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Protein structure
IL12RB1
Interleukin 12 receptor subunit beta 1CD212, IL12RB
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Top validated antibodies |
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| Biorbyt |  orb13492 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| GeneTex | GTX55677 |
Polyclonal |
WB
ICC
IHC
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| antibodies-online | ABIN3197956 |
Polyclonal |
WB
ICC
IHC
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| Bioss | bs-2603R |
1 references | Polyclonal |
WB
ICC
IHC
FC
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| Novus Biologicals | NBP1-49875 |
1 references | Polyclonal |
WB
EL
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