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ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [10]
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- Western blot [1]
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- Product number
- NB100-180 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-180, RRID:AB_10002675
- Product name
- Mouse Monoclonal XRCC3 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A purified. This is specific for XRCC3. NB100-180 does not cross-react with Rad51B, Rad51C, Rad51D, Rad51, or XRCC2 in Western analysis.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1 mg/ml
- Storage
- Store at 4C. Do not freeze.
Submitted references Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway.
Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome.
Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C.
Dysfunctional homologous recombination mediates genomic instability and progression in myeloma.
WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening.
Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance.
Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells.
Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51.
Xrcc3 is recruited to DNA double strand breaks early and independent of Rad51.
Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression.
Chun J, Buechelmaier ES, Powell SN
Molecular and cellular biology 2013 Jan;33(2):387-95
Molecular and cellular biology 2013 Jan;33(2):387-95
Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome.
Sage JM, Gildemeister OS, Knight KL
The Journal of biological chemistry 2010 Jun 18;285(25):18984-90
The Journal of biological chemistry 2010 Jun 18;285(25):18984-90
Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C.
Gildemeister OS, Sage JM, Knight KL
The Journal of biological chemistry 2009 Nov 13;284(46):31945-52
The Journal of biological chemistry 2009 Nov 13;284(46):31945-52
Dysfunctional homologous recombination mediates genomic instability and progression in myeloma.
Shammas MA, Shmookler Reis RJ, Koley H, Batchu RB, Li C, Munshi NC
Blood 2009 Mar 5;113(10):2290-7
Blood 2009 Mar 5;113(10):2290-7
WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening.
Li B, Jog SP, Reddy S, Comai L
Molecular and cellular biology 2008 Mar;28(6):1892-904
Molecular and cellular biology 2008 Mar;28(6):1892-904
Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance.
Chan N, Koritzinsky M, Zhao H, Bindra R, Glazer PM, Powell S, Belmaaza A, Wouters B, Bristow RG
Cancer research 2008 Jan 15;68(2):605-14
Cancer research 2008 Jan 15;68(2):605-14
Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells.
Compton SA, Choi JH, Cesare AJ, Ozgür S, Griffith JD
Cancer research 2007 Feb 15;67(4):1513-9
Cancer research 2007 Feb 15;67(4):1513-9
Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51.
Bennett BT, Knight KL
Journal of cellular biochemistry 2005 Dec 15;96(6):1095-109
Journal of cellular biochemistry 2005 Dec 15;96(6):1095-109
Xrcc3 is recruited to DNA double strand breaks early and independent of Rad51.
Forget AL, Bennett BT, Knight KL
Journal of cellular biochemistry 2004 Oct 15;93(3):429-36
Journal of cellular biochemistry 2004 Oct 15;93(3):429-36
Defective DNA strand break repair after DNA damage in prostate cancer cells: implications for genetic instability and prostate cancer progression.
Fan R, Kumaravel TS, Jalali F, Marrano P, Squire JA, Bristow RG
Cancer research 2004 Dec 1;64(23):8526-33
Cancer research 2004 Dec 1;64(23):8526-33
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: XRCC3 Antibody (10F1/6) [NB100-180] - XRCC3 detected in HEK293 lysates using a 1:1000 dilution of Protein A purified NB100-180. Photo courtesy of B.T. Bennett & K. Knight of University of Massachusetts Medical School.
