MDH2

Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Description

malate dehydrogenase 2

Protein family

Citric acid cycle related proteins, Disease related genes, Enzymes, FDA approved drug targets, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

7:q11.23 (76048051 - 76067508)

Ensembl ID

ENSG00000146701  (ver. 98.38)

Orthologs

Mouse Mdh2: ENSMUSG00000019179

UniProt

P40926

neXtProt

NX_P40926

Human splice variants
Mouse splice variants