15462-1-AP

antibody from Proteintech Group

Targeting: MDH2

Provider product page for 15462-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [31]
Comments [0]
Validations
Western blot [1]

Submit

Product number: 15462-1-AP - Provider product page
Provider: Proteintech Group
Product name: MDH2 antibody
Antibody type: Polyclonal
Description: MDH2 antibody (Cat. #15462-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MDH2 protein structure - 15462-1-AP shown in red.

Submitted references Protein S-acylation dynamics provide metabolic plasticity to acute myeloid leukemia cells.

Balasundaram N, Erdem A, Sharda A, Daniels VW, Chea PL, Leguay F, Liu Y, Keibler MA, Vidoudez C, Lane AA, Vertommen D, Casteur H, Laurent MR, Trauger SA, Stephanopoulos G, Scadden DT, van Gastel N
bioRxiv : the preprint server for biology 2026 Mar 3;

Curcumin inhibits colorectal cancer progression by regulating MDH2-mediated glycolysis and NAD(+) metabolism.

Zhao Y, Qin H, Sun W, Chen Y, Wang R, Li C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2026 Jul;213:116074

Hypothalamic malate dehydrogenase 2 modulates systemic glucose metabolism through oxytocin-mediated thermogenesis.

Yao T, Wu G, Zeng Y, Xie Y, Cui X, Zhang Q, Yan C, Cui Z, Gong H, Xiong T, Liang X, Zhang Y, Zheng R, Wang H, Gao M, Zhang P, Wang R, Zhao X, Feng Z, Xiao L, Liu T, Zhang Z
Cell reports. Medicine 2026 Feb 17;7(2):102616

Multi-Omics Insights into the Impact of MDH2 on Breast Cancer Progression: A Promising Druggable Target.

Pan B, Luo Z, Yang X, Liu Q, Yang Z, Xia C
Oncology research 2025;33(11):3557-3582

β-Hydroxybutyrate enhances malate dehydrogenase 2 β-hydroxybutyrylation to alleviate hepatic steatosis in MASLD.

Cai J, Li W, Wu C, Ni H, Ran H, Huang Y, Tang X, He W, Gu Y, You Y, Li J, Xiao X, Ma L
Cellular and molecular life sciences : CMLS 2025 Oct 24;82(1):361

Succinate dehydrogenase activity supports de novo purine synthesis.

Nengroo MA, Klein AT, Carr HS, Vidal-Cruchez O, Sahu U, McGrail DJ, Sahni N, Gao P, Asara JM, Shah H, Mendillo ML, Ben-Sahra I
bioRxiv : the preprint server for biology 2025 Mar 1;

Protein lactylation of citrate synthase promotes the AKI-CKD transition by activating the NLRP3 inflammasome.

Yu F, Meng Y, Wang X, Chen J, He J, Yi X, He Y, Chen K
Cell reports 2025 Aug 26;44(8):116084

Nucleolin lactylation contributes to intrahepatic cholangiocarcinoma pathogenesis via RNA splicing regulation of MADD.

Yang L, Niu K, Wang J, Shen W, Jiang R, Liu L, Song W, Wang X, Zhang X, Zhang R, Wei D, Fan M, Jia L, Tao K
Journal of hepatology 2024 Oct;81(4):651-666

N-Terminomic Identification of Intracellular MMP-2 Substrates in Cardiac Tissue.

Hartley B, Bassiouni W, Roczkowsky A, Fahlman R, Schulz R, Julien O
Journal of proteome research 2024 Oct 4;23(10):4188-4202

MDH2 Promotes Hepatocellular Carcinoma Growth Through Ferroptosis Evasion via Stabilizing GPX4.

Yu W, Li Y, Gao C, Li D, Chen L, Dai B, Yang H, Han L, Deng Q, Bian X
International journal of molecular sciences 2024 Oct 29;25(21)

Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2.

Lv D, Dixit D, Cruz AF, Kim LJY, Duan L, Xu X, Wu Q, Zhong C, Lu C, Gersey ZC, Gimple RC, Xie Q, Yang K, Liu X, Fang X, Wu X, Kidwell RL, Wang X, Bao S, He HH, Locasale JW, Agnihotri S, Rich JN
Cell metabolism 2024 Nov 5;36(11):2419-2436.e8

Cytosolic RNA binding of the mitochondrial TCA cycle enzyme malate dehydrogenase.

Noble M, Chatterjee A, Sekaran T, Schwarzl T, Hentze MW
RNA (New York, N.Y.) 2024 Jun 17;30(7):839-853

Mammalian target of differentiation-inducing factor-1 is mitochondrial malate dehydrogenase for activation of AMP-activated protein kinase and induction of mitochondrial fission.

Arioka M, Miura K, Han R, Igawa K, Takahashi-Yanaga F, Sasaguri T
Life sciences 2024 Aug 15;351:122807

MDH2 regulates the sensitivity of clear cell renal cell carcinoma to ferroptosis through its interaction with FSP1.

