Tissue expression
Cell line expression
Protein structure
ITGAV
Integrin subunit alpha VCD51, MSK8, VNRA, VTNR
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
Top validated antibodies |
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GeneTex | GTX100789 | 4 references | Polyclonal |
WB
EL
IHC
|
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Novus Biologicals | NB100-2618 | 1 references | Monoclonal |
WB
ICC
IP
IHC
FC
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R&D Systems | AF1219 | 3 references | Polyclonal |
WB
ICC
FC
|
|
OriGene | AM26367FC-N | Monoclonal |
EL
ICC
IP
IHC
FC
|
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Invitrogen Antibodies | MA5-32195 | 1 references | Monoclonal |
WB
ICC
FC
|
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