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- Antigen structure
- References [84]
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- Product number
- 600-401-394S - Provider product page
- Provider
- Rockland Immunochemicals, Inc.
- Proper citation
- Rockland Cat#600-401-394S, RRID:AB_11179937
- Product name
- Anti-Mcl-1 (RABBIT) Antibody - 600-401-394S
- Antibody type
- Polyclonal
- Vial size
- 25 µl
Submitted references Chronic spindle assembly checkpoint activation causes myelosuppression and gastrointestinal atrophy.
LINC complex protein nesprin-2 has pro-apoptotic activity via Bcl-2 family proteins.
The SARS-CoV-2 spike glycoprotein interacts with MAO-B and impairs mitochondrial energetics.
Mitophagy restricts BAX/BAK-independent, Parkin-mediated apoptosis.
Mitochondrial E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins.
Porphyromonas gingivalis Peptidyl Arginine Deiminase (PPAD) in the Context of the Feed-Forward Loop of Inflammation in Periodontitis.
MCL-1 is a master regulator of cancer dependency on fatty acid oxidation.
Ca(2+)-mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak.
Mcl-1 Differentially Regulates Autophagy in Response to Changes in Energy Status and Mitochondrial Damage.
Inhibition of the Anti-Apoptotic Bcl-2 Family by BH3 Mimetics Sensitize the Mitochondrial Permeability Transition Pore Through Bax and Bak.
The Role of Mcl-1 in Embryonic Neural Precursor Cell Apoptosis.
p53-Independent Induction of p21 Fails to Control Regeneration and Hepatocarcinogenesis in a Murine Liver Injury Model.
Ser9 phosphorylation of GSK-3β promotes aging in the heart through suppression of autophagy.
Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis, and tumorigenesis.
Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation.
The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics.
Requirement for antiapoptotic MCL-1 during early erythropoiesis.
Mcl-1-mediated mitochondrial fission protects against stress but impairs cardiac adaptation to exercise.
Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1.
Hepatocyte apoptosis is tumor promoting in murine nonalcoholic steatohepatitis.
Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.
MCL-1 is essential for survival but dispensable for metabolic fitness of FOXP3(+) regulatory T cells.
MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex.
In the absence of apoptosis, myeloid cells arrest when deprived of growth factor, but remain viable by consuming extracellular glucose.
Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis.
DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-β signaling pathway.
CHK1 dosage in germinal center B cells controls humoral immunity.
The AKT isoforms 1 and 2 drive B cell fate decisions during the germinal center response.
Mcl-1 and Bcl-xL are essential for survival of the developing nervous system.
Infection with flaviviruses requires BCLXL for cell survival.
Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer.
Requirement of GSK-3 for PUMA induction upon loss of pro-survival PI3K signaling.
Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD.
Differential effects of Vav-promoter-driven overexpression of BCLX and BFL1 on lymphocyte survival and B cell lymphomagenesis.
Dynein light chain 1 induces assembly of large Bim complexes on mitochondria that stabilize Mcl-1 and regulate apoptosis.
Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins.
The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.
Post-translational control of T cell development by the ESCRT protein CHMP5.
MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis.
Corrigendum: Distinct Transcriptomic Features Are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen.
Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins.
Structure-function insights reveal the human ribosome as a cancer target for antibiotics.
Allosteric inhibition of antiapoptotic MCL-1.
The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland.
Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response.
The anti-apoptotic Bcl-2 family protein A1/Bfl-1 regulates neutrophil survival and homeostasis and is controlled via PI3K and JAK/STAT signaling.
Anti-apoptotic Bcl-XL but not Mcl-1 contributes to protection against virus-induced apoptosis.
Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.
Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury.
Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury.
An interconnected hierarchical model of cell death regulation by the BCL-2 family.
Mcl-1 is a key regulator of the ovarian reserve.
Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics.
Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in Mice.
BH3-only protein BIM mediates heat shock-induced apoptosis.
