RA0433

antibody from Oursmab

Targeting: ITGAV CD51, MSK8, VNRA, VTNR

Western blot (Data presented on provider website)

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0433

Provider

Oursmab

Product name

Intetumumab (Biosimilar Reference Antibody) (ITGAVB3)

Antibody type

Monoclonal

Description

Intetumumab (development code CNTO-95) is an investigational, fully human monoclonal IgG1 antibody developed for the treatment of solid tumors. It functions as a pan-integrin inhibitor, specifically targeting the alpha-v (¦Áv) integrin family. By binding with high affinity, intetumumab blocks the activity of multiple integrins containing the ¦Áv subunit, including ¦Áv¦Â3, ¦Áv¦Â5, and ¦Áv¦Â6. These integrins are key receptors that mediate cell adhesion to the extracellular matrix (ECM) and transduce signals regulating cell survival, proliferation, migration, and angiogenesis. The blockade of these pathways by intetumumab aims to inhibit tumor growth, angiogenesis, and metastasis.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.