TONSL

The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008]

Description

Tonsoku like, DNA repair protein

Tissue specificity

Tissue enhanced (bone marrow)

Subcell location

Nucleoplasm, Nuclear bodies

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

8 (144428775 - 144444440)

Ensembl ID

ENSG00000160949  (ver. 103.38)

Orthologs

Mouse Tonsl: ENSMUSG00000059323

UniProt

Q96HA7

neXtProt

NX_Q96HA7

Human splice variants
Mouse splice variants

Protein structure