HTLV-1 tax stabilizes MCL-1 via TRAF6-dependent K63-linked polyubiquitination to promote cell survival and transformation.
Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function.
RAF and antioxidants prevent cell death induction after growth factor abrogation through regulation of Bcl-2 proteins.
Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1.
Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure.
Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons.
Mcl1 regulates the terminal mitosis of neural precursor cells in the mammalian brain through p27Kip1.
Obesity promotes liver carcinogenesis via Mcl-1 stabilization independent of IL-6Rα signaling.
Oncogenic kit triggers Shp2/Erk1/2 pathway to down-regulate the pro-apoptotic protein Bim and to promote apoptosis resistance in leukemic cells.
miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes.
Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo.
Mcl-1 regulates the survival of adult neural precursor cells.
A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).
BH3 domains other than Bim and Bid can directly activate Bax/Bak.
In vivo activity of combined PI3K/mTOR and MEK inhibition in a Kras(G12D);Pten deletion mouse model of ovarian cancer.
c-Myb promotes the survival of CD4+CD8+ double-positive thymocytes through upregulation of Bcl-xL.
Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development.
Mitophagy in mammalian cells: the reticulocyte model.
Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver.
Mcl-1 degradation during hepatocyte lipoapoptosis.
Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors.
BH3-only protein bid participates in the Bcl-2 network in healthy liver cells.
The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages.
Triggering of apoptosis by Puma is determined by the threshold set by prosurvival Bcl-2 family proteins.
NIX is required for programmed mitochondrial clearance during reticulocyte maturation.
Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion.
Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.
Dominant negative retinoic acid receptor initiates tumor formation in mice.
Karbon G, Schuler F, Braun VZ, Eichin F, Haschka M, Drach M, Sotillo R, Geley S, Spierings DC, Tijhuis AE, Foijer F, Villunger A
EMBO reports 2024 Jun;25(6):2743-2772
EMBO reports 2024 Jun;25(6):2743-2772
LINC complex protein nesprin-2 has pro-apoptotic activity via Bcl-2 family proteins.
Lindenboim L, Zohar H, Gundersen GG, Worman HJ, Stein R
Cell death discovery 2024 Jan 15;10(1):29
Cell death discovery 2024 Jan 15;10(1):29
The SARS-CoV-2 spike glycoprotein interacts with MAO-B and impairs mitochondrial energetics.
Pileggi CA, Parmar G, Elkhatib H, Stewart CM, Alecu I, Côté M, Bennett SAL, Sandhu JK, Cuperlovic-Culf M, Harper ME
Current research in neurobiology 2023;5:100112
Current research in neurobiology 2023;5:100112
Mitophagy restricts BAX/BAK-independent, Parkin-mediated apoptosis.
Quarato G, Mari L, Barrows NJ, Yang M, Ruehl S, Chen MJ, Guy CS, Low J, Chen T, Green DR
Science advances 2023 May 24;9(21):eadg8156
Science advances 2023 May 24;9(21):eadg8156
Mitochondrial E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins.
Huang AS, Chin HS, Reljic B, Djajawi TM, Tan IKL, Gong JN, Stroud DA, Huang DCS, van Delft MF, Dewson G
Cell death and differentiation 2023 Mar;30(3):632-646
Cell death and differentiation 2023 Mar;30(3):632-646
Porphyromonas gingivalis Peptidyl Arginine Deiminase (PPAD) in the Context of the Feed-Forward Loop of Inflammation in Periodontitis.
Prucsi Z, Zimny A, Płonczyńska A, Zubrzycka N, Potempa J, Sochalska M
International journal of molecular sciences 2023 Aug 18;24(16)
International journal of molecular sciences 2023 Aug 18;24(16)
MCL-1 is a master regulator of cancer dependency on fatty acid oxidation.
