins.
AMPK activates LXRα and ABCA1 expression in human macrophages.
Quercetin stabilizes apolipoprotein E and reduces brain Aβ levels in amyloid model mice.
MicroRNA-33 Regulates the Innate Immune Response via ATP Binding Cassette Transporter-mediated Remodeling of Membrane Microdomains.
Triptolide inhibits the progression of atherosclerosis in apolipoprotein E(-)/(-) mice.
Inhibition of apolipoprotein B synthesis stimulates endoplasmic reticulum autophagy that prevents steatosis.
Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages.
Ursolic acid enhances macrophage autophagy and attenuates atherogenesis.
MiR-33a Decreases High-Density Lipoprotein-Induced Radiation Sensitivity in Breast Cancer.
Smooth Muscle Cell Foam Cell Formation, Apolipoproteins, and ABCA1 in Intracranial Aneurysms: Implications for Lipid Accumulation as a Promoter of Aneurysm Wall Rupture.
Intrauterine growth restriction combined with a maternal high-fat diet increases hepatic cholesterol and low-density lipoprotein receptor activity in rats.
Allogeneic Mesenchymal Stromal Cells Overexpressing Mutant Human Hypoxia-Inducible Factor 1-α (HIF1-α) in an Ovine Model of Acute Myocardial Infarction.
9-cis β-Carotene Increased Cholesterol Efflux to HDL in Macrophages.
TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis.
Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophages.
Lanatoside C Promotes Foam Cell Formation and Atherosclerosis.
Difference in expression patterns of placental cholesterol transporters, ABCA1 and SR-BI, in Meishan and Yorkshire pigs with different placental efficiency.
miR-145 Regulates Diabetes-Bone Marrow Stromal Cell-Induced Neurorestorative Effects in Diabetes Stroke Rats.
Seminal Plasma Characteristics and Expression of ATP-binding Cassette Transporter A1 (ABCA1) in Canine Spermatozoa from Ejaculates with Good and Bad Freezability.
Eicosapentaenoic acid membrane incorporation impairs ABCA1-dependent cholesterol efflux via a protein kinase A signaling pathway in primary human macrophages.
The cholesterol transporter ABCA1 is expressed in stallion spermatozoa and reproductive tract tissues.
Hypermethylation of the TGF-β target, ABCA1 is associated with poor prognosis in ovarian cancer patients.
LXR-Mediated ABCA1 Expression and Function Are Modulated by High Glucose and PRMT2.
Stimulation of Liver X Receptor Has Potent Anti-HIV Effects in a Humanized Mouse Model of HIV Infection.
Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease.
Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells.
Enolase is regulated by Liver X Receptors.
LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling.
Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1.
RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes.
Purple perilla extracts with α-asarone enhance cholesterol efflux from oxidized LDL-exposed macrophages.
Sparstolonin B suppresses rat vascular smooth muscle cell proliferation, migration, inflammatory response and lipid accumulation.
Up-regulation of the ATP-binding cassette transporter A1 inhibits hepatitis C virus infection.
Vasoprotective effects of urocortin 1 against atherosclerosis in vitro and in vivo.
Akt inhibition promotes ABCA1-mediated cholesterol efflux to ApoA-I through suppressing mTORC1.
Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo.
Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance.
The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice.
Cubilin maintains blood levels of HDL and albumin.
Fumigaclavine C activates PPARγ pathway and attenuates atherogenesis in ApoE-deficient mice.
Pentraxin 3 promotes oxLDL uptake and inhibits cholesterol efflux from macrophage-derived foam cells.
The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis.
Immunolocalization of the cholesterol transporters ABCA1 and ABCG1 in canine reproductive tract tissues and spermatozoa.
7-ketocholesteryl-9-carboxynonanoate enhances ATP binding cassette transporter A1 expression mediated by PPARγ in THP-1 macrophages.
miR-206 controls LXRα expression and promotes LXR-mediated cholesterol efflux in macrophages.
MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo.
Expression of liver X receptor correlates with intrahepatic inflammation and fibrosis in patients with nonalcoholic fatty liver disease.
Inhibition of atherosclerosis-promoting microRNAs via targeted polyelectrolyte complex micelles.
Rutaecarpine suppresses atherosclerosis in ApoE-/- mice through upregulating ABCA1 and SR-BI within RCT.
Identification of a selective agonist for liver X receptor α (LXRα) via screening of a synthetic compound library.
Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis.
Inhibition of mitogen-activated protein kinase Erk1/2 promotes protein degradation of ATP binding cassette transporters A1 and G1 in CHO and HuH7 cells.
Lack of liver X receptors leads to cell proliferation in a model of mouse dorsal prostate epithelial cell.
Osbpl8 deficiency in mouse causes an elevation of high-density lipoproteins and gender-specific alterations of lipid metabolism.
Bone marrow deficiency of MCPIP1 results in severe multi-organ inflammation but diminishes atherogenesis in hyperlipidemic mice.
MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice.
Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death.
ABC transporter activity linked to radiation resistance and molecular subtype in pediatric medulloblastoma.
Placental ABCA1 and ABCG1 expression in gestational disease: Pre-eclampsia affects ABCA1 levels in syncytiotrophoblasts.
Quercetin-3-O-glucuronide induces ABCA1 expression by LXRα activation in murine macrophages.
Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice.
Lymphatic vessels are essential for the removal of cholesterol from peripheral tissues by SR-BI-mediated transport of HDL.
DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism.
Liver X receptors inhibit proliferation of human colorectal cancer cells and growth of intestinal tumors in mice.
MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor.
Factors controlling nascent high-density lipoprotein particle heterogeneity: ATP-binding cassette transporter A1 activity and cell lipid and apolipoprotein AI availability.
Differential regulation of gene expression by LXRs in response to macrophage cholesterol loading.
Knock-down of the oxysterol receptor LXRα impairs cholesterol efflux in human primary macrophages: lack of compensation by LXRβ activation.
Molecular mechanisms responsible for the reduced expression of cholesterol transporters from macrophages by low-dose endotoxin.
Advanced glycated albumin isolated from poorly controlled type 1 diabetes mellitus patients alters macrophage gene expression impairing ABCA-1-mediated reverse cholesterol transport.
TLR2 stimulates ABCA1 expression via PKC-η and PLD2 pathway.
Apelin-13 increases expression of ATP-binding cassette transporter A1 via activating protein kinase C α signaling in THP-1 macrophage-derived foam cells.
Cholesterol efflux is differentially regulated in neurons and astrocytes: implications for brain cholesterol homeostasis.
Targeting GGTase-I activates RHOA, increases macrophage reverse cholesterol transport, and reduces atherosclerosis in mice.
Dysregulation of cholesterol homeostasis in human prostate cancer through loss of ABCA1.
The combination of L-4F and simvastatin stimulate cholesterol efflux and related proteins expressions to reduce atherosclerotic lesions in apoE knockout mice.
The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation.
Differential regulation of ABCA1 and macrophage cholesterol efflux by elaidic and oleic acids.
The nuclear receptor LXRα controls the functional specialization of splenic macrophages.
Synthesis and identification of new flavonoids targeting liver X receptor β involved pathway as potential facilitators of Aβ clearance with reduced lipid accumulation.
IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor.
Intestine-specific Mttp deletion decreases mortality and prevents sepsis-induced intestinal injury in a murine model of Pseudomonas aeruginosa pneumonia.
Efficacy of a therapeutic vaccine using mutated β-amyloid sensitized dendritic cells in Alzheimer's mice.
miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity.
Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2.
Omega-6 polyunsaturated fatty acids prevent atherosclerosis development in LDLr-KO mice, in spite of displaying a pro-inflammatory profile similar to trans fatty acids.
Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype.
Host HDL biogenesis machinery is recruited to the inclusion of Chlamydia trachomatis-infected cells and regulates chlamydial growth.
Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis.
Modulation of lipid metabolism with the overexpression of NPC1L1 in mouse liver.
Loss of liver FA binding protein significantly alters hepatocyte plasma membrane microdomains.
Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells.
ABCA1-dependent mobilization of lysosomal cholesterol requires functional Niemann-Pick C2 but not Niemann-Pick C1 protein.
Acyl-CoA synthetase 1 is required for oleate and linoleate mediated inhibition of cholesterol efflux through ATP-binding cassette transporter A1 in macrophages.
Phospholipase A(2)-modified low-density lipoprotein activates liver X receptor in human macrophages.
PAPP-A negatively regulates ABCA1, ABCG1 and SR-B1 expression by inhibiting LXRα through the IGF-I-mediated signaling pathway.
ER stress is associated with reduced ABCA-1 protein levels in macrophages treated with advanced glycated albumin - reversal by a chemical chaperone.
Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease.
Loss of Niemann Pick type C proteins 1 and 2 greatly enhances HIV infectivity and is associated with accumulation of HIV Gag and cholesterol in late endosomes/lysosomes.
Lipid-bound apolipoproteins in tyrosyl radical-oxidized HDL stabilize ABCA1 like lipid-free apolipoprotein A-I.
Deleterious impact of elaidic fatty acid on ABCA1-mediated cholesterol efflux from mouse and human macrophages.
Liver X receptor β and peroxisome proliferator-activated receptor δ regulate cholesterol transport in murine cholangiocytes.
Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1.
MicroRNA-33 deficiency reduces the progression of atherosclerotic plaque in ApoE-/- mice.
Mitochondrial DNA polymorphisms specifically modify cerebral β-amyloid proteostasis.
Effect of 6-O-α-maltosyl-β cyclodextrin and its cholesterol inclusion complex on cellular cholesterol levels and ABCA1 and ABCG1 expression in mouse mastocytoma P-815 cells.
HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux.
Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action.
Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages.
Intracellular cholesterol-binding proteins enhance HDL-mediated cholesterol uptake in cultured primary mouse hepatocytes.
Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux.
Mifepristone treatment results in differential regulation of glycerolipid biosynthesis in baby hamster kidney cells expressing a mifepristone-inducible ABCA1.
Retinoic acid isomers up-regulate ATP binding cassette A1 and G1 and cholesterol efflux in rat astrocytes: implications for their therapeutic and teratogenic effects.
Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice.
ABCA1 increases extracellular ATP to mediate cholesterol efflux to ApoA-I.
Membrane microdomains modulate oligomeric ABCA1 function: impact on apoAI-mediated lipid removal and phosphatidylcholine biosynthesis.
Mycophenolic acid induces ATP-binding cassette transporter A1 (ABCA1) expression through the PPARγ-LXRα-ABCA1 pathway.
13-hydroxy linoleic acid increases expression of the cholesterol transporters ABCA1, ABCG1 and SR-BI and stimulates apoA-I-dependent cholesterol efflux in RAW264.7 macrophages.
Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.
Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target.
Expression and localization pattern of ABCA1 in diverse human placental primary cells and tissues.
Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cells.
Modulation of ABCA1 by an LXR agonist reduces β-amyloid levels and improves outcome after traumatic brain injury.
Ht31, a protein kinase A anchoring inhibitor, induces robust cholesterol efflux and reverses macrophage foam cell formation through ATP-binding cassette transporter A1.
Modulation of macrophage fatty acid content and composition by exposure to dyslipidemic serum in vitro.
ABCA1 promotes the efflux of bacterial LPS from macrophages and accelerates recovery from LPS-induced tolerance.
Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity.
HAATI survivors replace canonical telomeres with blocks of generic heterochromatin.
Characterization of apoA-I-dependent lipid efflux from adipocytes and role of ABCA1.
The structural basis for membrane binding and pore formation by lymphocyte perforin.
The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro.
IL-33 reduces macrophage foam cell formation.
The reverse cholesterol transport system as a potential mediator of luteolysis in the primate corpus luteum.
Liver X receptor agonist inhibits proliferation of ovarian carcinoma cells stimulated by oxidized low density lipoprotein.
Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia.
The liver-selective thyromimetic T-0681 influences reverse cholesterol transport and atherosclerosis development in mice.
Liver X receptor agonist treatment reduced splanchnic ischemia and reperfusion injury.
Enhanced aortic macrophage lipid accumulation and inflammatory response in LDL receptor null mice fed an atherogenic diet.
SR-BI, CD36, and caveolin-1 contribute positively to cholesterol efflux in hepatic cells.
Vitamin A deficiency results in dysregulation of lipid efflux pathway in rat kidney.
High glucose promotes intracellular lipid accumulation in vascular smooth muscle cells by impairing cholesterol influx and efflux balance.
LXR regulate cholesterol homeostasis in the proximal mouse epididymis.
LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner.
A novel missense mutation of ABCA1 in transmembrane alpha-helix in a Japanese patient with Tangier disease.
Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2.
An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2.
The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor.
ABCA1-mediated cholesterol efflux generates microparticles in addition to HDL through processes governed by membrane rigidity.
Defects in the regulatory clearance mechanisms favor the breakdown of self-tolerance during spontaneous autoimmune orchitis.
Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile.
Renal mass reduction results in accumulation of lipids and dysregulation of lipid regulatory proteins in the remnant kidney.
Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in mice.
Serum, but not monocyte macrophage foam cells derived from low HDL-C subjects, displays reduced cholesterol efflux capacity.
Expression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium.
Leptin modulates ACAT1 expression and cholesterol efflux from human macrophages.
Insulin stimulates the expression of carbohydrate response element binding protein (ChREBP) by attenuating the repressive effect of Pit-1, Oct-1/Oct-2, and Unc-86 homeodomain protein octamer transcription factor-1.
Dietary soy protein isolate attenuates metabolic syndrome in rats via effects on PPAR, LXR, and SREBP signaling.
In vitro fatty acid enrichment of macrophages alters inflammatory response and net cholesterol accumulation.
Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis.
CD36-mediated cholesterol efflux is associated with PPARgamma activation via a MAPK-dependent COX-2 pathway in macrophages.
Thieno[2,3-c]isoquinolin-5-one, a potent poly(ADP-ribose) polymerase inhibitor, promotes atherosclerotic plaque regression in high-fat diet-fed apolipoprotein E-deficient mice: effects on inflammatory markers and lipid content.
Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis.
Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain.
A novel enzyme immunoassay specific for ABCA1 protein quantification in human tissues and cells.
Enhancing apolipoprotein A-I-dependent cholesterol efflux elevates cholesterol export from macrophages in vivo.
Antiatherosclerotic effects of a novel synthetic tissue-selective steroidal liver X receptor agonist in low-density lipoprotein receptor-deficient mice.
LXR-induced reverse cholesterol transport in human airway smooth muscle is mediated exclusively by ABCA1.
Intestinal fatty acid binding protein regulates mitochondrion beta-oxidation and cholesterol uptake.
alpha-Tocopherol disturbs macrophage LXRalpha regulation of ABCA1/G1 and cholesterol handling.
Interferon-gamma reduces cell surface expression of annexin 2 and suppresses the invasive capacity of prostate cancer cells.
Expression and biological activity of ABCA1 in alveolar epithelial cells.
Laminar shear stress regulates liver X receptor in vascular endothelial cells.
Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense.
Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense.
Cholesterol transporter ATP-binding cassette A1 (ABCA1) is elevated in prion disease and affects PrPC and PrPSc concentrations in cultured cells.
Endoglin (CD105) expression is regulated by the liver X receptor alpha (NR1H3) in human trophoblast cell line JAR.
Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux.
OSBP negatively regulates ABCA1 protein stability.
Role of caveolin-1 in the regulation of lipoprotein metabolism.
Reduced plasma high-density lipoprotein cholesterol in hyperthyroid mice coincides with decreased hepatic adenosine 5'-triphosphate-binding cassette transporter 1 expression.
OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages.
Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1.
Hepatic CTP:phosphocholine cytidylyltransferase-alpha is a critical predictor of plasma high density lipoprotein and very low density lipoprotein.
Genetic deletion of low density lipoprotein receptor impairs sterol-induced mouse macrophage ABCA1 expression. A new SREBP1-dependent mechanism.
Impact of salusin-alpha and -beta on human macrophage foam cell formation and coronary atherosclerosis.
Ritonavir increases CD36, ABCA1 and CYP27 expression in THP-1 macrophages.
A role for hepatic scavenger receptor class B, type I in decreasing high density lipoprotein levels in mice that lack phosphatidylethanolamine N-methyltransferase.
ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain.
Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.
Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells.
SCP-2/SCP-x gene ablation alters lipid raft domains in primary cultured mouse hepatocytes.
The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis.
Identification of an ABCA1-dependent phospholipid-rich plasma membrane apolipoprotein A-I binding site for nascent HDL formation: implications for current models of HDL biogenesis.
Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors.
ABCA1, ABCG1 and SR-BI: hormonal regulation in primary rat hepatocytes and human cell lines.
Chenodeoxycholic acid suppresses the activation of acetyl-coenzyme A carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317.
NO-1886 upregulates ATP binding cassette transporter A1 and inhibits diet-induced atherosclerosis in Chinese Bama minipigs.
Leukocyte transglutaminase 2 expression limits atherosclerotic lesion size.
Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice.
Adenovirus-mediated overexpression of sphingomyelin synthases 1 and 2 increases the atherogenic potential in mice.
IGF-1 induces rat glomerular mesangial cells to accumulate triglyceride.
TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells.
Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I.
Transcriptional repression of ATP-binding cassette transporter A1 gene in macrophages: a novel atherosclerotic effect of angiotensin II.
Knockdown of hepatic ABCA1 by RNA interference decreases plasma HDL cholesterol levels and influences postprandial lipemia in mice.
Glycosphingolipid accumulation inhibits cholesterol efflux via the ABCA1/apolipoprotein A-I pathway: 1-phenyl-2-decanoylamino-3-morpholino-1-propanol is a novel cholesterol efflux accelerator.
