CABT-BL1915

antibody from Creative Diagnostics

Targeting: IL12RB1 CD212, IL12RB

Western blot (Recommended by provider)

Antibody Data

Product number

CABT-BL1915

Provider

Creative Diagnostics

Product name

Anti-IL12RB1 (aa 57-458) polyclonal antibody

Antibody type

Polyclonal

Description

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Storage

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.