Prew MS, Adhikary U, Choi DW, Portero EP, Paulo JA, Gowda P, Budhraja A, Opferman JT, Gygi SP, Danial NN, Walensky LD
Cell reports 2022 Oct 4;41(1):111445
Cell reports 2022 Oct 4;41(1):111445
Ca(2+)-mediated mitochondrial inner membrane permeabilization induces cell death independently of Bax and Bak.
Quarato G, Llambi F, Guy CS, Min J, Actis M, Sun H, Narina S, Pruett-Miller SM, Peng J, Rankovic Z, Green DR
Cell death and differentiation 2022 Jul;29(7):1318-1334
Cell death and differentiation 2022 Jul;29(7):1318-1334
Mcl-1 Differentially Regulates Autophagy in Response to Changes in Energy Status and Mitochondrial Damage.
Moyzis AG, Lally NS, Liang W, Najor RH, Gustafsson ÅB
Cells 2022 Apr 27;11(9)
Cells 2022 Apr 27;11(9)
Inhibition of the Anti-Apoptotic Bcl-2 Family by BH3 Mimetics Sensitize the Mitochondrial Permeability Transition Pore Through Bax and Bak.
Patel P, Mendoza A, Robichaux DJ, Wang MC, Wehrens XHT, Karch J
Frontiers in cell and developmental biology 2021;9:765973
Frontiers in cell and developmental biology 2021;9:765973
The Role of Mcl-1 in Embryonic Neural Precursor Cell Apoptosis.
Flemmer RT, Connolly SP, Geizer BA, Opferman JT, Vanderluit JL
Frontiers in cell and developmental biology 2021;9:659531
Frontiers in cell and developmental biology 2021;9:659531
p53-Independent Induction of p21 Fails to Control Regeneration and Hepatocarcinogenesis in a Murine Liver Injury Model.
Buitrago-Molina LE, Marhenke S, Becker D, Geffers R, Itzel T, Teufel A, Jaeschke H, Lechel A, Unger K, Markovic J, Sharma AD, Marquardt JU, Saborowski M, Saborowski A, Vogel A
Cellular and molecular gastroenterology and hepatology 2021;11(5):1387-1404
Cellular and molecular gastroenterology and hepatology 2021;11(5):1387-1404
Ser9 phosphorylation of GSK-3β promotes aging in the heart through suppression of autophagy.
Chen Y, Maejima Y, Shirakabe A, Yamamoto T, Ikeda Y, Sadoshima J, Zhai P
The journal of cardiovascular aging 2021;1
The journal of cardiovascular aging 2021;1
Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis, and tumorigenesis.
Mizutani N, Hikita H, Saito Y, Myojin Y, Sato K, Urabe M, Kurahashi T, Shiode Y, Sakane S, Murai K, Nozaki Y, Kodama T, Sakamori R, Yoshida Y, Tatsumi T, Takehara T
American journal of physiology. Gastrointestinal and liver physiology 2021 Jun 1;320(6):G958-G968
American journal of physiology. Gastrointestinal and liver physiology 2021 Jun 1;320(6):G958-G968
Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation.
Sumiyoshi M, Kotani Y, Ikuta Y, Suzue K, Ozawa M, Katakai T, Yamada T, Abe T, Bando K, Koyasu S, Kanaho Y, Watanabe T, Matsuda S
Journal of immunology (Baltimore, Md. : 1950) 2021 Jan 15;206(2):366-375
Journal of immunology (Baltimore, Md. : 1950) 2021 Jan 15;206(2):366-375
The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics.
Smith KH, Budhraja A, Lynch J, Roberts K, Panetta JC, Connelly JP, Turnis ME, Pruett-Miller SM, Schuetz JD, Mullighan CG, Opferman JT
Molecular cancer research : MCR 2021 Apr;19(4):636-650
Molecular cancer research : MCR 2021 Apr;19(4):636-650
Requirement for antiapoptotic MCL-1 during early erythropoiesis.