ACAT1 deficiency disrupts cholesterol efflux and alters cellular morphology in macrophages.
The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease.
Genes of cholesterol metabolism in human atheroma: overexpression of perilipin and genes promoting cholesterol storage and repression of ABCA1 expression.
The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities.
Effects of pravastatin on the expression of ATP-binding cassette transporter A1.
Characterization of oligomeric human ATP binding cassette transporter A1. Potential implications for determining the structure of nascent high density lipoprotein particles.
Cellular physiology of cholesterol efflux in vascular endothelial cells.
Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism.
LXR/RXR ligand activation enhances basolateral efflux of beta-sitosterol in CaCo-2 cells.
Molecular interactions between apoE and ABCA1: impact on apoE lipidation.
Apolipoprotein A-1 interaction with plasma membrane lipid rafts controls cholesterol export from macrophages.
Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter.
ABCA1-dependent lipid efflux to apolipoprotein A-I mediates HDL particle formation and decreases VLDL secretion from murine hepatocytes.
Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1).
Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells.
Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma.
Oxysterols trigger ABCA1-mediated basolateral surfactant efflux.
Differential expression of cholesterol hydroxylases in Alzheimer's disease.
Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR.
Macrophage apolipoprotein A-I expression protects against atherosclerosis in ApoE-deficient mice and up-regulates ABC transporters.
Macrophage apolipoprotein A-I expression protects against atherosclerosis in ApoE-deficient mice and up-regulates ABC transporters.
Identification and characterization of rodent ABCA1 in isolated type II pneumocytes.
Ceramide enhances cholesterol efflux to apolipoprotein A-I by increasing the cell surface presence of ATP-binding cassette transporter A1.
Expression of sterol 27-hydroxylase (CYP27A1) enhances cholesterol efflux.
Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion.
Experimental glomerulopathy alters renal cortical cholesterol, SR-B1, ABCA1, and HMG CoA reductase expression.
A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I.
Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations.
T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice.
T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice.
Proximal tubular cholesterol loading after mitochondrial, but not glycolytic, blockade.
Visualizing lipid structure and raft domains in living cells with two-photon microscopy.
Regulation of ABCA1 expression and cholesterol efflux during adipose differentiation of 3T3-L1 cells.
Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression.
Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression.
22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion.
ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity.
ATP-binding cassette transporter 1 participates in LDL oxidation by artery wall cells.
ATP-binding cassette transporter 1 participates in LDL oxidation by artery wall cells.
LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells.
LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells.
cAMP induces ABCA1 phosphorylation activity and promotes cholesterol efflux from fibroblasts.
cAMP induces ABCA1 phosphorylation activity and promotes cholesterol efflux from fibroblasts.
Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels.
Trypsin-sensitive and lipid-containing sites of the macrophage extracellular matrix bind apolipoprotein A-I and participate in ABCA1-dependent cholesterol efflux.
Hiebl V, Schachner D, Ladurner A, Heiss EH, Stangl H, Dirsch VM
Biological procedures online 2020;22:7
Biological procedures online 2020;22:7
THP-1 macrophage cholesterol efflux is impaired by palmitoleate through Akt activation.
Marshall JD, Courage ER, Elliott RF, Fitzpatrick MN, Kim AD, Lopez-Clavijo AF, Woolfrey BA, Ouimet M, Wakelam MJO, Brown RJ
PloS one 2020;15(5):e0233180
PloS one 2020;15(5):e0233180
4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters.
Salonurmi T, Nabil H, Ronkainen J, Hyötyläinen T, Hautajärvi H, Savolainen MJ, Tolonen A, Orešič M, Känsäkoski P, Rysä J, Hakkola J, Hukkanen J
Frontiers in pharmacology 2020;11:361
Frontiers in pharmacology 2020;11:361
Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells.
Matsuda J, Takahashi A, Takabatake Y, Sakai S, Minami S, Yamamoto T, Fujimura R, Namba-Hamano T, Yonishi H, Nakamura J, Kimura T, Kaimori JY, Matsui I, Takahashi M, Nakao M, Izumi Y, Bamba T, Matsusaka T, Niimura F, Yanagita M, Yoshimori T, Isaka Y
Autophagy 2020 Oct;16(10):1889-1904
Autophagy 2020 Oct;16(10):1889-1904
Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain.
Bogie JFJ, Grajchen E, Wouters E, Corrales AG, Dierckx T, Vanherle S, Mailleux J, Gervois P, Wolfs E, Dehairs J, Van Broeckhoven J, Bowman AP, Lambrichts I, Gustafsson JÅ, Remaley AT, Mulder M, Swinnen JV, Haidar M, Ellis SR, Ntambi JM, Zelcer N, Hendriks JJA
The Journal of experimental medicine 2020 May 4;217(5)
The Journal of experimental medicine 2020 May 4;217(5)
Metabolomics study of the prefrontal cortex in a rat model of attention deficit hyperactivity disorder reveals the association between cholesterol metabolism disorder and hyperactive behavior.
Chen T, Yuan H, Sun YB, Song YC, Lu M, Ni X, Han X
Biochemical and biophysical research communications 2020 Mar 5;523(2):315-321
Biochemical and biophysical research communications 2020 Mar 5;523(2):315-321
Hesperidin blocks varenicline-aggravated atherosclerotic plaque formation in apolipoprotein E knockout mice by downregulating net uptake of oxidized low-density lipoprotein in macrophages.
Koga M, Kanaoka Y, Inada K, Omine S, Kataoka Y, Yamauchi A
Journal of pharmacological sciences 2020 Jun;143(2):106-111
Journal of pharmacological sciences 2020 Jun;143(2):106-111
Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism.
Pathak P, Helsley RN, Brown AL, Buffa JA, Choucair I, Nemet I, Gogonea CB, Gogonea V, Wang Z, Garcia-Garcia JC, Cai L, Temel R, Sangwan N, Hazen SL, Brown JM
American journal of physiology. Heart and circulatory physiology 2020 Jun 1;318(6):H1474-H1486
American journal of physiology. Heart and circulatory physiology 2020 Jun 1;318(6):H1474-H1486
Soraphen A enhances macrophage cholesterol efflux via indirect LXR activation and ABCA1 upregulation.
Wang D, Hiebl V, Schachner D, Ladurner A, Heiss EH, Atanasov AG, Dirsch VM
Biochemical pharmacology 2020 Jul;177:114022
Biochemical pharmacology 2020 Jul;177:114022
Varenicline aggravates atherosclerotic plaque formation in nicotine-pretreated ApoE knockout mice due to enhanced oxLDL uptake by macrophages through downregulation of ABCA1 and ABCG1 expression.
Koga M, Kanaoka Y, Okamoto M, Nakao Y, Inada K, Takayama S, Kataoka Y, Yamauchi A
Journal of pharmacological sciences 2020 Jan;142(1):9-15
Journal of pharmacological sciences 2020 Jan;142(1):9-15
Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis.
Xu Y, Xu Y, Zhu Y, Sun H, Juguilon C, Li F, Fan D, Yin L, Zhang Y
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Jan 8;28(1):202-216
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Jan 8;28(1):202-216
Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress.
Kaymak I, Maier CR, Schmitz W, Campbell AD, Dankworth B, Ade CP, Walz S, Paauwe M, Kalogirou C, Marouf H, Rosenfeldt MT, Gay DM, McGregor GH, Sansom OJ, Schulze A
Cancer research 2020 Jan 15;80(2):189-203
Cancer research 2020 Jan 15;80(2):189-203
Macrophage iron retention aggravates atherosclerosis: Evidence for the role of autocrine formation of hepcidin in plaque macrophages.
Xiao L, Luo G, Guo X, Jiang C, Zeng H, Zhou F, Li Y, Yu J, Yao P
Biochimica et biophysica acta. Molecular and cell biology of lipids 2020 Feb;1865(2):158531
Biochimica et biophysica acta. Molecular and cell biology of lipids 2020 Feb;1865(2):158531
Butyrate protects against high-fat diet-induced atherosclerosis via up-regulating ABCA1 expression in apolipoprotein E-deficiency mice.
Du Y, Li X, Su C, Xi M, Zhang X, Jiang Z, Wang L, Hong B
British journal of pharmacology 2020 Apr;177(8):1754-1772
British journal of pharmacology 2020 Apr;177(8):1754-1772
Ablation of miR-144 increases vimentin expression and atherosclerotic plaque formation.
He Q, Wang F, Honda T, Greis KD, Redington AN
Scientific reports 2020 Apr 9;10(1):6127
Scientific reports 2020 Apr 9;10(1):6127
Uteroplacental Insufficiency Impairs Cholesterol Elimination in Adult Female Growth-Restricted Rat Offspring Fed a High-Fat Diet.
Zinkhan EK, Yu B, McKnight R
Reproductive sciences (Thousand Oaks, Calif.) 2019 Sep;26(9):1173-1180
Reproductive sciences (Thousand Oaks, Calif.) 2019 Sep;26(9):1173-1180
Characterization of Redox-Responsive LXR-Activating Nanoparticle Formulations in Primary Mouse Macrophages.
Smith TKT, Kahiel Z, LeBlond ND, Ghorbani P, Farah E, Al-Awosi R, Cote M, Gadde S, Fullerton MD
Molecules (Basel, Switzerland) 2019 Oct 18;24(20)
Molecules (Basel, Switzerland) 2019 Oct 18;24(20)
A neutral lipid-enriched diet improves myelination and alleviates peripheral nerve pathology in neuropathic mice.
Zhou Y, Bazick H, Miles JR, Fethiere AI, Salihi MOA, Fazio S, Tavori H, Notterpek L
Experimental neurology 2019 Nov;321:113031
Experimental neurology 2019 Nov;321:113031
Anti-ApoA-1 IgGs in Familial Hypercholesterolemia Display Paradoxical Associations with Lipid Profile and Promote Foam Cell Formation.
Pagano S, Magenta A, D'Agostino M, Martino F, Barillà F, Satta N, Frias MA, Ronca A, Mach F, Gencer B, Favari E, Vuilleumier N
Journal of clinical medicine 2019 Nov 21;8(12)
Journal of clinical medicine 2019 Nov 21;8(12)
Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages.
Vaidya M, Jentsch JA, Peters S, Keul P, Weske S, Gräler MH, Mladenov E, Iliakis G, Heusch G, Levkau B
Journal of lipid research 2019 Mar;60(3):506-515
Journal of lipid research 2019 Mar;60(3):506-515
Eicosapentaenoic acid in combination with EPHA2 inhibition shows efficacy in preclinical models of triple-negative breast cancer by disrupting cellular cholesterol efflux.
Torres-Adorno AM, Vitrac H, Qi Y, Tan L, Levental KR, Fan YY, Yang P, Chapkin RS, Eckhardt BL, Ueno NT
Oncogene 2019 Mar;38(12):2135-2150
Oncogene 2019 Mar;38(12):2135-2150
The Stem Cell Phenotype of Aggressive Breast Cancer Cells.
Margaryan NV, Hazard-Jenkins H, Salkeni MA, Smolkin MB, Coad JA, Wen S, Seftor EA, Seftor REB, Hendrix MJC
Cancers 2019 Mar 8;11(3)
Cancers 2019 Mar 8;11(3)
Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration.
Storti F, Klee K, Todorova V, Steiner R, Othman A, van der Velde-Visser S, Samardzija M, Meneau I, Barben M, Karademir D, Pauzuolyte V, Boye SL, Blaser F, Ullmer C, Dunaief JL, Hornemann T, Rohrer L, den Hollander A, von Eckardstein A, Fingerle J, Maugeais C, Grimm C
eLife 2019 Mar 13;8
eLife 2019 Mar 13;8
Common and Differential Transcriptional Actions of Nuclear Receptors Liver X Receptors α and β in Macrophages.
Ramón-Vázquez A, de la Rosa JV, Tabraue C, Lopez F, Díaz-Chico BN, Bosca L, Tontonoz P, Alemany S, Castrillo A
Molecular and cellular biology 2019 Mar 1;39(5)
Molecular and cellular biology 2019 Mar 1;39(5)
Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer.
Tiwari P, Blank A, Cui C, Schoenfelt KQ, Zhou G, Xu Y, Khramtsova G, Olopade F, Shah AM, Khan SA, Rosner MR, Becker L
The Journal of experimental medicine 2019 Jun 3;216(6):1345-1358
The Journal of experimental medicine 2019 Jun 3;216(6):1345-1358
Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease.
Ahn SB, Jun DW, Jang K, Lee BH, Shin KJ
The Korean journal of internal medicine 2019 Jul;34(4):777-784
The Korean journal of internal medicine 2019 Jul;34(4):777-784
Pharmacological inhibition of the F1 -ATPase/P2Y1 pathway suppresses the effect of apolipoprotein A1 on endothelial nitric oxide synthesis and vasorelaxation.
Cabou C, Honorato P, Briceño L, Ghezali L, Duparc T, León M, Combes G, Frayssinhes L, Fournel A, Abot A, Masri B, Parada N, Aguilera V, Aguayo C, Knauf C, González M, Radojkovic C, Martinez LO
Acta physiologica (Oxford, England) 2019 Jul;226(3):e13268
Acta physiologica (Oxford, England) 2019 Jul;226(3):e13268
Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells.
Mukhamedova N, Hoang A, Dragoljevic D, Dubrovsky L, Pushkarsky T, Low H, Ditiatkovski M, Fu Y, Ohkawa R, Meikle PJ, Horvath A, Brichacek B, Miller YI, Murphy A, Bukrinsky M, Sviridov D
PLoS pathogens 2019 Jul;15(7):e1007907
PLoS pathogens 2019 Jul;15(7):e1007907
PMP22 Regulates Cholesterol Trafficking and ABCA1-Mediated Cholesterol Efflux.
Zhou Y, Miles JR, Tavori H, Lin M, Khoshbouei H, Borchelt DR, Bazick H, Landreth GE, Lee S, Fazio S, Notterpek L
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jul 3;39(27):5404-5418
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jul 3;39(27):5404-5418
Identification of Differential Roles of MicroRNA-33a and -33b During Atherosclerosis Progression With Genetically Modified Mice.
Koyama S, Horie T, Nishino T, Baba O, Sowa N, Miyasaka Y, Kuwabara Y, Nakao T, Nishiga M, Nishi H, Nakashima Y, Nakazeki F, Ide Y, Kimura M, Tsuji S, Ruiz Rodriguez R, Xu S, Yamasaki T, Otani C, Watanabe T, Nakamura T, Hasegawa K, Kimura T, Ono K
Journal of the American Heart Association 2019 Jul 2;8(13):e012609
Journal of the American Heart Association 2019 Jul 2;8(13):e012609
Nutritionally Derived Metabolic Cues Typical of the Obese Microenvironment Increase Cholesterol Efflux Capacity of Adipose Tissue Macrophages.
O'Reilly ME, Kajani S, Ralston JC, Lenighan YM, Roche HM, McGillicuddy FC
Molecular nutrition & food research 2019 Jan;63(2):e1800713
Molecular nutrition & food research 2019 Jan;63(2):e1800713
OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice.
Yuan C, Guo X, Zhou Q, Du F, Jiang W, Zhou X, Liu P, Chi T, Ji X, Gao J, Chen C, Lang H, Xu J, Liu D, Yang Y, Qiu S, Tang X, Chen G, Zou L
Biochimica et biophysica acta. Molecular basis of disease 2019 Jan;1865(1):161-180
Biochimica et biophysica acta. Molecular basis of disease 2019 Jan;1865(1):161-180
The long noncoding RNA CHROME regulates cholesterol homeostasis in primate.
Hennessy EJ, van Solingen C, Scacalossi KR, Ouimet M, Afonso MS, Prins J, Koelwyn GJ, Sharma M, Ramkhelawon B, Carpenter S, Busch A, Chernogubova E, Matic LP, Hedin U, Maegdefessel L, Caffrey BE, Hussein MA, Ricci EP, Temel RE, Garabedian MJ, Berger JS, Vickers KC, Kanke M, Sethupathy P, Teupser D, Holdt LM, Moore KJ
Nature metabolism 2019 Jan;1(1):98-110
Nature metabolism 2019 Jan;1(1):98-110
p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression.
Moon SH, Huang CH, Houlihan SL, Regunath K, Freed-Pastor WA, Morris JP 4th, Tschaharganeh DF, Kastenhuber ER, Barsotti AM, Culp-Hill R, Xue W, Ho YJ, Baslan T, Li X, Mayle A, de Stanchina E, Zender L, Tong DR, D'Alessandro A, Lowe SW, Prives C
Cell 2019 Jan 24;176(3):564-580.e19
Cell 2019 Jan 24;176(3):564-580.e19
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.
Zhong S, Li L, Zhang YL, Zhang L, Lu J, Guo S, Liang N, Ge J, Zhu M, Tao Y, Wu YC, Yin H
The Journal of clinical investigation 2019 Jan 2;129(1):252-267
The Journal of clinical investigation 2019 Jan 2;129(1):252-267
Apolipoprotein A-I enhances insulin-dependent and insulin-independent glucose uptake by skeletal muscle.
Tang S, Tabet F, Cochran BJ, Cuesta Torres LF, Wu BJ, Barter PJ, Rye KA
Scientific reports 2019 Feb 4;9(1):1350
Scientific reports 2019 Feb 4;9(1):1350
MiR-33a is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons.
Nakazeki F, Tsuge I, Horie T, Imamura K, Tsukita K, Hotta A, Baba O, Kuwabara Y, Nishino T, Nakao T, Nishiga M, Nishi H, Nakashima Y, Ide Y, Koyama S, Kimura M, Tsuji S, Naitoh M, Suzuki S, Izumi Y, Kawarai T, Kaji R, Kimura T, Inoue H, Ono K
Clinical science (London, England : 1979) 2019 Feb 28;133(4):583-595
Clinical science (London, England : 1979) 2019 Feb 28;133(4):583-595
Brain Trauma Disrupts Hepatic Lipid Metabolism: Blame It on Fructose?
