Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 327907 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#327907, RRID:AB_940558
- Product name
- FITC anti-human CD51
- Antibody type
- Monoclonal
- Antigen
- Melonama cells
- Description
- CD51 is a type I integral membrane glycoprotein, known as vitronectin receptor α chain, or integrin αV. It forms heterodimer with integrin β1 (CD29), β3 (CD61), β5, β6, or β8. CD51 contains two disulfide-linked subunits of 125 kD and 24 kD, and is expressed on endothelial cells, fibroblasts, macrophages, platelets, osteoclasts, neuroblastoma, melanoma, and hepatoma cells. Many extracellular matrix proteins with RGD-motifs are CD51 ligands. In association with its β chains, CD51 binds vitronectin, von Willebrand factor, fibronectin, thrombospondin, osteopontin, fibrinogen, and laminin. CD51, as an adhesion molecule, plays important roles in leukocytes homing and rolling, mediates bone absorption and angiogenesis.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Green dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references Colon carcinoma cell glycolipids, integrins, and other glycoproteins mediate adhesion to HUVECs under flow.
Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8.
Burdick MM, McCaffery JM, Kim YS, Bochner BS, Konstantopoulos K
American journal of physiology. Cell physiology 2003 Apr;284(4):C977-87
American journal of physiology. Cell physiology 2003 Apr;284(4):C977-87
Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8.
Sonnenberg A, Linders CJ, Modderman PW, Damsky CH, Aumailley M, Timpl R
The Journal of cell biology 1990 Jun;110(6):2145-55
The Journal of cell biology 1990 Jun;110(6):2145-55
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human melanoma cell line M21 stained with NKI-M9 FITC
- Conjugate
- Green dye