Turnis ME, Kaminska E, Smith KH, Kartchner BJ, Vogel P, Laxton JD, Ashmun RA, Ney PA, Opferman JT
Blood 2021 Apr 8;137(14):1945-1958
Blood 2021 Apr 8;137(14):1945-1958
Mcl-1-mediated mitochondrial fission protects against stress but impairs cardiac adaptation to exercise.
Moyzis AG, Lally NS, Liang W, Leon LJ, Najor RH, Orogo AM, Gustafsson ÅB
Journal of molecular and cellular cardiology 2020 Sep;146:109-120
Journal of molecular and cellular cardiology 2020 Sep;146:109-120
Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1.
Dong L, Vaux DL
Cell death & disease 2020 Jun 8;11(6):442
Cell death & disease 2020 Jun 8;11(6):442
Hepatocyte apoptosis is tumor promoting in murine nonalcoholic steatohepatitis.
Hirsova P, Bohm F, Dohnalkova E, Nozickova B, Heikenwalder M, Gores GJ, Weber A
Cell death & disease 2020 Feb 3;11(2):80
Cell death & disease 2020 Feb 3;11(2):80
Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.
Jayavelu AK, Schnöder TM, Perner F, Herzog C, Meiler A, Krishnamoorthy G, Huber N, Mohr J, Edelmann-Stephan B, Austin R, Brandt S, Palandri F, Schröder N, Isermann B, Edlich F, Sinha AU, Ungelenk M, Hübner CA, Zeiser R, Rahmig S, Waskow C, Coldham I, Ernst T, Hochhaus A, Jilg S, Jost PJ, Mullally A, Bullinger L, Mertens PR, Lane SW, Mann M, Heidel FH
Nature 2020 Dec;588(7836):157-163
Nature 2020 Dec;588(7836):157-163
MCL-1 is essential for survival but dispensable for metabolic fitness of FOXP3(+) regulatory T cells.
Teh CE, Robbins AK, Henstridge DC, Dewson G, Diepstraten ST, Kelly G, Febbraio MA, Gabriel SS, O'Reilly LA, Strasser A, Gray DHD
Cell death and differentiation 2020 Dec;27(12):3374-3385
Cell death and differentiation 2020 Dec;27(12):3374-3385
MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex.
Djajawi TM, Liu L, Gong JN, Huang AS, Luo MJ, Xu Z, Okamoto T, Call MJ, Huang DCS, van Delft MF
Cell death and differentiation 2020 Aug;27(8):2484-2499
Cell death and differentiation 2020 Aug;27(8):2484-2499
In the absence of apoptosis, myeloid cells arrest when deprived of growth factor, but remain viable by consuming extracellular glucose.
Dong L, Reljic B, Cheung JG, Ng ES, Lindqvist LM, Elefanty AG, Vaux DL, Tran H
Cell death and differentiation 2019 Oct;26(10):2074-2085
Cell death and differentiation 2019 Oct;26(10):2074-2085
Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis.
Wang S, Ni HM, Chao X, Wang H, Bridges B, Kumer S, Schmitt T, Mareninova O, Gukovskaya A, De Lisle RC, Ballabio A, Pacher P, Ding WX
Autophagy 2019 Nov;15(11):1954-1969
Autophagy 2019 Nov;15(11):1954-1969
DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-β signaling pathway.
Saito Y, Hikita H, Nozaki Y, Kai Y, Makino Y, Nakabori T, Tanaka S, Yamada R, Shigekawa M, Kodama T, Sakamori R, Tatsumi T, Takehara T
Cell death and differentiation 2019 Mar;26(3):470-486
Cell death and differentiation 2019 Mar;26(3):470-486
CHK1 dosage in germinal center B cells controls humoral immunity.