Rege SD, Royes L, Tsai B, Zhang G, Yang X, Gomez-Pinilla F
Molecular nutrition & food research 2019 Aug;63(15):e1801054
Molecular nutrition & food research 2019 Aug;63(15):e1801054
Cholesterol Acceptors Regulate the Lipidome of Macrophage Foam Cells.
Paul A, Lydic TA, Hogan R, Goo YH
International journal of molecular sciences 2019 Aug 2;20(15)
International journal of molecular sciences 2019 Aug 2;20(15)
Prenatal Exposure to a Maternal High Fat Diet Increases Hepatic Cholesterol Accumulation in Intrauterine Growth Restricted Rats in Part Through MicroRNA-122 Inhibition of Cyp7a1.
Zinkhan EK, Yu B, Schlegel A
Frontiers in physiology 2018;9:645
Frontiers in physiology 2018;9:645
Liver X Receptor Agonist Therapy Prevents Diffuse Alveolar Hemorrhage in Murine Lupus by Repolarizing Macrophages.
Han S, Zhuang H, Shumyak S, Wu J, Xie C, Li H, Yang LJ, Reeves WH
Frontiers in immunology 2018;9:135
Frontiers in immunology 2018;9:135
Apolipoprotein A1 mimetic peptide ATI-5261 reverses arterial stiffness at late pregnancy and early postpartum in a COMT(-/-) mouse model of preeclampsia.
Liao S, Wu H, Chen R
Clinical hypertension 2018;24:11
Clinical hypertension 2018;24:11
Overexpression of Salusin-α Inhibits Vascular Intimal Hyperplasia in an Atherosclerotic Rabbit Model.
Qian K, Feng L, Sun Y, Xiong B, Ding Y, Han P, Chen H, Chen X, Du L, Wang Y
BioMed research international 2018;2018:8973986
BioMed research international 2018;2018:8973986
E3317 promotes cholesterol efflux in macrophage cells via enhancing ABCA1 expression.
Wang X, Luo J, Li N, Liu L, Han X, Liu C, Zuo X, Jiang X, Li Y, Xu Y, Si S
Biochemical and biophysical research communications 2018 Sep 26;504(1):68-74
Biochemical and biophysical research communications 2018 Sep 26;504(1):68-74
Directional ABCA1-mediated cholesterol efflux and apoB-lipoprotein secretion in the retinal pigment epithelium.
Lyssenko NN, Haider N, Picataggi A, Cipollari E, Jiao W, Phillips MC, Rader DJ, Chavali VRM
Journal of lipid research 2018 Oct;59(10):1927-1939
Journal of lipid research 2018 Oct;59(10):1927-1939
SREBF1/MicroRNA-33b Axis Exhibits Potent Effect on Unstable Atherosclerotic Plaque Formation In Vivo.
Nishino T, Horie T, Baba O, Sowa N, Hanada R, Kuwabara Y, Nakao T, Nishiga M, Nishi H, Nakashima Y, Nakazeki F, Ide Y, Koyama S, Kimura M, Nagata M, Yoshida K, Takagi Y, Nakamura T, Hasegawa K, Miyamoto S, Kimura T, Ono K
Arteriosclerosis, thrombosis, and vascular biology 2018 Oct;38(10):2460-2473
Arteriosclerosis, thrombosis, and vascular biology 2018 Oct;38(10):2460-2473
Positive association between cholesterol in human seminal plasma and sperm counts: results from a cross-sectional cohort study and immunohistochemical investigations.
de Neergaard R, Nielsen JE, Jørgensen A, Toft BG, Goetze JP, Jørgensen N
Andrology 2018 Nov;6(6):817-828
Andrology 2018 Nov;6(6):817-828
Dysregulation of cardiac lipid parameters in high-fat high-cholesterol diet-induced rat model.
Han Q, Yeung SC, Ip MSM, Mak JCW
Lipids in health and disease 2018 Nov 14;17(1):255
Lipids in health and disease 2018 Nov 14;17(1):255
Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA.
Sallam T, Jones M, Thomas BJ, Wu X, Gilliland T, Qian K, Eskin A, Casero D, Zhang Z, Sandhu J, Salisbury D, Rajbhandari P, Civelek M, Hong C, Ito A, Liu X, Daniel B, Lusis AJ, Whitelegge J, Nagy L, Castrillo A, Smale S, Tontonoz P
Nature medicine 2018 Mar;24(3):304-312
Nature medicine 2018 Mar;24(3):304-312
Active liver X receptor signaling in phagocytes in multiple sclerosis lesions.
Mailleux J, Vanmierlo T, Bogie JF, Wouters E, Lütjohann D, Hendriks JJ, van Horssen J
Multiple sclerosis (Houndmills, Basingstoke, England) 2018 Mar;24(3):279-289
Multiple sclerosis (Houndmills, Basingstoke, England) 2018 Mar;24(3):279-289
Ablating both Fabp1 and Scp2/Scpx (TKO) induces hepatic phospholipid and cholesterol accumulation in high fat-fed mice.
Milligan S, Martin GG, Landrock D, McIntosh AL, Mackie JT, Schroeder F, Kier AB
Biochimica et biophysica acta. Molecular and cell biology of lipids 2018 Mar;1863(3):323-338
Biochimica et biophysica acta. Molecular and cell biology of lipids 2018 Mar;1863(3):323-338
Adipose-Derived Exosomes Exert Proatherogenic Effects by Regulating Macrophage Foam Cell Formation and Polarization.
Xie Z, Wang X, Liu X, Du H, Sun C, Shao X, Tian J, Gu X, Wang H, Tian J, Yu B
Journal of the American Heart Association 2018 Mar 3;7(5)
Journal of the American Heart Association 2018 Mar 3;7(5)
A critical role for ABC transporters in persistent lung inflammation in the development of emphysema after smoke exposure.
Sonett J, Goldklang M, Sklepkiewicz P, Gerber A, Trischler J, Zelonina T, Westerterp M, Lemaître V, Okada Y, D'Armiento J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 15;:fj201701381
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 15;:fj201701381
6-Dihydroparadol, a Ginger Constituent, Enhances Cholesterol Efflux from THP-1-Derived Macrophages.
Wang D, Hiebl V, Ladurner A, Latkolik SL, Bucar F, Heiß EH, Dirsch VM, Atanasov AG
Molecular nutrition & food research 2018 Jul;62(14):e1800011
Molecular nutrition & food research 2018 Jul;62(14):e1800011
SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.
Feng T, Liu P, Wang X, Luo J, Zuo X, Jiang X, Liu C, Li Y, Li N, Chen M, Zhu N, Han X, Liu C, Xu Y, Si S
Atherosclerosis 2018 Jul;274:172-181
Atherosclerosis 2018 Jul;274:172-181
Novel interactomics approach identifies ABCA1 as direct target of evodiamine, which increases macrophage cholesterol efflux.
Wang L, Eftekhari P, Schachner D, Ignatova ID, Palme V, Schilcher N, Ladurner A, Heiss EH, Stangl H, Dirsch VM, Atanasov AG
Scientific reports 2018 Jul 23;8(1):11061
Scientific reports 2018 Jul 23;8(1):11061
Toll-like receptor 2 downregulates the cholesterol efflux by activating the nuclear factor-κB pathway in macrophages and may be a potential therapeutic target for the prevention of atherosclerosis.
Li Y, Shen S, Ding S, Wang L
Experimental and therapeutic medicine 2018 Jan;15(1):198-204
Experimental and therapeutic medicine 2018 Jan;15(1):198-204
Cholesterol metabolism and Cx43, Cx46, and Cx50 gap junction protein expression and localization in normal and diabetic and obese ob/ob and db/db mouse testes.
Pelletier RM, Akpovi CD, Chen L, Vitale ML
American journal of physiology. Endocrinology and metabolism 2018 Jan 1;314(1):E21-E38
American journal of physiology. Endocrinology and metabolism 2018 Jan 1;314(1):E21-E38
Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function.
Li Z, Kabir I, Tietelman G, Huan C, Fan J, Worgall T, Jiang XC
Cell death & disease 2018 Feb 7;9(2):173
Cell death & disease 2018 Feb 7;9(2):173
Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer's disease.
Casali BT, Reed-Geaghan EG, Landreth GE
Journal of neuroinflammation 2018 Feb 15;15(1):43
Journal of neuroinflammation 2018 Feb 15;15(1):43
Elastic aortic wrap reduced aortic stiffness by partially alleviating the impairment of cholesterol efflux capacity in pigs.
Liao S, Zhou Q, Zhang Y
Journal of diabetes and metabolic disorders 2018 Dec;17(2):101-109
Journal of diabetes and metabolic disorders 2018 Dec;17(2):101-109
High-density lipoprotein mimetic peptide 4F mitigates amyloid-β-induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia.
Chernick D, Ortiz-Valle S, Jeong A, Swaminathan SK, Kandimalla KK, Rebeck GW, Li L
Journal of neurochemistry 2018 Dec;147(5):647-662
Journal of neurochemistry 2018 Dec;147(5):647-662
Homocysteine accelerates atherosclerosis via inhibiting LXRα-mediated ABCA1/ABCG1-dependent cholesterol efflux from macrophages.
Jin P, Bian Y, Wang K, Cong G, Yan R, Sha Y, Ma X, Zhou J, Yuan Z, Jia S
Life sciences 2018 Dec 1;214:41-50
Life sciences 2018 Dec 1;214:41-50
Temporary sequestration of cholesterol and phosphatidylcholine within extracellular domains of ABCA1 during nascent HDL generation.
Ishigami M, Ogasawara F, Nagao K, Hashimoto H, Kimura Y, Kioka N, Ueda K
Scientific reports 2018 Apr 18;8(1):6170
Scientific reports 2018 Apr 18;8(1):6170
Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells Attenuate Cigarette Smoke-Induced Cardiac Remodeling and Dysfunction.
Liang Y, Li X, Zhang Y, Yeung SC, Zhen Z, Ip MSM, Tse HF, Lian Q, Mak JCW
Frontiers in pharmacology 2017;8:501
Frontiers in pharmacology 2017;8:501
Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene.
Cook EC, Nelson JK, Sorrentino V, Koenis D, Moeton M, Scheij S, Ottenhoff R, Bleijlevens B, Loregger A, Zelcer N
PloS one 2017;12(2):e0172721
PloS one 2017;12(2):e0172721
NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis.
Widenmaier SB, Snyder NA, Nguyen TB, Arduini A, Lee GY, Arruda AP, Saksi J, Bartelt A, Hotamisligil GS
Cell 2017 Nov 16;171(5):1094-1109.e15
Cell 2017 Nov 16;171(5):1094-1109.e15
CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis.
Doran AC, Ozcan L, Cai B, Zheng Z, Fredman G, Rymond CC, Dorweiler B, Sluimer JC, Hsieh J, Kuriakose G, Tall AR, Tabas I
The Journal of clinical investigation 2017 Nov 1;127(11):4075-4089
The Journal of clinical investigation 2017 Nov 1;127(11):4075-4089
The lipid moiety 7-ketocholesteryl-9-carboxynonanoate mediates binding interaction of oxLDL to LOX-1 and upregulates ABCA1 expression through PPARγ.
Li J, Xiu Z, Wang R, Yu C, Chi Y, Qin J, Fu C, Matsuura E, Liu Q
Life sciences 2017 May 15;177:27-40
Life sciences 2017 May 15;177:27-40
MicroRNA-33 Controls Adaptive Fibrotic Response in the Remodeling Heart by Preserving Lipid Raft Cholesterol.
Nishiga M, Horie T, Kuwabara Y, Nagao K, Baba O, Nakao T, Nishino T, Hakuno D, Nakashima Y, Nishi H, Nakazeki F, Ide Y, Koyama S, Kimura M, Hanada R, Nakamura T, Inada T, Hasegawa K, Conway SJ, Kita T, Kimura T, Ono K
Circulation research 2017 Mar 3;120(5):835-847
Circulation research 2017 Mar 3;120(5):835-847
Heat shock protein 27-derived atheroprotection involves reverse cholesterol transport that is dependent on GM-CSF to maintain ABCA1 and ABCG1 expression in ApoE-/- mice.
Pulakazhi Venu VK, Adijiang A, Seibert T, Chen YX, Shi C, Batulan Z, O'Brien ER
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Jun;31(6):2364-2379
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Jun;31(6):2364-2379
Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway.
Morizawa YM, Hirayama Y, Ohno N, Shibata S, Shigetomi E, Sui Y, Nabekura J, Sato K, Okajima F, Takebayashi H, Okano H, Koizumi S
Nature communications 2017 Jun 22;8(1):28
Nature communications 2017 Jun 22;8(1):28
Activation of PPARγ does not contribute to macrophage ABCA1 expression and ABCA1-mediated cholesterol efflux to apoAI.
Jiang M, Li X
Biochemical and biophysical research communications 2017 Jan 22;482(4):849-856
Biochemical and biophysical research communications 2017 Jan 22;482(4):849-856
ATP binding cassette A1 (ABCA1) mediates microparticle formation during high-density lipoprotein (HDL) biogenesis.
Hafiane A, Genest J
Atherosclerosis 2017 Feb;257:90-99
Atherosclerosis 2017 Feb;257:90-99
Hawthorn (Crataegus pinnatifida Bunge) leave flavonoids attenuate atherosclerosis development in apoE knock-out mice.
Dong P, Pan L, Zhang X, Zhang W, Wang X, Jiang M, Chen Y, Duan Y, Wu H, Xu Y, Zhang P, Zhu Y
Journal of ethnopharmacology 2017 Feb 23;198:479-488
Journal of ethnopharmacology 2017 Feb 23;198:479-488
Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease.
Mariani MM, Malm T, Lamb R, Jay TR, Neilson L, Casali B, Medarametla L, Landreth GE
Scientific reports 2017 Feb 16;7:42270
Scientific reports 2017 Feb 16;7:42270
Regulated efflux of photoreceptor outer segment-derived cholesterol by human RPE cells.
Storti F, Raphael G, Griesser V, Klee K, Drawnel F, Willburger C, Scholz R, Langmann T, von Eckardstein A, Fingerle J, Grimm C, Maugeais C
Experimental eye research 2017 Dec;165:65-77
Experimental eye research 2017 Dec;165:65-77
Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP-1-derived macrophages.
Wang L, Palme V, Rotter S, Schilcher N, Cukaj M, Wang D, Ladurner A, Heiss EH, Stangl H, Dirsch VM, Atanasov AG
Molecular nutrition & food research 2017 Apr;61(4)
Molecular nutrition & food research 2017 Apr;61(4)
Bilirubin Decreases Macrophage Cholesterol Efflux and ATP-Binding Cassette Transporter A1 Protein Expression.
Wang D, Tosevska A, Heiß EH, Ladurner A, Mölzer C, Wallner M, Bulmer A, Wagner KH, Dirsch VM, Atanasov AG
Journal of the American Heart Association 2017 Apr 28;6(5)
Journal of the American Heart Association 2017 Apr 28;6(5)
Cortistatin reduces atherosclerosis in hyperlipidemic ApoE-deficient mice and the formation of foam cells.
Delgado-Maroto V, Benitez R, Forte-Lago I, Morell M, Maganto-Garcia E, Souza-Moreira L, O'Valle F, Duran-Prado M, Lichtman AH, Gonzalez-Rey E, Delgado M
Scientific reports 2017 Apr 13;7:46444
Scientific reports 2017 Apr 13;7:46444
M1- and M2-Type Macrophage Responses Are Predictive of Adverse Outcomes in Human Atherosclerosis.
de Gaetano M, Crean D, Barry M, Belton O
Frontiers in immunology 2016;7:275
Frontiers in immunology 2016;7:275
Dietary high cholesterol and trace metals in the drinking water increase levels of ABCA1 in the rabbit hippocampus and temporal cortex.
Schreurs BG, Sparks DL
Journal of Alzheimer's disease : JAD 2016;49(1):201-9
Journal of Alzheimer's disease : JAD 2016;49(1):201-9
Ajwa Date (Phoenix dactylifera L.) Extract Inhibits Human Breast Adenocarcinoma (MCF7) Cells In Vitro by Inducing Apoptosis and Cell Cycle Arrest.
Khan F, Ahmed F, Pushparaj PN, Abuzenadah A, Kumosani T, Barbour E, AlQahtani M, Gauthaman K
PloS one 2016;11(7):e0158963
PloS one 2016;11(7):e0158963
Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins.
Cermak S, Kosicek M, Mladenovic-Djordjevic A, Smiljanic K, Kanazir S, Hecimovic S
PloS one 2016;11(11):e0167428
PloS one 2016;11(11):e0167428
AMPK activates LXRα and ABCA1 expression in human macrophages.
Kemmerer M, Wittig I, Richter F, Brüne B, Namgaladze D
The international journal of biochemistry & cell biology 2016 Sep;78:1-9
The international journal of biochemistry & cell biology 2016 Sep;78:1-9
Quercetin stabilizes apolipoprotein E and reduces brain Aβ levels in amyloid model mice.
Zhang X, Hu J, Zhong L, Wang N, Yang L, Liu CC, Li H, Wang X, Zhou Y, Zhang Y, Xu H, Bu G, Zhuang J
Neuropharmacology 2016 Sep;108:179-92
Neuropharmacology 2016 Sep;108:179-92
MicroRNA-33 Regulates the Innate Immune Response via ATP Binding Cassette Transporter-mediated Remodeling of Membrane Microdomains.