Feng B, Su W, Guo X, Ding T, Duan Y, Hu L, Yu M
Cell death discovery 2024 Aug 13;10(1):363

Mitovesicles secreted into the extracellular space of brains with mitochondrial dysfunction impair synaptic plasticity.

D'Acunzo P, Argyrousi EK, Ungania JM, Kim Y, DeRosa S, Pawlik M, Goulbourne CN, Arancio O, Levy E
Molecular neurodegeneration 2024 Apr 14;19(1):34

Role of asparagine biosynthesis pathway in Siniperca chuatsi rhabdovirus proliferation.

Li F, Fu X, Luo X, Lin Q, Liang H, Niu Y, Liu L, Li N
Frontiers in microbiology 2023;14:1165491

Inhibition of fatty acid oxidation enables heart regeneration in adult mice.

Li X, Wu F, Günther S, Looso M, Kuenne C, Zhang T, Wiesnet M, Klatt S, Zukunft S, Fleming I, Poschet G, Wietelmann A, Atzberger A, Potente M, Yuan X, Braun T
Nature 2023 Oct;622(7983):619-626

Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas.

Gao Y, Long Q, Yang H, Hu Y, Xu Y, Tang C, Gu C, Yong S
Experimental and therapeutic medicine 2023 Nov;26(5):533

SUCLG2 Regulates Mitochondrial Dysfunction through Succinylation in Lung Adenocarcinoma.

Hu Q, Xu J, Wang L, Yuan Y, Luo R, Gan M, Wang K, Zhao T, Wang Y, Han T, Wang JB
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(35):e2303535

Inosine enhances tumor mitochondrial respiration by inducing Rag GTPases and nascent protein synthesis under nutrient starvation.

Li MX, Wu XT, Jing WQ, Hou WK, Hu S, Yan W
Cell death & disease 2023 Aug 2;14(8):492

Dietary Salt Disrupts Tricarboxylic Acid Cycle and Induces Tau Hyperphosphorylation and Synapse Dysfunction during Aging.

Yuan M, Wang Y, Wen J, Jing F, Zou Q, Pu Y, Pan T, Cai Z
Aging and disease 2022 Oct 1;13(5):1532-1545

AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology.

Tilokani L, Russell FM, Hamilton S, Virga DM, Segawa M, Paupe V, Gruszczyk AV, Protasoni M, Tabara LC, Johnson M, Anand H, Murphy MP, Hardie DG, Polleux F, Prudent J
Science advances 2022 Nov 11;8(45):eabo7956

Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin.

Head PE, Myung S, Chen Y, Schneller JL, Wang C, Duncan N, Hoffman P, Chang D, Gebremariam A, Gucek M, Manoli I, Venditti CP
Science translational medicine 2022 May 25;14(646):eabn4772

Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk.

Wang XH, Xu S, Zhou XY, Zhao R, Lin Y, Cao J, Zang WD, Tao H, Xu W, Li MQ, Zhao SM, Jin LP, Zhao JY
Nature communications 2021 Jun 8;12(1):3428

Inhibiting both proline biosynthesis and lipogenesis synergistically suppresses tumor growth.

Liu M, Wang Y, Yang C, Ruan Y, Bai C, Chu Q, Cui Y, Chen C, Ying G, Li B
The Journal of experimental medicine 2020 Mar 2;217(3)

Genome-wide translational reprogramming of genes important for myocyte functions in overload-induced heart failure.

Guo Q, Zhang Y, Zhang S, Jin J, Pang S, Wu X, Zhang W, Bi X, Zhang Y, Zhang Q, Jiang F
Biochimica et biophysica acta. Molecular basis of disease 2020 Mar 1;1866(3):165649

The Symbiotic Relationship between the Neural Retina and Retinal Pigment Epithelium Is Supported by Utilizing Differential Metabolic Pathways.

Sinha T, Naash MI, Al-Ubaidi MR
iScience 2020 Apr 24;23(4):101004

LONP1 Is Required for Maturation of a Subset of Mitochondrial Proteins, and Its Loss Elicits an Integrated Stress Response.

Zurita Rendón O, Shoubridge EA
Molecular and cellular biology 2018 Oct 15;38(20)

Coupling of oxidative stress responses to tricarboxylic acid cycle and prostaglandin E(2) alterations in Caenorhabditis elegans under extremely low-frequency electromagnetic field.

Sun Y, Shi Z, Wang Y, Tang C, Liao Y, Yang C, Cai P
International journal of radiation biology 2018 Dec;94(12):1159-1166

Effects of Dahuang zhechong pill on doxorubicin-resistant SMMC-7721 xenografts in mice.

Wu L, Cao KX, Ni ZH, Li WD, Chen ZP, Cheng HB, Liu X
Journal of ethnopharmacology 2018 Aug 10;222:71-78

Human METTL12 is a mitochondrial methyltransferase that modifies citrate synthase.

Rhein VF, Carroll J, Ding S, Fearnley IM, Walker JE
FEBS letters 2017 Jun;591(12):1641-1652

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The MDH2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MDH2. This antibody recognizes human,mouse,rat antigen. The MDH2 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 15462-1-AP.pdf

: Show more