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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Flow cytometry [1]
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- Product number
- 920008 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#920008, RRID:AB_2629780
- Product name
- PE anti-human/rat CD51 (Integrin αvβ5)
- Antibody type
- Monoclonal
- Description
- CD51 is a type I integral membrane glycoprotein, known as vitronectin receptor α chain, or integrin αV. It forms heterodimer with integrin β1 (CD29), β3 (CD61), β5, β6, or β8. CD51 contains two disulfide-linked subunits of 125 kD and 24 kD, and is expressed on endothelial cells, fibroblasts, macrophages, platelets, osteoclasts, neuroblastoma, melanoma, and hepatoma cells. Many extracellular matrix proteins with RGD-motifs are CD51 ligands. In association with its β chains, CD51 binds vitronectin, von Willebrand factor, fibronectin, thrombospondin, osteopontin, fibrinogen, and laminin. CD51, as an adhesion molecule, plays important roles in leukocytes homing and rolling and mediates bone absorption and angiogenesis.
- Reactivity
- Human, Rat, Hamster
- Host
- Mouse
- Conjugate
- Yellow dye
- Antibody clone number
- P1F6
- Vial size
- 100 tests
- Storage
- 2°C-8°C
- Handling
- Ambient RT
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human fibrocarcinoma cell line HT1080 was stained with CD51 (clone P1F6) PE (closed histogram) or mouse IgG1, κ PE isotype control (open histogram).
- Conjugate
- Yellow dye