Lai L, Azzam KM, Lin WC, Rai P, Lowe JM, Gabor KA, Madenspacher JH, Aloor JJ, Parks JS, Näär AM, Fessler MB
The Journal of biological chemistry 2016 Sep 9;291(37):19651-60
The Journal of biological chemistry 2016 Sep 9;291(37):19651-60
Triptolide inhibits the progression of atherosclerosis in apolipoprotein E(-)/(-) mice.
Luo L, Yang T
Experimental and therapeutic medicine 2016 Oct;12(4):2307-2313
Experimental and therapeutic medicine 2016 Oct;12(4):2307-2313
Inhibition of apolipoprotein B synthesis stimulates endoplasmic reticulum autophagy that prevents steatosis.
Conlon DM, Thomas T, Fedotova T, Hernandez-Ono A, Di Paolo G, Chan RB, Ruggles K, Gibeley S, Liu J, Ginsberg HN
The Journal of clinical investigation 2016 Oct 3;126(10):3852-3867
The Journal of clinical investigation 2016 Oct 3;126(10):3852-3867
Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages.
Shrestha E, Hussein MA, Savas JN, Ouimet M, Barrett TJ, Leone S, Yates JR 3rd, Moore KJ, Fisher EA, Garabedian MJ
The Journal of biological chemistry 2016 May 20;291(21):11172-84
The Journal of biological chemistry 2016 May 20;291(21):11172-84
Ursolic acid enhances macrophage autophagy and attenuates atherogenesis.
Leng S, Iwanowycz S, Saaoud F, Wang J, Wang Y, Sergin I, Razani B, Fan D
Journal of lipid research 2016 Jun;57(6):1006-16
Journal of lipid research 2016 Jun;57(6):1006-16
MiR-33a Decreases High-Density Lipoprotein-Induced Radiation Sensitivity in Breast Cancer.
Wolfe AR, Bambhroliya A, Reddy JP, Debeb BG, Huo L, Larson R, Li L, Ueno NT, Woodward WA
International journal of radiation oncology, biology, physics 2016 Jun 1;95(2):791-9
International journal of radiation oncology, biology, physics 2016 Jun 1;95(2):791-9
Smooth Muscle Cell Foam Cell Formation, Apolipoproteins, and ABCA1 in Intracranial Aneurysms: Implications for Lipid Accumulation as a Promoter of Aneurysm Wall Rupture.
Ollikainen E, Tulamo R, Lehti S, Lee-Rueckert M, Hernesniemi J, Niemelä M, Ylä-Herttuala S, Kovanen PT, Frösen J
Journal of neuropathology and experimental neurology 2016 Jul;75(7):689-99
Journal of neuropathology and experimental neurology 2016 Jul;75(7):689-99
Intrauterine growth restriction combined with a maternal high-fat diet increases hepatic cholesterol and low-density lipoprotein receptor activity in rats.
Zinkhan EK, Zalla JM, Carpenter JR, Yu B, Yu X, Chan G, Joss-Moore L, Lane RH
Physiological reports 2016 Jul;4(13)
Physiological reports 2016 Jul;4(13)
Allogeneic Mesenchymal Stromal Cells Overexpressing Mutant Human Hypoxia-Inducible Factor 1-α (HIF1-α) in an Ovine Model of Acute Myocardial Infarction.
Hnatiuk AP, Ong SG, Olea FD, Locatelli P, Riegler J, Lee WH, Jen CH, De Lorenzi A, Giménez CS, Laguens R, Wu JC, Crottogini A
Journal of the American Heart Association 2016 Jul 6;5(7)
Journal of the American Heart Association 2016 Jul 6;5(7)
9-cis β-Carotene Increased Cholesterol Efflux to HDL in Macrophages.
Bechor S, Zolberg Relevy N, Harari A, Almog T, Kamari Y, Ben-Amotz A, Harats D, Shaish A
Nutrients 2016 Jul 19;8(7)
Nutrients 2016 Jul 19;8(7)
TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis.
Hsieh J, Koseki M, Molusky MM, Yakushiji E, Ichi I, Westerterp M, Iqbal J, Chan RB, Abramowicz S, Tascau L, Takiguchi S, Yamashita S, Welch CL, Di Paolo G, Hussain MM, Lefkowitch JH, Rader DJ, Tall AR
Nature 2016 Jul 14;535(7611):303-7
Nature 2016 Jul 14;535(7611):303-7
Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophages.
Kim SY, Lim EJ, Yoon YS, Ahn YH, Park EM, Kim HS, Kang JL
Scientific reports 2016 Jul 13;6:29673
Scientific reports 2016 Jul 13;6:29673
Lanatoside C Promotes Foam Cell Formation and Atherosclerosis.
Shi H, Mao X, Zhong Y, Liu Y, Zhao X, Yu K, Zhu R, Wei Y, Zhu J, Sun H, Mao Y, Zeng Q
Scientific reports 2016 Jan 29;6:20154
Scientific reports 2016 Jan 29;6:20154
Difference in expression patterns of placental cholesterol transporters, ABCA1 and SR-BI, in Meishan and Yorkshire pigs with different placental efficiency.
Hong L, Xu X, Huang J, Lei M, Xu D, Zhao S, Yu M
Scientific reports 2016 Feb 8;6:20503
Scientific reports 2016 Feb 8;6:20503
miR-145 Regulates Diabetes-Bone Marrow Stromal Cell-Induced Neurorestorative Effects in Diabetes Stroke Rats.
Cui C, Ye X, Chopp M, Venkat P, Zacharek A, Yan T, Ning R, Yu P, Cui G, Chen J
Stem cells translational medicine 2016 Dec;5(12):1656-1667
Stem cells translational medicine 2016 Dec;5(12):1656-1667
Seminal Plasma Characteristics and Expression of ATP-binding Cassette Transporter A1 (ABCA1) in Canine Spermatozoa from Ejaculates with Good and Bad Freezability.
Schäfer-Somi S, Palme N
Reproduction in domestic animals = Zuchthygiene 2016 Apr;51(2):232-9
Reproduction in domestic animals = Zuchthygiene 2016 Apr;51(2):232-9
Eicosapentaenoic acid membrane incorporation impairs ABCA1-dependent cholesterol efflux via a protein kinase A signaling pathway in primary human macrophages.
Fournier N, Tardivel S, Benoist JF, Vedie B, Rousseau-Ralliard D, Nowak M, Allaoui F, Paul JL
Biochimica et biophysica acta 2016 Apr;1861(4):331-41
Biochimica et biophysica acta 2016 Apr;1861(4):331-41
The cholesterol transporter ABCA1 is expressed in stallion spermatozoa and reproductive tract tissues.
Merkl M, Ertl R, Handschuh S, Aurich C, Schäfer-Somi S
Theriogenology 2016 Apr 1;85(6):1080-9
Theriogenology 2016 Apr 1;85(6):1080-9
Hypermethylation of the TGF-β target, ABCA1 is associated with poor prognosis in ovarian cancer patients.
Chou JL, Huang RL, Shay J, Chen LY, Lin SJ, Yan PS, Chao WT, Lai YH, Lai YL, Chao TK, Lee CI, Tai CK, Wu SF, Nephew KP, Huang TH, Lai HC, Chan MW
Clinical epigenetics 2015;7(1):1
Clinical epigenetics 2015;7(1):1
LXR-Mediated ABCA1 Expression and Function Are Modulated by High Glucose and PRMT2.
Hussein MA, Shrestha E, Ouimet M, Barrett TJ, Leone S, Moore KJ, Hérault Y, Fisher EA, Garabedian MJ
PloS one 2015;10(8):e0135218
PloS one 2015;10(8):e0135218
Stimulation of Liver X Receptor Has Potent Anti-HIV Effects in a Humanized Mouse Model of HIV Infection.
Ramezani A, Dubrovsky L, Pushkarsky T, Sviridov D, Karandish S, Raj DS, Fitzgerald ML, Bukrinsky M
The Journal of pharmacology and experimental therapeutics 2015 Sep;354(3):376-83
The Journal of pharmacology and experimental therapeutics 2015 Sep;354(3):376-83
Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease.
Casali BT, Corona AW, Mariani MM, Karlo JC, Ghosal K, Landreth GE
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Jun 17;35(24):9173-81
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Jun 17;35(24):9173-81
Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells.
Baker AH, Watt J, Huang CK, Gerstenfeld LC, Schlezinger JJ
Chemical research in toxicology 2015 Jun 15;28(6):1156-66
Chemical research in toxicology 2015 Jun 15;28(6):1156-66
Enolase is regulated by Liver X Receptors.
De Boussac H, Maqdasy S, Trousson A, Zelcer N, Volle DH, Lobaccaro JM, Baron S
Steroids 2015 Jul;99(Pt B):266-71
Steroids 2015 Jul;99(Pt B):266-71
LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling.
Ito A, Hong C, Rong X, Zhu X, Tarling EJ, Hedde PN, Gratton E, Parks J, Tontonoz P
eLife 2015 Jul 14;4:e08009
eLife 2015 Jul 14;4:e08009
Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1.
Fond AM, Lee CS, Schulman IG, Kiss RS, Ravichandran KS
The Journal of clinical investigation 2015 Jul 1;125(7):2748-58
The Journal of clinical investigation 2015 Jul 1;125(7):2748-58
RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes.
Daffu G, Shen X, Senatus L, Thiagarajan D, Abedini A, Hurtado Del Pozo C, Rosario R, Song F, Friedman RA, Ramasamy R, Schmidt AM
Diabetes 2015 Dec;64(12):4046-60
Diabetes 2015 Dec;64(12):4046-60
Purple perilla extracts with α-asarone enhance cholesterol efflux from oxidized LDL-exposed macrophages.
Park SH, Paek JH, Shin D, Lee JY, Lim SS, Kang YH
International journal of molecular medicine 2015 Apr;35(4):957-65
International journal of molecular medicine 2015 Apr;35(4):957-65
Sparstolonin B suppresses rat vascular smooth muscle cell proliferation, migration, inflammatory response and lipid accumulation.
Liu Q, Li J, Liang Q, Wang D, Luo Y, Yu F, Janicki JS, Fan D
Vascular pharmacology 2015 Apr-Jun;67-69:59-66
Vascular pharmacology 2015 Apr-Jun;67-69:59-66
Up-regulation of the ATP-binding cassette transporter A1 inhibits hepatitis C virus infection.
Bocchetta S, Maillard P, Yamamoto M, Gondeau C, Douam F, Lebreton S, Lagaye S, Pol S, Helle F, Plengpanich W, Guérin M, Bourgine M, Michel ML, Lavillette D, Roingeard P, le Goff W, Budkowska A
PloS one 2014;9(3):e92140
PloS one 2014;9(3):e92140
Vasoprotective effects of urocortin 1 against atherosclerosis in vitro and in vivo.
Hasegawa A, Sato K, Shirai R, Watanabe R, Yamamoto K, Watanabe K, Nohtomi K, Hirano T, Watanabe T
PloS one 2014;9(12):e110866
PloS one 2014;9(12):e110866
Akt inhibition promotes ABCA1-mediated cholesterol efflux to ApoA-I through suppressing mTORC1.
Dong F, Mo Z, Eid W, Courtney KC, Zha X
PloS one 2014;9(11):e113789
PloS one 2014;9(11):e113789
Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo.
Tai LM, Koster KP, Luo J, Lee SH, Wang YT, Collins NC, Ben Aissa M, Thatcher GR, LaDu MJ
The Journal of biological chemistry 2014 Oct 31;289(44):30538-55
The Journal of biological chemistry 2014 Oct 31;289(44):30538-55
Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance.
Shibuya Y, Chang CC, Huang LH, Bryleva EY, Chang TY
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Oct 22;34(43):14484-501
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Oct 22;34(43):14484-501
The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice.
Hong C, Marshall SM, McDaniel AL, Graham M, Layne JD, Cai L, Scotti E, Boyadjian R, Kim J, Chamberlain BT, Tangirala RK, Jung ME, Fong L, Lee R, Young SG, Temel RE, Tontonoz P
Cell metabolism 2014 Nov 4;20(5):910-918
Cell metabolism 2014 Nov 4;20(5):910-918
Cubilin maintains blood levels of HDL and albumin.
Aseem O, Smith BT, Cooley MA, Wilkerson BA, Argraves KM, Remaley AT, Argraves WS
Journal of the American Society of Nephrology : JASN 2014 May;25(5):1028-36
Journal of the American Society of Nephrology : JASN 2014 May;25(5):1028-36
Fumigaclavine C activates PPARγ pathway and attenuates atherogenesis in ApoE-deficient mice.
Du RH, Qin SY, Shi LS, Zhou ZQ, Zhu XY, Liu J, Tan RX, Cao W
Atherosclerosis 2014 May;234(1):120-8
Atherosclerosis 2014 May;234(1):120-8
Pentraxin 3 promotes oxLDL uptake and inhibits cholesterol efflux from macrophage-derived foam cells.
Liu W, Jiang J, Yan D, Li D, Li W, Ma Y, Yang L, Qu Z, Ruan Q
Experimental and molecular pathology 2014 Jun;96(3):292-9
Experimental and molecular pathology 2014 Jun;96(3):292-9
The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis.
Sallam T, Ito A, Rong X, Kim J, van Stijn C, Chamberlain BT, Jung ME, Chao LC, Jones M, Gilliland T, Wu X, Su GL, Tangirala RK, Tontonoz P, Hong C
Journal of lipid research 2014 Jun;55(6):1120-30
Journal of lipid research 2014 Jun;55(6):1120-30
Immunolocalization of the cholesterol transporters ABCA1 and ABCG1 in canine reproductive tract tissues and spermatozoa.
Palme N, Becher AC, Merkl M, Glösmann M, Aurich C, Schäfer-Somi S
Reproduction in domestic animals = Zuchthygiene 2014 Jun;49(3):441-7
Reproduction in domestic animals = Zuchthygiene 2014 Jun;49(3):441-7
7-ketocholesteryl-9-carboxynonanoate enhances ATP binding cassette transporter A1 expression mediated by PPARγ in THP-1 macrophages.
Chi Y, Wang L, Liu Y, Ma Y, Wang R, Han X, Qiao H, Lin J, Matsuura E, Liu S, Liu Q
Atherosclerosis 2014 Jun;234(2):461-8
Atherosclerosis 2014 Jun;234(2):461-8
miR-206 controls LXRα expression and promotes LXR-mediated cholesterol efflux in macrophages.
Vinod M, Chennamsetty I, Colin S, Belloy L, De Paoli F, Schaider H, Graier WF, Frank S, Kratky D, Staels B, Chinetti-Gbaguidi G, Kostner GM
Biochimica et biophysica acta 2014 Jun;1841(6):827-35
Biochimica et biophysica acta 2014 Jun;1841(6):827-35
MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo.
Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Sowa N, Yahagi N, Shimano H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K
Scientific reports 2014 Jun 16;4:5312
Scientific reports 2014 Jun 16;4:5312
Expression of liver X receptor correlates with intrahepatic inflammation and fibrosis in patients with nonalcoholic fatty liver disease.
Ahn SB, Jang K, Jun DW, Lee BH, Shin KJ
Digestive diseases and sciences 2014 Dec;59(12):2975-82
Digestive diseases and sciences 2014 Dec;59(12):2975-82
Inhibition of atherosclerosis-promoting microRNAs via targeted polyelectrolyte complex micelles.
Kuo CH, Leon L, Chung EJ, Huang RT, Sontag TJ, Reardon CA, Getz GS, Tirrell M, Fang Y
Journal of materials chemistry. B 2014 Dec 14;2(46):8142-8153
Journal of materials chemistry. B 2014 Dec 14;2(46):8142-8153
Rutaecarpine suppresses atherosclerosis in ApoE-/- mice through upregulating ABCA1 and SR-BI within RCT.
Xu Y, Liu Q, Xu Y, Liu C, Wang X, He X, Zhu N, Liu J, Wu Y, Li Y, Li N, Feng T, Lai F, Zhang M, Hong B, Jiang JD, Si S
Journal of lipid research 2014 Aug;55(8):1634-47
Journal of lipid research 2014 Aug;55(8):1634-47
Identification of a selective agonist for liver X receptor α (LXRα) via screening of a synthetic compound library.
Li N, Xu Y, Feng T, Liu C, Li Y, Wang X, Si S
Journal of biomolecular screening 2014 Apr;19(4):566-74
Journal of biomolecular screening 2014 Apr;19(4):566-74
Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis.
Allahverdian S, Chehroudi AC, McManus BM, Abraham T, Francis GA
Circulation 2014 Apr 15;129(15):1551-9
Circulation 2014 Apr 15;129(15):1551-9
Inhibition of mitogen-activated protein kinase Erk1/2 promotes protein degradation of ATP binding cassette transporters A1 and G1 in CHO and HuH7 cells.
Mulay V, Wood P, Manetsch M, Darabi M, Cairns R, Hoque M, Chan KC, Reverter M, Alvarez-Guaita A, Rye KA, Rentero C, Heeren J, Enrich C, Grewal T
PloS one 2013;8(4):e62667
PloS one 2013;8(4):e62667
Lack of liver X receptors leads to cell proliferation in a model of mouse dorsal prostate epithelial cell.
Dufour J, Pommier A, Alves G, De Boussac H, Lours-Calet C, Volle DH, Lobaccaro JM, Baron S
PloS one 2013;8(3):e58876
PloS one 2013;8(3):e58876
Osbpl8 deficiency in mouse causes an elevation of high-density lipoproteins and gender-specific alterations of lipid metabolism.
Béaslas O, Metso J, Nissilä E, Laurila PP, Kaiharju E, Batchu KC, Kaipiainen L, Mäyränpää MI, Yan D, Gylling H, Jauhiainen M, Olkkonen VM
PloS one 2013;8(3):e58856
PloS one 2013;8(3):e58856
Bone marrow deficiency of MCPIP1 results in severe multi-organ inflammation but diminishes atherogenesis in hyperlipidemic mice.
Yu F, Du F, Wang Y, Huang S, Miao R, Major AS, Murphy EA, Fu M, Fan D
PloS one 2013;8(11):e80089
PloS one 2013;8(11):e80089
MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice.
Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Yahagi N, Shimano H, Matsumura S, Inoue K, Marusawa H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K
Nature communications 2013;4:2883
Nature communications 2013;4:2883
Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death.
Okabe A, Urano Y, Itoh S, Suda N, Kotani R, Nishimura Y, Saito Y, Noguchi N
Redox biology 2013;2:28-35
Redox biology 2013;2:28-35
ABC transporter activity linked to radiation resistance and molecular subtype in pediatric medulloblastoma.
Ingram WJ, Crowther LM, Little EB, Freeman R, Harliwong I, Veleva D, Hassall TE, Remke M, Taylor MD, Hallahan AR
Experimental hematology & oncology 2013 Oct 4;2(1):26
Experimental hematology & oncology 2013 Oct 4;2(1):26
Placental ABCA1 and ABCG1 expression in gestational disease: Pre-eclampsia affects ABCA1 levels in syncytiotrophoblasts.
Baumann M, Körner M, Huang X, Wenger F, Surbek D, Albrecht C
Placenta 2013 Nov;34(11):1079-86
Placenta 2013 Nov;34(11):1079-86
Quercetin-3-O-glucuronide induces ABCA1 expression by LXRα activation in murine macrophages.
Ohara K, Wakabayashi H, Taniguchi Y, Shindo K, Yajima H, Yoshida A
Biochemical and biophysical research communications 2013 Nov 29;441(4):929-34
Biochemical and biophysical research communications 2013 Nov 29;441(4):929-34
Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice.
Pommier AJ, Dufour J, Alves G, Viennois E, De Boussac H, Trousson A, Volle DH, Caira F, Val P, Arnaud P, Lobaccaro JM, Baron S
PLoS genetics 2013 May;9(5):e1003483
PLoS genetics 2013 May;9(5):e1003483
Lymphatic vessels are essential for the removal of cholesterol from peripheral tissues by SR-BI-mediated transport of HDL.
Lim HY, Thiam CH, Yeo KP, Bisoendial R, Hii CS, McGrath KC, Tan KW, Heather A, Alexander JS, Angeli V
Cell metabolism 2013 May 7;17(5):671-84
Cell metabolism 2013 May 7;17(5):671-84
DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism.
Zhang L, Jiang M, Shui Y, Chen Y, Wang Q, Hu W, Ma X, Li X, Liu X, Cao X, Liu M, Duan Y, Han J
Biochimica et biophysica acta 2013 Jun;1831(6):1134-45
Biochimica et biophysica acta 2013 Jun;1831(6):1134-45
Liver X receptors inhibit proliferation of human colorectal cancer cells and growth of intestinal tumors in mice.
Lo Sasso G, Bovenga F, Murzilli S, Salvatore L, Di Tullio G, Martelli N, D'Orazio A, Rainaldi S, Vacca M, Mangia A, Palasciano G, Moschetta A
Gastroenterology 2013 Jun;144(7):1497-507, 1507.e1-13
Gastroenterology 2013 Jun;144(7):1497-507, 1507.e1-13
MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor.
de Aguiar Vallim TQ, Tarling EJ, Kim T, Civelek M, Baldán Á, Esau C, Edwards PA
Circulation research 2013 Jun 7;112(12):1602-12
Circulation research 2013 Jun 7;112(12):1602-12
Factors controlling nascent high-density lipoprotein particle heterogeneity: ATP-binding cassette transporter A1 activity and cell lipid and apolipoprotein AI availability.
Lyssenko NN, Nickel M, Tang C, Phillips MC
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Jul;27(7):2880-92
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013 Jul;27(7):2880-92
Differential regulation of gene expression by LXRs in response to macrophage cholesterol loading.
Ignatova ID, Angdisen J, Moran E, Schulman IG
Molecular endocrinology (Baltimore, Md.) 2013 Jul;27(7):1036-47
Molecular endocrinology (Baltimore, Md.) 2013 Jul;27(7):1036-47
Knock-down of the oxysterol receptor LXRα impairs cholesterol efflux in human primary macrophages: lack of compensation by LXRβ activation.
Ishibashi M, Filomenko R, Rébé C, Chevriaux A, Varin A, Derangère V, Bessède G, Gambert P, Lagrost L, Masson D
Biochemical pharmacology 2013 Jul 1;86(1):122-9
Biochemical pharmacology 2013 Jul 1;86(1):122-9
Molecular mechanisms responsible for the reduced expression of cholesterol transporters from macrophages by low-dose endotoxin.
Maitra U, Li L
Arteriosclerosis, thrombosis, and vascular biology 2013 Jan;33(1):24-33
Arteriosclerosis, thrombosis, and vascular biology 2013 Jan;33(1):24-33
Advanced glycated albumin isolated from poorly controlled type 1 diabetes mellitus patients alters macrophage gene expression impairing ABCA-1-mediated reverse cholesterol transport.
Machado-Lima A, Iborra RT, Pinto RS, Sartori CH, Oliveira ER, Nakandakare ER, Stefano JT, Giannella-Neto D, Corrêa-Giannella ML, Passarelli M
Diabetes/metabolism research and reviews 2013 Jan;29(1):66-76
Diabetes/metabolism research and reviews 2013 Jan;29(1):66-76
TLR2 stimulates ABCA1 expression via PKC-η and PLD2 pathway.
Park DW, Lee HK, Lyu JH, Chin H, Kang SW, Kim YJ, Bae YS, Baek SH
Biochemical and biophysical research communications 2013 Jan 18;430(3):933-7
Biochemical and biophysical research communications 2013 Jan 18;430(3):933-7
Apelin-13 increases expression of ATP-binding cassette transporter A1 via activating protein kinase C α signaling in THP-1 macrophage-derived foam cells.
Liu XY, Lu Q, Ouyang XP, Tang SL, Zhao GJ, Lv YC, He PP, Kuang HJ, Tang YY, Fu Y, Zhang DW, Tang CK
Atherosclerosis 2013 Feb;226(2):398-407
Atherosclerosis 2013 Feb;226(2):398-407
Cholesterol efflux is differentially regulated in neurons and astrocytes: implications for brain cholesterol homeostasis.
Chen J, Zhang X, Kusumo H, Costa LG, Guizzetti M
Biochimica et biophysica acta 2013 Feb;1831(2):263-75
Biochimica et biophysica acta 2013 Feb;1831(2):263-75
Targeting GGTase-I activates RHOA, increases macrophage reverse cholesterol transport, and reduces atherosclerosis in mice.
Khan OM, Akula MK, Skålen K, Karlsson C, Ståhlman M, Young SG, Borén J, Bergo MO
Circulation 2013 Feb 19;127(7):782-90
Circulation 2013 Feb 19;127(7):782-90
Dysregulation of cholesterol homeostasis in human prostate cancer through loss of ABCA1.
Lee BH, Taylor MG, Robinet P, Smith JD, Schweitzer J, Sehayek E, Falzarano SM, Magi-Galluzzi C, Klein EA, Ting AH
Cancer research 2013 Feb 1;73(3):1211-8
Cancer research 2013 Feb 1;73(3):1211-8
The combination of L-4F and simvastatin stimulate cholesterol efflux and related proteins expressions to reduce atherosclerotic lesions in apoE knockout mice.
Ying R, Yuan Y, Qin YF, Tian D, Feng L, Guo ZG, Sun YX, Li MX
Lipids in health and disease 2013 Dec 8;12:180
Lipids in health and disease 2013 Dec 8;12:180
The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation.
Sorrentino V, Nelson JK, Maspero E, Marques ARA, Scheer L, Polo S, Zelcer N
Journal of lipid research 2013 Aug;54(8):2174-2184
Journal of lipid research 2013 Aug;54(8):2174-2184
Differential regulation of ABCA1 and macrophage cholesterol efflux by elaidic and oleic acids.
Shao F, Ford DA
Lipids 2013 Aug;48(8):757-67
Lipids 2013 Aug;48(8):757-67
The nuclear receptor LXRα controls the functional specialization of splenic macrophages.
A-Gonzalez N, Guillen JA, Gallardo G, Diaz M, de la Rosa JV, Hernandez IH, Casanova-Acebes M, Lopez F, Tabraue C, Beceiro S, Hong C, Lara PC, Andujar M, Arai S, Miyazaki T, Li S, Corbi AL, Tontonoz P, Hidalgo A, Castrillo A
Nature immunology 2013 Aug;14(8):831-9
Nature immunology 2013 Aug;14(8):831-9
Synthesis and identification of new flavonoids targeting liver X receptor β involved pathway as potential facilitators of Aβ clearance with reduced lipid accumulation.
Hu Y, Yang Y, Yu Y, Wen G, Shang N, Zhuang W, Lu D, Zhou B, Liang B, Yue X, Li F, Du J, Bu X
Journal of medicinal chemistry 2013 Aug 8;56(15):6033-53
Journal of medicinal chemistry 2013 Aug 8;56(15):6033-53
IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor.
Scotti E, Calamai M, Goulbourne CN, Zhang L, Hong C, Lin RR, Choi J, Pilch PF, Fong LG, Zou P, Ting AY, Pavone FS, Young SG, Tontonoz P
Molecular and cellular biology 2013 Apr;33(8):1503-14
Molecular and cellular biology 2013 Apr;33(8):1503-14
Intestine-specific Mttp deletion decreases mortality and prevents sepsis-induced intestinal injury in a murine model of Pseudomonas aeruginosa pneumonia.
Dominguez JA, Xie Y, Dunne WM, Yoseph BP, Burd EM, Coopersmith CM, Davidson NO
PloS one 2012;7(11):e49159
PloS one 2012;7(11):e49159
Efficacy of a therapeutic vaccine using mutated β-amyloid sensitized dendritic cells in Alzheimer's mice.
Luo Z, Li J, Nabar NR, Lin X, Bai G, Cai J, Zhou SF, Cao C, Wang J
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2012 Sep;7(3):640-55
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2012 Sep;7(3):640-55
miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity.
Allen RM, Marquart TJ, Albert CJ, Suchy FJ, Wang DQ, Ananthanarayanan M, Ford DA, Baldán A
EMBO molecular medicine 2012 Sep;4(9):882-95
EMBO molecular medicine 2012 Sep;4(9):882-95
Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2.
Noghero A, Perino A, Seano G, Saglio E, Lo Sasso G, Veglio F, Primo L, Hirsch E, Bussolino F, Morello F
Arteriosclerosis, thrombosis, and vascular biology 2012 Sep;32(9):2280-8
Arteriosclerosis, thrombosis, and vascular biology 2012 Sep;32(9):2280-8
Omega-6 polyunsaturated fatty acids prevent atherosclerosis development in LDLr-KO mice, in spite of displaying a pro-inflammatory profile similar to trans fatty acids.
Machado RM, Nakandakare ER, Quintao EC, Cazita PM, Koike MK, Nunes VS, Ferreira FD, Afonso MS, Bombo RP, Machado-Lima A, Soriano FG, Catanozi S, Lottenberg AM
Atherosclerosis 2012 Sep;224(1):66-74
Atherosclerosis 2012 Sep;224(1):66-74
Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype.
Cardilo-Reis L, Gruber S, Schreier SM, Drechsler M, Papac-Milicevic N, Weber C, Wagner O, Stangl H, Soehnlein O, Binder CJ
EMBO molecular medicine 2012 Oct;4(10):1072-86
EMBO molecular medicine 2012 Oct;4(10):1072-86
Host HDL biogenesis machinery is recruited to the inclusion of Chlamydia trachomatis-infected cells and regulates chlamydial growth.
Cox JV, Naher N, Abdelrahman YM, Belland RJ
Cellular microbiology 2012 Oct;14(10):1497-512
Cellular microbiology 2012 Oct;14(10):1497-512
Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis.
Zhou Q, Mei Y, Shoji T, Han X, Kaminski K, Oh GT, Ongusaha PP, Zhang K, Schmitt H, Moser M, Bode C, Liao JK
Circulation 2012 Oct 30;126(18):2236-47
Circulation 2012 Oct 30;126(18):2236-47
Modulation of lipid metabolism with the overexpression of NPC1L1 in mouse liver.
Kurano M, Hara M, Tsuneyama K, Okamoto K, Iso-O N, Matsushima T, Koike K, Tsukamoto K
Journal of lipid research 2012 Nov;53(11):2275-85
Journal of lipid research 2012 Nov;53(11):2275-85
Loss of liver FA binding protein significantly alters hepatocyte plasma membrane microdomains.
McIntosh AL, Atshaves BP, Storey SM, Landrock KK, Landrock D, Martin GG, Kier AB, Schroeder F
Journal of lipid research 2012 Mar;53(3):467-80
Journal of lipid research 2012 Mar;53(3):467-80
Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells.
ElAli A, Hermann DM
Brain pathology (Zurich, Switzerland) 2012 Mar;22(2):175-87
Brain pathology (Zurich, Switzerland) 2012 Mar;22(2):175-87
ABCA1-dependent mobilization of lysosomal cholesterol requires functional Niemann-Pick C2 but not Niemann-Pick C1 protein.
Boadu E, Nelson RC, Francis GA
Biochimica et biophysica acta 2012 Mar;1821(3):396-404
Biochimica et biophysica acta 2012 Mar;1821(3):396-404
Acyl-CoA synthetase 1 is required for oleate and linoleate mediated inhibition of cholesterol efflux through ATP-binding cassette transporter A1 in macrophages.
Kanter JE, Tang C, Oram JF, Bornfeldt KE
Biochimica et biophysica acta 2012 Mar;1821(3):358-64
Biochimica et biophysica acta 2012 Mar;1821(3):358-64
Phospholipase A(2)-modified low-density lipoprotein activates liver X receptor in human macrophages.
Morbitzer D, Namgaladze D, Brüne B
Cell biochemistry and biophysics 2012 Jun;63(2):143-9
Cell biochemistry and biophysics 2012 Jun;63(2):143-9
PAPP-A negatively regulates ABCA1, ABCG1 and SR-B1 expression by inhibiting LXRα through the IGF-I-mediated signaling pathway.
Tang SL, Chen WJ, Yin K, Zhao GJ, Mo ZC, Lv YC, Ouyang XP, Yu XH, Kuang HJ, Jiang ZS, Fu YC, Tang CK
Atherosclerosis 2012 Jun;222(2):344-54
Atherosclerosis 2012 Jun;222(2):344-54
ER stress is associated with reduced ABCA-1 protein levels in macrophages treated with advanced glycated albumin - reversal by a chemical chaperone.
Castilho G, Okuda LS, Pinto RS, Iborra RT, Nakandakare ER, Santos CX, Laurindo FR, Passarelli M
The international journal of biochemistry & cell biology 2012 Jul;44(7):1078-86
The international journal of biochemistry & cell biology 2012 Jul;44(7):1078-86
Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease.
Mandrekar-Colucci S, Karlo JC, Landreth GE
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Jul 25;32(30):10117-28
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Jul 25;32(30):10117-28
Loss of Niemann Pick type C proteins 1 and 2 greatly enhances HIV infectivity and is associated with accumulation of HIV Gag and cholesterol in late endosomes/lysosomes.
Coleman EM, Walker TN, Hildreth JE
Virology journal 2012 Jan 24;9:31
Virology journal 2012 Jan 24;9:31
Lipid-bound apolipoproteins in tyrosyl radical-oxidized HDL stabilize ABCA1 like lipid-free apolipoprotein A-I.
Hossain MA, Ngeth S, Chan T, Oda MN, Francis GA
BMC biochemistry 2012 Jan 16;13:1
BMC biochemistry 2012 Jan 16;13:1
Deleterious impact of elaidic fatty acid on ABCA1-mediated cholesterol efflux from mouse and human macrophages.
Fournier N, Attia N, Rousseau-Ralliard D, Vedie B, Destaillats F, Grynberg A, Paul JL
Biochimica et biophysica acta 2012 Feb;1821(2):303-12
Biochimica et biophysica acta 2012 Feb;1821(2):303-12
Liver X receptor β and peroxisome proliferator-activated receptor δ regulate cholesterol transport in murine cholangiocytes.
Xia X, Jung D, Webb P, Zhang A, Zhang B, Li L, Ayers SD, Gabbi C, Ueno Y, Gustafsson JÅ, Alpini G, Moore DD, Lesage GD
Hepatology (Baltimore, Md.) 2012 Dec;56(6):2288-96
Hepatology (Baltimore, Md.) 2012 Dec;56(6):2288-96
Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1.
Peter C, Waibel M, Keppeler H, Lehmann R, Xu G, Halama A, Adamski J, Schulze-Osthoff K, Wesselborg S, Lauber K
Autoimmunity 2012 Dec;45(8):568-73
Autoimmunity 2012 Dec;45(8):568-73
MicroRNA-33 deficiency reduces the progression of atherosclerotic plaque in ApoE-/- mice.
Horie T, Baba O, Kuwabara Y, Chujo Y, Watanabe S, Kinoshita M, Horiguchi M, Nakamura T, Chonabayashi K, Hishizawa M, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K
Journal of the American Heart Association 2012 Dec;1(6):e003376
Journal of the American Heart Association 2012 Dec;1(6):e003376
Mitochondrial DNA polymorphisms specifically modify cerebral β-amyloid proteostasis.
Scheffler K, Krohn M, Dunkelmann T, Stenzel J, Miroux B, Ibrahim S, von Bohlen Und Halbach O, Heinze HJ, Walker LC, Gsponer JA, Pahnke J
Acta neuropathologica 2012 Aug;124(2):199-208
Acta neuropathologica 2012 Aug;124(2):199-208
Effect of 6-O-α-maltosyl-β cyclodextrin and its cholesterol inclusion complex on cellular cholesterol levels and ABCA1 and ABCG1 expression in mouse mastocytoma P-815 cells.
Okada Y, Ueyama K, Nishikawa J, Semma M, Ichikawa A
Carbohydrate research 2012 Aug 1;357:68-74
Carbohydrate research 2012 Aug 1;357:68-74
HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux.
Cui HL, Grant A, Mukhamedova N, Pushkarsky T, Jennelle L, Dubrovsky L, Gaus K, Fitzgerald ML, Sviridov D, Bukrinsky M
Journal of lipid research 2012 Apr;53(4):696-708
Journal of lipid research 2012 Apr;53(4):696-708
Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action.
Zhang J, Kris-Etherton PM, Thompson JT, Hannon DB, Gillies PJ, Heuvel JP
The Journal of nutritional biochemistry 2012 Apr;23(4):400-9
The Journal of nutritional biochemistry 2012 Apr;23(4):400-9
Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages.
Iio A, Ohguchi K, Iinuma M, Nozawa Y, Ito M
Journal of natural products 2012 Apr 27;75(4):563-6
Journal of natural products 2012 Apr 27;75(4):563-6
Intracellular cholesterol-binding proteins enhance HDL-mediated cholesterol uptake in cultured primary mouse hepatocytes.
Storey SM, McIntosh AL, Huang H, Landrock KK, Martin GG, Landrock D, Payne HR, Atshaves BP, Kier AB, Schroeder F
American journal of physiology. Gastrointestinal and liver physiology 2012 Apr 15;302(8):G824-39
American journal of physiology. Gastrointestinal and liver physiology 2012 Apr 15;302(8):G824-39
Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux.
Le Lay S, Rodriguez M, Jessup W, Rentero C, Li Q, Cartland S, Grewal T, Gaus K
PloS one 2011;6(8):e23353
PloS one 2011;6(8):e23353
Mifepristone treatment results in differential regulation of glycerolipid biosynthesis in baby hamster kidney cells expressing a mifepristone-inducible ABCA1.
Hauff KD, Mitchell RW, Xu FY, Dembinski T, Mymin D, Zha X, Choy PC, Hatch GM
Lipids 2011 Sep;46(9):795-804
Lipids 2011 Sep;46(9):795-804
Retinoic acid isomers up-regulate ATP binding cassette A1 and G1 and cholesterol efflux in rat astrocytes: implications for their therapeutic and teratogenic effects.
Chen J, Costa LG, Guizzetti M
The Journal of pharmacology and experimental therapeutics 2011 Sep;338(3):870-8
The Journal of pharmacology and experimental therapeutics 2011 Sep;338(3):870-8
Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice.
Nagashima M, Watanabe T, Terasaki M, Tomoyasu M, Nohtomi K, Kim-Kaneyama J, Miyazaki A, Hirano T
Diabetologia 2011 Oct;54(10):2649-59
Diabetologia 2011 Oct;54(10):2649-59
ABCA1 increases extracellular ATP to mediate cholesterol efflux to ApoA-I.
Lee JY, Karwatsky J, Ma L, Zha X
American journal of physiology. Cell physiology 2011 Oct;301(4):C886-94
American journal of physiology. Cell physiology 2011 Oct;301(4):C886-94
Membrane microdomains modulate oligomeric ABCA1 function: impact on apoAI-mediated lipid removal and phosphatidylcholine biosynthesis.
Iatan I, Bailey D, Ruel I, Hafiane A, Campbell S, Krimbou L, Genest J
Journal of lipid research 2011 Nov;52(11):2043-55
Journal of lipid research 2011 Nov;52(11):2043-55
Mycophenolic acid induces ATP-binding cassette transporter A1 (ABCA1) expression through the PPARγ-LXRα-ABCA1 pathway.
Xu Y, Lai F, Xu Y, Wu Y, Liu Q, Li N, Wei Y, Feng T, Zheng Z, Jiang W, Yu L, Hong B, Si S
Biochemical and biophysical research communications 2011 Nov 4;414(4):779-82
Biochemical and biophysical research communications 2011 Nov 4;414(4):779-82
13-hydroxy linoleic acid increases expression of the cholesterol transporters ABCA1, ABCG1 and SR-BI and stimulates apoA-I-dependent cholesterol efflux in RAW264.7 macrophages.
Kämmerer I, Ringseis R, Biemann R, Wen G, Eder K
Lipids in health and disease 2011 Nov 30;10:222
Lipids in health and disease 2011 Nov 30;10:222
Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.
Terwel D, Steffensen KR, Verghese PB, Kummer MP, Gustafsson JÅ, Holtzman DM, Heneka MT
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 May 11;31(19):7049-59
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 May 11;31(19):7049-59
Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target.
Hong C, Walczak R, Dhamko H, Bradley MN, Marathe C, Boyadjian R, Salazar JV, Tontonoz P
Journal of lipid research 2011 Mar;52(3):531-9
Journal of lipid research 2011 Mar;52(3):531-9
Expression and localization pattern of ABCA1 in diverse human placental primary cells and tissues.
Nikitina L, Wenger F, Baumann M, Surbek D, Körner M, Albrecht C
Placenta 2011 Jun;32(6):420-30
Placenta 2011 Jun;32(6):420-30
Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cells.
Ting TC, Miyazaki-Anzai S, Masuda M, Levi M, Demer LL, Tintut Y, Miyazaki M
The Journal of biological chemistry 2011 Jul 8;286(27):23938-49
The Journal of biological chemistry 2011 Jul 8;286(27):23938-49
Modulation of ABCA1 by an LXR agonist reduces β-amyloid levels and improves outcome after traumatic brain injury.
Loane DJ, Washington PM, Vardanian L, Pocivavsek A, Hoe HS, Duff KE, Cernak I, Rebeck GW, Faden AI, Burns MP
Journal of neurotrauma 2011 Feb;28(2):225-36
Journal of neurotrauma 2011 Feb;28(2):225-36
Ht31, a protein kinase A anchoring inhibitor, induces robust cholesterol efflux and reverses macrophage foam cell formation through ATP-binding cassette transporter A1.
Ma L, Dong F, Denis M, Feng Y, Wang MD, Zha X
The Journal of biological chemistry 2011 Feb 4;286(5):3370-8
The Journal of biological chemistry 2011 Feb 4;286(5):3370-8
Modulation of macrophage fatty acid content and composition by exposure to dyslipidemic serum in vitro.
Wong BX, Kyle RA, Croft KD, Quinn CM, Jessup W, Yeap BB
Lipids 2011 Apr;46(4):371-80
Lipids 2011 Apr;46(4):371-80
ABCA1 promotes the efflux of bacterial LPS from macrophages and accelerates recovery from LPS-induced tolerance.
Thompson PA, Gauthier KC, Varley AW, Kitchens RL
Journal of lipid research 2010 Sep;51(9):2672-85
Journal of lipid research 2010 Sep;51(9):2672-85
Placental ABCA1 and ABCG1 transporters efflux cholesterol and protect trophoblasts from oxysterol induced toxicity.
Aye IL, Waddell BJ, Mark PJ, Keelan JA
Biochimica et biophysica acta 2010 Sep;1801(9):1013-24
Biochimica et biophysica acta 2010 Sep;1801(9):1013-24
HAATI survivors replace canonical telomeres with blocks of generic heterochromatin.
Jain D, Hebden AK, Nakamura TM, Miller KM, Cooper JP
Nature 2010 Sep 9;467(7312):223-7
Nature 2010 Sep 9;467(7312):223-7
Characterization of apoA-I-dependent lipid efflux from adipocytes and role of ABCA1.
Howard AD, Verghese PB, Arrese EL, Soulages JL
Molecular and cellular biochemistry 2010 Oct;343(1-2):115-24
Molecular and cellular biochemistry 2010 Oct;343(1-2):115-24
The structural basis for membrane binding and pore formation by lymphocyte perforin.
Law RH, Lukoyanova N, Voskoboinik I, Caradoc-Davies TT, Baran K, Dunstone MA, D'Angelo ME, Orlova EV, Coulibaly F, Verschoor S, Browne KA, Ciccone A, Kuiper MJ, Bird PI, Trapani JA, Saibil HR, Whisstock JC
Nature 2010 Nov 18;468(7322):447-51
Nature 2010 Nov 18;468(7322):447-51
The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro.
McLaren JE, Calder CJ, McSharry BP, Sexton K, Salter RC, Singh NN, Wilkinson GW, Wang EC, Ramji DP
Journal of immunology (Baltimore, Md. : 1950) 2010 May 15;184(10):5827-34
Journal of immunology (Baltimore, Md. : 1950) 2010 May 15;184(10):5827-34
IL-33 reduces macrophage foam cell formation.
McLaren JE, Michael DR, Salter RC, Ashlin TG, Calder CJ, Miller AM, Liew FY, Ramji DP
Journal of immunology (Baltimore, Md. : 1950) 2010 Jul 15;185(2):1222-9
Journal of immunology (Baltimore, Md. : 1950) 2010 Jul 15;185(2):1222-9
The reverse cholesterol transport system as a potential mediator of luteolysis in the primate corpus luteum.
Bogan RL, Hennebold JD
Reproduction (Cambridge, England) 2010 Jan;139(1):163-76
Reproduction (Cambridge, England) 2010 Jan;139(1):163-76
Liver X receptor agonist inhibits proliferation of ovarian carcinoma cells stimulated by oxidized low density lipoprotein.
Scoles DR, Xu X, Wang H, Tran H, Taylor-Harding B, Li A, Karlan BY
Gynecologic oncology 2010 Jan;116(1):109-16
Gynecologic oncology 2010 Jan;116(1):109-16
Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia.
Zhang Y, Yin L, Anderson J, Ma H, Gonzalez FJ, Willson TM, Edwards PA
The Journal of biological chemistry 2010 Jan 29;285(5):3035-43
The Journal of biological chemistry 2010 Jan 29;285(5):3035-43
The liver-selective thyromimetic T-0681 influences reverse cholesterol transport and atherosclerosis development in mice.
Tancevski I, Demetz E, Eller P, Duwensee K, Hoefer J, Heim C, Stanzl U, Wehinger A, Auer K, Karer R, Huber J, Schgoer W, Van Eck M, Vanhoutte J, Fievet C, Stellaard F, Rudling M, Patsch JR, Ritsch A
PloS one 2010 Jan 15;5(1):e8722
PloS one 2010 Jan 15;5(1):e8722
Liver X receptor agonist treatment reduced splanchnic ischemia and reperfusion injury.
Crisafulli C, Di Paola R, Mazzon E, Paterniti I, Galuppo M, Genovese T, Bramanti P, Cappellani A, Cuzzocrea S
Journal of leukocyte biology 2010 Feb;87(2):309-21
Journal of leukocyte biology 2010 Feb;87(2):309-21
Enhanced aortic macrophage lipid accumulation and inflammatory response in LDL receptor null mice fed an atherogenic diet.
Wang S, Wu D, Matthan NR, Lamon-Fava S, Lecker JL, Lichtenstein AH
Lipids 2010 Aug;45(8):701-11
Lipids 2010 Aug;45(8):701-11
SR-BI, CD36, and caveolin-1 contribute positively to cholesterol efflux in hepatic cells.
Truong TQ, Aubin D, Falstrault L, Brodeur MR, Brissette L
Cell biochemistry and function 2010 Aug;28(6):480-9
Cell biochemistry and function 2010 Aug;28(6):480-9
Vitamin A deficiency results in dysregulation of lipid efflux pathway in rat kidney.
Yang H, Chen K, Zhang X, Wang L, Li C, Tao H, Wang L, Li Q
Pediatric nephrology (Berlin, Germany) 2010 Aug;25(8):1435-44
Pediatric nephrology (Berlin, Germany) 2010 Aug;25(8):1435-44
High glucose promotes intracellular lipid accumulation in vascular smooth muscle cells by impairing cholesterol influx and efflux balance.
Xue JH, Yuan Z, Wu Y, Liu Y, Zhao Y, Zhang WP, Tian YL, Liu WM, Liu Y, Kishimoto C
Cardiovascular research 2010 Apr 1;86(1):141-50
Cardiovascular research 2010 Apr 1;86(1):141-50
LXR regulate cholesterol homeostasis in the proximal mouse epididymis.
Ouvrier A, Cadet R, Lobaccaro JM, Drevet JR, Saez F
Folia histochemica et cytobiologica 2009;47(5):S75-9
Folia histochemica et cytobiologica 2009;47(5):S75-9
LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner.
Ouvrier A, Cadet R, Vernet P, Laillet B, Chardigny JM, Lobaccaro JM, Drevet JR, Saez F
Journal of lipid research 2009 Sep;50(9):1766-75
Journal of lipid research 2009 Sep;50(9):1766-75
A novel missense mutation of ABCA1 in transmembrane alpha-helix in a Japanese patient with Tangier disease.
Maekawa M, Kikuchi J, Kotani K, Nagao K, Odgerel T, Ueda K, Kawano M, Furukawa Y, Sakurabayashi I
Atherosclerosis 2009 Sep;206(1):216-22
Atherosclerosis 2009 Sep;206(1):216-22
Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2.
Welch C, Santra MK, El-Assaad W, Zhu X, Huber WE, Keys RA, Teodoro JG, Green MR
Cancer research 2009 Sep 1;69(17):6782-9
Cancer research 2009 Sep 1;69(17):6782-9
An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2.
Maitra U, Parks JS, Li L
Molecular and cellular biology 2009 Nov;29(22):5989-97
Molecular and cellular biology 2009 Nov;29(22):5989-97
The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor.
Tang C, Liu Y, Kessler PS, Vaughan AM, Oram JF
The Journal of biological chemistry 2009 Nov 20;284(47):32336-43
The Journal of biological chemistry 2009 Nov 20;284(47):32336-43
ABCA1-mediated cholesterol efflux generates microparticles in addition to HDL through processes governed by membrane rigidity.
Nandi S, Ma L, Denis M, Karwatsky J, Li Z, Jiang XC, Zha X
Journal of lipid research 2009 Mar;50(3):456-66
Journal of lipid research 2009 Mar;50(3):456-66
Defects in the regulatory clearance mechanisms favor the breakdown of self-tolerance during spontaneous autoimmune orchitis.
Pelletier RM, Yoon SR, Akpovi CD, Silvas E, Vitale ML
American journal of physiology. Regulatory, integrative and comparative physiology 2009 Mar;296(3):R743-62
American journal of physiology. Regulatory, integrative and comparative physiology 2009 Mar;296(3):R743-62
Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile.
Dang H, Liu Y, Pang W, Li C, Wang N, Shyy JY, Zhu Y
The Journal of biological chemistry 2009 Mar 6;284(10):6218-26
The Journal of biological chemistry 2009 Mar 6;284(10):6218-26
Renal mass reduction results in accumulation of lipids and dysregulation of lipid regulatory proteins in the remnant kidney.
Kim HJ, Moradi H, Yuan J, Norris K, Vaziri ND
American journal of physiology. Renal physiology 2009 Jun;296(6):F1297-306
American journal of physiology. Renal physiology 2009 Jun;296(6):F1297-306
Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in mice.
Liu J, Huan C, Chakraborty M, Zhang H, Lu D, Kuo MS, Cao G, Jiang XC
Circulation research 2009 Jul 31;105(3):295-303
Circulation research 2009 Jul 31;105(3):295-303
Serum, but not monocyte macrophage foam cells derived from low HDL-C subjects, displays reduced cholesterol efflux capacity.
Nakanishi S, Vikstedt R, Söderlund S, Lee-Rueckert M, Hiukka A, Ehnholm C, Muilu M, Metso J, Naukkarinen J, Palotie L, Kovanen PT, Jauhiainen M, Taskinen MR
Journal of lipid research 2009 Feb;50(2):183-92
Journal of lipid research 2009 Feb;50(2):183-92
Expression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium.
Duncan KG, Hosseini K, Bailey KR, Yang H, Lowe RJ, Matthes MT, Kane JP, LaVail MM, Schwartz DM, Duncan JL
The British journal of ophthalmology 2009 Aug;93(8):1116-20
The British journal of ophthalmology 2009 Aug;93(8):1116-20
Leptin modulates ACAT1 expression and cholesterol efflux from human macrophages.
Hongo S, Watanabe T, Arita S, Kanome T, Kageyama H, Shioda S, Miyazaki A
American journal of physiology. Endocrinology and metabolism 2009 Aug;297(2):E474-82
American journal of physiology. Endocrinology and metabolism 2009 Aug;297(2):E474-82
Insulin stimulates the expression of carbohydrate response element binding protein (ChREBP) by attenuating the repressive effect of Pit-1, Oct-1/Oct-2, and Unc-86 homeodomain protein octamer transcription factor-1.
Sirek AS, Liu L, Naples M, Adeli K, Ng DS, Jin T
Endocrinology 2009 Aug;150(8):3483-92
Endocrinology 2009 Aug;150(8):3483-92
Dietary soy protein isolate attenuates metabolic syndrome in rats via effects on PPAR, LXR, and SREBP signaling.
Ronis MJ, Chen Y, Badeaux J, Badger TM
The Journal of nutrition 2009 Aug;139(8):1431-8
The Journal of nutrition 2009 Aug;139(8):1431-8
In vitro fatty acid enrichment of macrophages alters inflammatory response and net cholesterol accumulation.
Wang S, Wu D, Lamon-Fava S, Matthan NR, Honda KL, Lichtenstein AH
The British journal of nutrition 2009 Aug;102(4):497-501
The British journal of nutrition 2009 Aug;102(4):497-501
Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis.
Xu G, Watanabe T, Iso Y, Koba S, Sakai T, Nagashima M, Arita S, Hongo S, Ota H, Kobayashi Y, Miyazaki A, Hirano T
Circulation research 2009 Aug 28;105(5):500-10
Circulation research 2009 Aug 28;105(5):500-10
CD36-mediated cholesterol efflux is associated with PPARgamma activation via a MAPK-dependent COX-2 pathway in macrophages.
Bujold K, Rhainds D, Jossart C, Febbraio M, Marleau S, Ong H
Cardiovascular research 2009 Aug 1;83(3):457-64
Cardiovascular research 2009 Aug 1;83(3):457-64
Thieno[2,3-c]isoquinolin-5-one, a potent poly(ADP-ribose) polymerase inhibitor, promotes atherosclerotic plaque regression in high-fat diet-fed apolipoprotein E-deficient mice: effects on inflammatory markers and lipid content.
Hans CP, Zerfaoui M, Naura AS, Troxclair D, Strong JP, Matrougui K, Boulares AH
The Journal of pharmacology and experimental therapeutics 2009 Apr;329(1):150-8
The Journal of pharmacology and experimental therapeutics 2009 Apr;329(1):150-8
Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis.
Bhatnagar S, Damron HA, Hillgartner FB
The Journal of biological chemistry 2009 Apr 10;284(15):10023-33
The Journal of biological chemistry 2009 Apr 10;284(15):10023-33
Cortical injury increases cholesterol 24S hydroxylase (Cyp46) levels in the rat brain.
Cartagena CM, Ahmed F, Burns MP, Pajoohesh-Ganji A, Pak DT, Faden AI, Rebeck GW
Journal of neurotrauma 2008 Sep;25(9):1087-98
Journal of neurotrauma 2008 Sep;25(9):1087-98
A novel enzyme immunoassay specific for ABCA1 protein quantification in human tissues and cells.
Paul V, Meyer HH, Leidl K, Soumian S, Albrecht C
Journal of lipid research 2008 Oct;49(10):2259-67
Journal of lipid research 2008 Oct;49(10):2259-67
Enhancing apolipoprotein A-I-dependent cholesterol efflux elevates cholesterol export from macrophages in vivo.
Mukhamedova N, Escher G, D'Souza W, Tchoua U, Grant A, Krozowski Z, Bukrinsky M, Sviridov D
Journal of lipid research 2008 Nov;49(11):2312-22
Journal of lipid research 2008 Nov;49(11):2312-22
Antiatherosclerotic effects of a novel synthetic tissue-selective steroidal liver X receptor agonist in low-density lipoprotein receptor-deficient mice.
Peng D, Hiipakka RA, Dai Q, Guo J, Reardon CA, Getz GS, Liao S
The Journal of pharmacology and experimental therapeutics 2008 Nov;327(2):332-42
The Journal of pharmacology and experimental therapeutics 2008 Nov;327(2):332-42
LXR-induced reverse cholesterol transport in human airway smooth muscle is mediated exclusively by ABCA1.
Delvecchio CJ, Bilan P, Nair P, Capone JP
American journal of physiology. Lung cellular and molecular physiology 2008 Nov;295(5):L949-57
American journal of physiology. Lung cellular and molecular physiology 2008 Nov;295(5):L949-57
Intestinal fatty acid binding protein regulates mitochondrion beta-oxidation and cholesterol uptake.
Montoudis A, Seidman E, Boudreau F, Beaulieu JF, Menard D, Elchebly M, Mailhot G, Sane AT, Lambert M, Delvin E, Levy E
Journal of lipid research 2008 May;49(5):961-72
Journal of lipid research 2008 May;49(5):961-72
alpha-Tocopherol disturbs macrophage LXRalpha regulation of ABCA1/G1 and cholesterol handling.
Rode S, Rubic T, Lorenz RL
Biochemical and biophysical research communications 2008 May 9;369(3):868-72
Biochemical and biophysical research communications 2008 May 9;369(3):868-72
Interferon-gamma reduces cell surface expression of annexin 2 and suppresses the invasive capacity of prostate cancer cells.
Hastie C, Masters JR, Moss SE, Naaby-Hansen S
The Journal of biological chemistry 2008 May 2;283(18):12595-603
The Journal of biological chemistry 2008 May 2;283(18):12595-603
Expression and biological activity of ABCA1 in alveolar epithelial cells.
Bates SR, Tao JQ, Yu KJ, Borok Z, Crandall ED, Collins HL, Rothblat GH
American journal of respiratory cell and molecular biology 2008 Mar;38(3):283-92
American journal of respiratory cell and molecular biology 2008 Mar;38(3):283-92
Laminar shear stress regulates liver X receptor in vascular endothelial cells.
Zhu M, Fu Y, Hou Y, Wang N, Guan Y, Tang C, Shyy JY, Zhu Y
Arteriosclerosis, thrombosis, and vascular biology 2008 Mar;28(3):527-33
Arteriosclerosis, thrombosis, and vascular biology 2008 Mar;28(3):527-33
Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense.
Smoak K, Madenspacher J, Jeyaseelan S, Williams B, Dixon D, Poch KR, Nick JA, Worthen GS, Fessler MB
Journal of immunology (Baltimore, Md. : 1950) 2008 Mar 1;180(5):3305-12
Journal of immunology (Baltimore, Md. : 1950) 2008 Mar 1;180(5):3305-12
Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense.
Smoak K, Madenspacher J, Jeyaseelan S, Williams B, Dixon D, Poch KR, Nick JA, Worthen GS, Fessler MB
Journal of immunology (Baltimore, Md. : 1950) 2008 Mar 1;180(5):3305-12
Journal of immunology (Baltimore, Md. : 1950) 2008 Mar 1;180(5):3305-12
Cholesterol transporter ATP-binding cassette A1 (ABCA1) is elevated in prion disease and affects PrPC and PrPSc concentrations in cultured cells.
Kumar R, McClain D, Young R, Carlson GA
The Journal of general virology 2008 Jun;89(Pt 6):1525-1532
The Journal of general virology 2008 Jun;89(Pt 6):1525-1532
Endoglin (CD105) expression is regulated by the liver X receptor alpha (NR1H3) in human trophoblast cell line JAR.
Henry-Berger J, Mouzat K, Baron S, Bernabeu C, Marceau G, Saru JP, Sapin V, Lobaccaro JM, Caira F
Biology of reproduction 2008 Jun;78(6):968-75
Biology of reproduction 2008 Jun;78(6):968-75
Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux.
Ouimet M, Wang MD, Cadotte N, Ho K, Marcel YL
Arteriosclerosis, thrombosis, and vascular biology 2008 Jun;28(6):1144-50
Arteriosclerosis, thrombosis, and vascular biology 2008 Jun;28(6):1144-50
OSBP negatively regulates ABCA1 protein stability.
Bowden K, Ridgway ND
The Journal of biological chemistry 2008 Jun 27;283(26):18210-7
The Journal of biological chemistry 2008 Jun 27;283(26):18210-7
Role of caveolin-1 in the regulation of lipoprotein metabolism.
Frank PG, Pavlides S, Cheung MW, Daumer K, Lisanti MP
American journal of physiology. Cell physiology 2008 Jul;295(1):C242-8
American journal of physiology. Cell physiology 2008 Jul;295(1):C242-8
Reduced plasma high-density lipoprotein cholesterol in hyperthyroid mice coincides with decreased hepatic adenosine 5'-triphosphate-binding cassette transporter 1 expression.
Tancevski I, Wehinger A, Demetz E, Eller P, Duwensee K, Huber J, Hochegger K, Schgoer W, Fievet C, Stellaard F, Rudling M, Patsch JR, Ritsch A
Endocrinology 2008 Jul;149(7):3708-12
Endocrinology 2008 Jul;149(7):3708-12
OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages.
Yan D, Mäyränpää MI, Wong J, Perttilä J, Lehto M, Jauhiainen M, Kovanen PT, Ehnholm C, Brown AJ, Olkkonen VM
The Journal of biological chemistry 2008 Jan 4;283(1):332-40
The Journal of biological chemistry 2008 Jan 4;283(1):332-40
Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1.
Out R, Jessup W, Le Goff W, Hoekstra M, Gelissen IC, Zhao Y, Kritharides L, Chimini G, Kuiper J, Chapman MJ, Huby T, Van Berkel TJ, Van Eck M
Circulation research 2008 Jan 4;102(1):113-20
Circulation research 2008 Jan 4;102(1):113-20
Hepatic CTP:phosphocholine cytidylyltransferase-alpha is a critical predictor of plasma high density lipoprotein and very low density lipoprotein.
Jacobs RL, Lingrell S, Zhao Y, Francis GA, Vance DE
The Journal of biological chemistry 2008 Jan 25;283(4):2147-55
The Journal of biological chemistry 2008 Jan 25;283(4):2147-55
Genetic deletion of low density lipoprotein receptor impairs sterol-induced mouse macrophage ABCA1 expression. A new SREBP1-dependent mechanism.
Zhou X, He W, Huang Z, Gotto AM Jr, Hajjar DP, Han J
The Journal of biological chemistry 2008 Jan 25;283(4):2129-38
The Journal of biological chemistry 2008 Jan 25;283(4):2129-38
Impact of salusin-alpha and -beta on human macrophage foam cell formation and coronary atherosclerosis.
Watanabe T, Nishio K, Kanome T, Matsuyama TA, Koba S, Sakai T, Sato K, Hongo S, Nose K, Ota H, Kobayashi Y, Katagiri T, Shichiri M, Miyazaki A
Circulation 2008 Feb 5;117(5):638-48
Circulation 2008 Feb 5;117(5):638-48
Ritonavir increases CD36, ABCA1 and CYP27 expression in THP-1 macrophages.
Pou J, Rebollo A, Roglans N, Sánchez RM, Vázquez-Carrera M, Laguna JC, Pedro-Botet J, Alegret M
Experimental biology and medicine (Maywood, N.J.) 2008 Dec;233(12):1572-82
Experimental biology and medicine (Maywood, N.J.) 2008 Dec;233(12):1572-82
A role for hepatic scavenger receptor class B, type I in decreasing high density lipoprotein levels in mice that lack phosphatidylethanolamine N-methyltransferase.
Robichaud JC, Francis GA, Vance DE
The Journal of biological chemistry 2008 Dec 19;283(51):35496-506
The Journal of biological chemistry 2008 Dec 19;283(51):35496-506
ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain.
Wang N, Yvan-Charvet L, Lütjohann D, Mulder M, Vanmierlo T, Kim TW, Tall AR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008 Apr;22(4):1073-82
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008 Apr;22(4):1073-82
Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.
Babaev VR, Ishiguro H, Ding L, Yancey PG, Dove DE, Kovacs WJ, Semenkovich CF, Fazio S, Linton MF
Circulation 2007 Sep 18;116(12):1404-12
Circulation 2007 Sep 18;116(12):1404-12
Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells.
During A, Harrison EH
Journal of lipid research 2007 Oct;48(10):2283-94
Journal of lipid research 2007 Oct;48(10):2283-94
SCP-2/SCP-x gene ablation alters lipid raft domains in primary cultured mouse hepatocytes.
Atshaves BP, McIntosh AL, Payne HR, Gallegos AM, Landrock K, Maeda N, Kier AB, Schroeder F
Journal of lipid research 2007 Oct;48(10):2193-211
Journal of lipid research 2007 Oct;48(10):2193-211
The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis.
Hoe HS, Cooper MJ, Burns MP, Lewis PA, van der Brug M, Chakraborty G, Cartagena CM, Pak DT, Cookson MR, Rebeck GW
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Oct 3;27(40):10895-905
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Oct 3;27(40):10895-905
Identification of an ABCA1-dependent phospholipid-rich plasma membrane apolipoprotein A-I binding site for nascent HDL formation: implications for current models of HDL biogenesis.
Hassan HH, Denis M, Lee DY, Iatan I, Nyholt D, Ruel I, Krimbou L, Genest J
Journal of lipid research 2007 Nov;48(11):2428-42
Journal of lipid research 2007 Nov;48(11):2428-42
Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors.
Zelcer N, Khanlou N, Clare R, Jiang Q, Reed-Geaghan EG, Landreth GE, Vinters HV, Tontonoz P
Proceedings of the National Academy of Sciences of the United States of America 2007 Jun 19;104(25):10601-6
Proceedings of the National Academy of Sciences of the United States of America 2007 Jun 19;104(25):10601-6
ABCA1, ABCG1 and SR-BI: hormonal regulation in primary rat hepatocytes and human cell lines.
Sporstøl M, Mousavi SA, Eskild W, Roos N, Berg T
BMC molecular biology 2007 Jan 22;8:5
BMC molecular biology 2007 Jan 22;8:5
Chenodeoxycholic acid suppresses the activation of acetyl-coenzyme A carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317.
Talukdar S, Bhatnagar S, Dridi S, Hillgartner FB
Journal of lipid research 2007 Dec;48(12):2647-63
Journal of lipid research 2007 Dec;48(12):2647-63
NO-1886 upregulates ATP binding cassette transporter A1 and inhibits diet-induced atherosclerosis in Chinese Bama minipigs.
Zhang C, Yin W, Liao D, Huang L, Tang C, Tsutsumi K, Wang Z, Liu Y, Li Q, Hou H, Cai M, Xiao J
Journal of lipid research 2006 Sep;47(9):2055-63
Journal of lipid research 2006 Sep;47(9):2055-63
Leukocyte transglutaminase 2 expression limits atherosclerotic lesion size.
Boisvert WA, Rose DM, Boullier A, Quehenberger O, Sydlaske A, Johnson KA, Curtiss LK, Terkeltaub R
Arteriosclerosis, thrombosis, and vascular biology 2006 Mar;26(3):563-9
Arteriosclerosis, thrombosis, and vascular biology 2006 Mar;26(3):563-9
Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice.
Trogan E, Feig JE, Dogan S, Rothblat GH, Angeli V, Tacke F, Randolph GJ, Fisher EA
Proceedings of the National Academy of Sciences of the United States of America 2006 Mar 7;103(10):3781-6
Proceedings of the National Academy of Sciences of the United States of America 2006 Mar 7;103(10):3781-6
Adenovirus-mediated overexpression of sphingomyelin synthases 1 and 2 increases the atherogenic potential in mice.
Dong J, Liu J, Lou B, Li Z, Ye X, Wu M, Jiang XC
Journal of lipid research 2006 Jun;47(6):1307-14
Journal of lipid research 2006 Jun;47(6):1307-14
IGF-1 induces rat glomerular mesangial cells to accumulate triglyceride.
Berfield AK, Chait A, Oram JF, Zager RA, Johnson AC, Abrass CK
American journal of physiology. Renal physiology 2006 Jan;290(1):F138-47
American journal of physiology. Renal physiology 2006 Jan;290(1):F138-47
TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells.
Gerbod-Giannone MC, Li Y, Holleboom A, Han S, Hsu LC, Tabas I, Tall AR
Proceedings of the National Academy of Sciences of the United States of America 2006 Feb 28;103(9):3112-7
Proceedings of the National Academy of Sciences of the United States of America 2006 Feb 28;103(9):3112-7
Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I.
Duong PT, Collins HL, Nickel M, Lund-Katz S, Rothblat GH, Phillips MC
Journal of lipid research 2006 Apr;47(4):832-43
Journal of lipid research 2006 Apr;47(4):832-43
Transcriptional repression of ATP-binding cassette transporter A1 gene in macrophages: a novel atherosclerotic effect of angiotensin II.
Takata Y, Chu V, Collins AR, Lyon CJ, Wang W, Blaschke F, Bruemmer D, Caglayan E, Daley W, Higaki J, Fishbein MC, Tangirala RK, Law RE, Hsueh WA
Circulation research 2005 Oct 28;97(9):e88-96
Circulation research 2005 Oct 28;97(9):e88-96
Knockdown of hepatic ABCA1 by RNA interference decreases plasma HDL cholesterol levels and influences postprandial lipemia in mice.
Ragozin S, Niemeier A, Laatsch A, Loeffler B, Merkel M, Beisiegel U, Heeren J
Arteriosclerosis, thrombosis, and vascular biology 2005 Jul;25(7):1433-8
Arteriosclerosis, thrombosis, and vascular biology 2005 Jul;25(7):1433-8
Glycosphingolipid accumulation inhibits cholesterol efflux via the ABCA1/apolipoprotein A-I pathway: 1-phenyl-2-decanoylamino-3-morpholino-1-propanol is a novel cholesterol efflux accelerator.
Glaros EN, Kim WS, Quinn CM, Wong J, Gelissen I, Jessup W, Garner B
The Journal of biological chemistry 2005 Jul 1;280(26):24515-23
The Journal of biological chemistry 2005 Jul 1;280(26):24515-23
ACAT1 deficiency disrupts cholesterol efflux and alters cellular morphology in macrophages.
Dove DE, Su YR, Zhang W, Jerome WG, Swift LL, Linton MF, Fazio S
Arteriosclerosis, thrombosis, and vascular biology 2005 Jan;25(1):128-34
Arteriosclerosis, thrombosis, and vascular biology 2005 Jan;25(1):128-34
The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease.
Koldamova RP, Lefterov IM, Staufenbiel M, Wolfe D, Huang S, Glorioso JC, Walter M, Roth MG, Lazo JS
The Journal of biological chemistry 2005 Feb 11;280(6):4079-88
The Journal of biological chemistry 2005 Feb 11;280(6):4079-88
Genes of cholesterol metabolism in human atheroma: overexpression of perilipin and genes promoting cholesterol storage and repression of ABCA1 expression.
Forcheron F, Legedz L, Chinetti G, Feugier P, Letexier D, Bricca G, Beylot M
Arteriosclerosis, thrombosis, and vascular biology 2005 Aug;25(8):1711-7
Arteriosclerosis, thrombosis, and vascular biology 2005 Aug;25(8):1711-7
The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities.
Makowski L, Brittingham KC, Reynolds JM, Suttles J, Hotamisligil GS
The Journal of biological chemistry 2005 Apr 1;280(13):12888-95
The Journal of biological chemistry 2005 Apr 1;280(13):12888-95
Effects of pravastatin on the expression of ATP-binding cassette transporter A1.
Ando H, Tsuruoka S, Yamamoto H, Takamura T, Kaneko S, Fujimura A
The Journal of pharmacology and experimental therapeutics 2004 Oct;311(1):420-5
The Journal of pharmacology and experimental therapeutics 2004 Oct;311(1):420-5
Characterization of oligomeric human ATP binding cassette transporter A1. Potential implications for determining the structure of nascent high density lipoprotein particles.
Denis M, Haidar B, Marcil M, Bouvier M, Krimbou L, Genest J
The Journal of biological chemistry 2004 Oct 1;279(40):41529-36
The Journal of biological chemistry 2004 Oct 1;279(40):41529-36
Cellular physiology of cholesterol efflux in vascular endothelial cells.
O'Connell BJ, Denis M, Genest J
Circulation 2004 Nov 2;110(18):2881-8
Circulation 2004 Nov 2;110(18):2881-8
Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism.
Zeng L, Liao H, Liu Y, Lee TS, Zhu M, Wang X, Stemerman MB, Zhu Y, Shyy JY
The Journal of biological chemistry 2004 Nov 19;279(47):48801-7
The Journal of biological chemistry 2004 Nov 19;279(47):48801-7
LXR/RXR ligand activation enhances basolateral efflux of beta-sitosterol in CaCo-2 cells.
Field FJ, Born E, Mathur SN
Journal of lipid research 2004 May;45(5):905-13
Journal of lipid research 2004 May;45(5):905-13
Molecular interactions between apoE and ABCA1: impact on apoE lipidation.
Krimbou L, Denis M, Haidar B, Carrier M, Marcil M, Genest J Jr
Journal of lipid research 2004 May;45(5):839-48
Journal of lipid research 2004 May;45(5):839-48
Apolipoprotein A-1 interaction with plasma membrane lipid rafts controls cholesterol export from macrophages.
Gaus K, Kritharides L, Schmitz G, Boettcher A, Drobnik W, Langmann T, Quinn CM, Death A, Dean RT, Jessup W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004 Mar;18(3):574-6
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004 Mar;18(3):574-6
Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter.
Haidar B, Denis M, Marcil M, Krimbou L, Genest J Jr
The Journal of biological chemistry 2004 Mar 12;279(11):9963-9
The Journal of biological chemistry 2004 Mar 12;279(11):9963-9
ABCA1-dependent lipid efflux to apolipoprotein A-I mediates HDL particle formation and decreases VLDL secretion from murine hepatocytes.
Sahoo D, Trischuk TC, Chan T, Drover VA, Ho S, Chimini G, Agellon LB, Agnihotri R, Francis GA, Lehner R
Journal of lipid research 2004 Jun;45(6):1122-31
Journal of lipid research 2004 Jun;45(6):1122-31
Molecular and cellular physiology of apolipoprotein A-I lipidation by the ATP-binding cassette transporter A1 (ABCA1).
Denis M, Haidar B, Marcil M, Bouvier M, Krimbou L, Genest J Jr
The Journal of biological chemistry 2004 Feb 27;279(9):7384-94
The Journal of biological chemistry 2004 Feb 27;279(9):7384-94
Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells.
Bared SM, Buechler C, Boettcher A, Dayoub R, Sigruener A, Grandl M, Rudolph C, Dada A, Schmitz G
Molecular biology of the cell 2004 Dec;15(12):5399-407
Molecular biology of the cell 2004 Dec;15(12):5399-407
Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma.
Li AC, Binder CJ, Gutierrez A, Brown KK, Plotkin CR, Pattison JW, Valledor AF, Davis RA, Willson TM, Witztum JL, Palinski W, Glass CK
The Journal of clinical investigation 2004 Dec;114(11):1564-76
The Journal of clinical investigation 2004 Dec;114(11):1564-76
Oxysterols trigger ABCA1-mediated basolateral surfactant efflux.
Agassandian M, Mathur SN, Zhou J, Field FJ, Mallampalli RK
American journal of respiratory cell and molecular biology 2004 Aug;31(2):227-33
American journal of respiratory cell and molecular biology 2004 Aug;31(2):227-33
Differential expression of cholesterol hydroxylases in Alzheimer's disease.
Brown J 3rd, Theisler C, Silberman S, Magnuson D, Gottardi-Littell N, Lee JM, Yager D, Crowley J, Sambamurti K, Rahman MM, Reiss AB, Eckman CB, Wolozin B
The Journal of biological chemistry 2004 Aug 13;279(33):34674-81
The Journal of biological chemistry 2004 Aug 13;279(33):34674-81
Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR.
Khovidhunkit W, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR
Journal of lipid research 2003 Sep;44(9):1728-36
Journal of lipid research 2003 Sep;44(9):1728-36
Macrophage apolipoprotein A-I expression protects against atherosclerosis in ApoE-deficient mice and up-regulates ABC transporters.
Su YR, Ishiguro H, Major AS, Dove DE, Zhang W, Hasty AH, Babaev VR, Linton MF, Fazio S
Molecular therapy : the journal of the American Society of Gene Therapy 2003 Oct;8(4):576-83
Molecular therapy : the journal of the American Society of Gene Therapy 2003 Oct;8(4):576-83
Macrophage apolipoprotein A-I expression protects against atherosclerosis in ApoE-deficient mice and up-regulates ABC transporters.
Su YR, Ishiguro H, Major AS, Dove DE, Zhang W, Hasty AH, Babaev VR, Linton MF, Fazio S
Molecular therapy : the journal of the American Society of Gene Therapy 2003 Oct;8(4):576-83
Molecular therapy : the journal of the American Society of Gene Therapy 2003 Oct;8(4):576-83
Identification and characterization of rodent ABCA1 in isolated type II pneumocytes.
Bortnick AE, Favari E, Tao JQ, Francone OL, Reilly M, Zhang Y, Rothblat GH, Bates SR
American journal of physiology. Lung cellular and molecular physiology 2003 Oct;285(4):L869-78
American journal of physiology. Lung cellular and molecular physiology 2003 Oct;285(4):L869-78
Ceramide enhances cholesterol efflux to apolipoprotein A-I by increasing the cell surface presence of ATP-binding cassette transporter A1.
Witting SR, Maiorano JN, Davidson WS
The Journal of biological chemistry 2003 Oct 10;278(41):40121-7
The Journal of biological chemistry 2003 Oct 10;278(41):40121-7
Expression of sterol 27-hydroxylase (CYP27A1) enhances cholesterol efflux.
Escher G, Krozowski Z, Croft KD, Sviridov D
The Journal of biological chemistry 2003 Mar 28;278(13):11015-9
The Journal of biological chemistry 2003 Mar 28;278(13):11015-9
Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion.
Sun Y, Yao J, Kim TW, Tall AR
The Journal of biological chemistry 2003 Jul 25;278(30):27688-94
The Journal of biological chemistry 2003 Jul 25;278(30):27688-94
Experimental glomerulopathy alters renal cortical cholesterol, SR-B1, ABCA1, and HMG CoA reductase expression.
Johnson AC, Yabu JM, Hanson S, Shah VO, Zager RA
The American journal of pathology 2003 Jan;162(1):283-91
The American journal of pathology 2003 Jan;162(1):283-91
A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I.
Wang N, Chen W, Linsel-Nitschke P, Martinez LO, Agerholm-Larsen B, Silver DL, Tall AR
The Journal of clinical investigation 2003 Jan;111(1):99-107
The Journal of clinical investigation 2003 Jan;111(1):99-107
Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations.
Basso F, Freeman L, Knapper CL, Remaley A, Stonik J, Neufeld EB, Tansey T, Amar MJ, Fruchart-Najib J, Duverger N, Santamarina-Fojo S, Brewer HB Jr
Journal of lipid research 2003 Feb;44(2):296-302
Journal of lipid research 2003 Feb;44(2):296-302
T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice.
Terasaka N, Hiroshima A, Koieyama T, Ubukata N, Morikawa Y, Nakai D, Inaba T
FEBS letters 2003 Feb 11;536(1-3):6-11
FEBS letters 2003 Feb 11;536(1-3):6-11
T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice.
Terasaka N, Hiroshima A, Koieyama T, Ubukata N, Morikawa Y, Nakai D, Inaba T
FEBS letters 2003 Feb 11;536(1-3):6-11
FEBS letters 2003 Feb 11;536(1-3):6-11
Proximal tubular cholesterol loading after mitochondrial, but not glycolytic, blockade.
Zager RA, Johnson AC, Hanson SY
American journal of physiology. Renal physiology 2003 Dec;285(6):F1092-9
American journal of physiology. Renal physiology 2003 Dec;285(6):F1092-9
Visualizing lipid structure and raft domains in living cells with two-photon microscopy.
Gaus K, Gratton E, Kable EP, Jones AS, Gelissen I, Kritharides L, Jessup W
Proceedings of the National Academy of Sciences of the United States of America 2003 Dec 23;100(26):15554-9
Proceedings of the National Academy of Sciences of the United States of America 2003 Dec 23;100(26):15554-9
Regulation of ABCA1 expression and cholesterol efflux during adipose differentiation of 3T3-L1 cells.
Le Lay S, Robichon C, Le Liepvre X, Dagher G, Ferre P, Dugail I
Journal of lipid research 2003 Aug;44(8):1499-507
Journal of lipid research 2003 Aug;44(8):1499-507
Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression.
Wagner BL, Valledor AF, Shao G, Daige CL, Bischoff ED, Petrowski M, Jepsen K, Baek SH, Heyman RA, Rosenfeld MG, Schulman IG, Glass CK
Molecular and cellular biology 2003 Aug;23(16):5780-9
Molecular and cellular biology 2003 Aug;23(16):5780-9
Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression.
Wagner BL, Valledor AF, Shao G, Daige CL, Bischoff ED, Petrowski M, Jepsen K, Baek SH, Heyman RA, Rosenfeld MG, Schulman IG, Glass CK
Molecular and cellular biology 2003 Aug;23(16):5780-9
Molecular and cellular biology 2003 Aug;23(16):5780-9
22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion.
Koldamova RP, Lefterov IM, Ikonomovic MD, Skoko J, Lefterov PI, Isanski BA, DeKosky ST, Lazo JS
The Journal of biological chemistry 2003 Apr 11;278(15):13244-56
The Journal of biological chemistry 2003 Apr 11;278(15):13244-56
ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity.
Feng B, Tabas I
The Journal of biological chemistry 2002 Nov 8;277(45):43271-80
The Journal of biological chemistry 2002 Nov 8;277(45):43271-80
ATP-binding cassette transporter 1 participates in LDL oxidation by artery wall cells.
Reddy ST, Hama S, Ng C, Grijalva V, Navab M, Fogelman AM
Arteriosclerosis, thrombosis, and vascular biology 2002 Nov 1;22(11):1877-83
Arteriosclerosis, thrombosis, and vascular biology 2002 Nov 1;22(11):1877-83
ATP-binding cassette transporter 1 participates in LDL oxidation by artery wall cells.
Reddy ST, Hama S, Ng C, Grijalva V, Navab M, Fogelman AM
Arteriosclerosis, thrombosis, and vascular biology 2002 Nov 1;22(11):1877-83
Arteriosclerosis, thrombosis, and vascular biology 2002 Nov 1;22(11):1877-83
LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells.
Murthy S, Born E, Mathur SN, Field FJ
Journal of lipid research 2002 Jul;43(7):1054-64
Journal of lipid research 2002 Jul;43(7):1054-64
LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells.
Murthy S, Born E, Mathur SN, Field FJ
Journal of lipid research 2002 Jul;43(7):1054-64
Journal of lipid research 2002 Jul;43(7):1054-64
cAMP induces ABCA1 phosphorylation activity and promotes cholesterol efflux from fibroblasts.
Haidar B, Denis M, Krimbou L, Marcil M, Genest J Jr
Journal of lipid research 2002 Dec;43(12):2087-94
Journal of lipid research 2002 Dec;43(12):2087-94
cAMP induces ABCA1 phosphorylation activity and promotes cholesterol efflux from fibroblasts.
Haidar B, Denis M, Krimbou L, Marcil M, Genest J Jr
Journal of lipid research 2002 Dec;43(12):2087-94
Journal of lipid research 2002 Dec;43(12):2087-94
Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels.
Fukumoto H, Deng A, Irizarry MC, Fitzgerald ML, Rebeck GW
The Journal of biological chemistry 2002 Dec 13;277(50):48508-13
The Journal of biological chemistry 2002 Dec 13;277(50):48508-13
Trypsin-sensitive and lipid-containing sites of the macrophage extracellular matrix bind apolipoprotein A-I and participate in ABCA1-dependent cholesterol efflux.
Burgess JW, Kiss RS, Zheng H, Zachariah S, Marcel YL
The Journal of biological chemistry 2002 Aug 30;277(35):31318-26
The Journal of biological chemistry 2002 Aug 30;277(35):31318-26
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Supportive validation
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- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: ABCA1 Antibody [NB400-105] - Western Blot analysis of ABCA1 in total cell lysates of RAW264.9 cells treated with vehicle (-) or 9-cisretinoic acid and 22Rhydroxycholesterol (+). Samples used for this testing were 40 ug of total cell post-nuclear lysate from each group.
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- Experimental details
- Western Blot: ABCA1 Antibody [NB400-105] - Analysis of ABCA1, using NB400-105. Samples: 40 ug of total cell post-nuclear lysate of raw macrophages treated with 9-cisretinoic acid and 22R-hydroxycholesterol.
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- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: ABCA1 Antibody [NB400-105] - Detection of ABCA1 in mouse peritoneal macrophages using NB 400-105 (Lot L). ECL exposure, 1 min. Lane 4: T09 uninduced lysate Lane 5: T09 induced lysate.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: ABCA1 Antibody [NB400-105] - Analysis of ABCA1 in total cell lysates of RAW264.9 cells treated with vehicle (-) or 9-cisretinoic acid and 22Rhydroxycholesterol (+). Samples used for this testing were 40 ug of total cell post-nuclear lysate from each group.
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- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: ABCA1 Antibody [NB400-105] - miR-33b regulates ABCA1 and SREBP-1. Analysis for ABCA1, SREBP-1, CPT1a, and AMPK alpha protein levels in the livers of WT, KI+/-, and KI+/+ mice. Representative images are shown. TF2B and beta-actin were used as loading controls. Image collected and cropped by CiteAb from the following publication (http://www.nature.com/articles/srep05312), licensed under a CC-BY licence.
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- Western Blot: ABCA1 Antibody [NB400-105] - Prostates of LXR mutant mice accumulate cholesterol esters through inappropriate LXR target genes regulation. Total protein lysates of WT and LXR null mice under normal or high cholesterol diet were analyzed by western blotting with antibodies against ABCA1, LDLR and ACTIN as a loading control (left panel), quantification of ABCA1 and LDLR protein accumulation levels (right panel). * p
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- Western Blot: ABCA1 Antibody [NB400-105] - miR-33b reduces cellular cholesterol efflux and serum HDL-C levels. Western blotting for ABCA1 (using NB400-105) and ABCG1 proteins in peritoneal macrophages from WT and KI+/+ mice. Representative images are shown. beta-actin was used as the loading control. Image collected and cropped by CiteAb from the following publication (http://www.nature.com/articles/srep05312), licensed under a CC-BY licence.
Supportive validation
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- Novus Biologicals (provider)
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- Immunohistochemistry-Paraffin: ABCA1 Antibody [NB400-105] - Detection of ABCA1 in human prostate epithelium showing luminal and membrane staining.
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- Immunohistochemistry-Paraffin: ABCA1 Antibody [NB400-105] - Association between expression of ABCA1 and survival in ovarian cancer patients. Expression of ABCA1 in 55 ovarian cancer patient samples was determined by IHC in tissue microarray. Representative image of ovarian cancer showing high (left panel) and low (right panel) ABCA1 expression on the cell membrane or cytoplasm (x400). Image collected and cropped by CiteAb from the following publication (http://www.clinicalepigeneticsjournal.com/content/7/1/1), licensed under a CC-BY licence.
Supportive validation
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- Flow Cytometry: ABCA1 Antibody [NB400-105] - ABCA1 antibody was tested at 1: 400 in HeLa cells using an Alexa Fluor 488 secondary (shown in purple). M1 is defined by unstained cells.
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- Flow Cytometry: ABCA1 Antibody [NB400-105] - ABCA-1 FITC conjugated antibody of human adipose tissue macrophage subsets by flow cytometry. Image from verified customer review.
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- Flow (Cell Surface): ABCA1 Antibody [NB400-105] - RAW 246.7 cells were either untreated (A) or serum starved for 24 hours, and then treated with 1uM TO9 for 24 hours (B). A surface stain was performed with ABCA1 Antibody NB400-105 (blue) and a matched isotype control NB810-56910 (orange). Cells were incubated in an antibody dilution of 5 ug/mL for 20 minutes at room temperature, followed by Goat Anti-Rabbit Dylight 550-conjugated antibody (SA5-10033, Thermo Fisher).