Schoeler K, Jakic B, Heppke J, Soratroi C, Aufschnaiter A, Hermann-Kleiter N, Villunger A, Labi V
Cell death and differentiation 2019 Dec;26(12):2551-2567
Cell death and differentiation 2019 Dec;26(12):2551-2567
The AKT isoforms 1 and 2 drive B cell fate decisions during the germinal center response.
Zhu Z, Shukla A, Ramezani-Rad P, Apgar JR, Rickert RC
Life science alliance 2019 Dec;2(6)
Life science alliance 2019 Dec;2(6)
Mcl-1 and Bcl-xL are essential for survival of the developing nervous system.
Fogarty LC, Flemmer RT, Geizer BA, Licursi M, Karunanithy A, Opferman JT, Hirasawa K, Vanderluit JL
Cell death and differentiation 2019 Aug;26(8):1501-1515
Cell death and differentiation 2019 Aug;26(8):1501-1515
Infection with flaviviruses requires BCLXL for cell survival.
Suzuki T, Okamoto T, Katoh H, Sugiyama Y, Kusakabe S, Tokunaga M, Hirano J, Miyata Y, Fukuhara T, Ikawa M, Satoh T, Yoshio S, Suzuki R, Saijo M, Huang DCS, Kanto T, Akira S, Matsuura Y
PLoS pathogens 2018 Sep;14(9):e1007299
PLoS pathogens 2018 Sep;14(9):e1007299
Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer.
Guerra RM, Bird GH, Harvey EP, Dharia NV, Korshavn KJ, Prew MS, Stegmaier K, Walensky LD
Cell reports 2018 Sep 25;24(13):3393-3403.e5
Cell reports 2018 Sep 25;24(13):3393-3403.e5
Requirement of GSK-3 for PUMA induction upon loss of pro-survival PI3K signaling.
Schubert F, Rapp J, Brauns-Schubert P, Schlicher L, Stock K, Wissler M, Weiß M, Charvet C, Borner C, Maurer U
Cell death & disease 2018 May 1;9(5):470
Cell death & disease 2018 May 1;9(5):470
Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD.
Escudero S, Zaganjor E, Lee S, Mill CP, Morgan AM, Crawford EB, Chen J, Wales TE, Mourtada R, Luccarelli J, Bird GH, Steidl U, Engen JR, Haigis MC, Opferman JT, Walensky LD
Molecular cell 2018 Mar 1;69(5):729-743.e7
Molecular cell 2018 Mar 1;69(5):729-743.e7
Differential effects of Vav-promoter-driven overexpression of BCLX and BFL1 on lymphocyte survival and B cell lymphomagenesis.
Tuzlak S, Haschka MD, Mokina AM, Rülicke T, Cory S, Labi V, Villunger A
The FEBS journal 2018 Apr;285(8):1403-1418
The FEBS journal 2018 Apr;285(8):1403-1418
Dynein light chain 1 induces assembly of large Bim complexes on mitochondria that stabilize Mcl-1 and regulate apoptosis.
Singh PK, Roukounakis A, Frank DO, Kirschnek S, Das KK, Neumann S, Madl J, Römer W, Zorzin C, Borner C, Haimovici A, Garcia-Saez A, Weber A, Häcker G
Genes & development 2017 Sep 1;31(17):1754-1769
Genes & development 2017 Sep 1;31(17):1754-1769
Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.
Brouwer JM, Lan P, Cowan AD, Bernardini JP, Birkinshaw RW, van Delft MF, Sleebs BE, Robin AY, Wardak A, Tan IK, Reljic B, Lee EF, Fairlie WD, Call MJ, Smith BJ, Dewson G, Lessene G, Colman PM, Czabotar PE
Molecular cell 2017 Nov 16;68(4):659-672.e9
Molecular cell 2017 Nov 16;68(4):659-672.e9
JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins.
Girnius N, Davis RJ
Cell reports 2017 Nov 14;21(7):1910-1921
Cell reports 2017 Nov 14;21(7):1910-1921
The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.
Tuzlak S, Schenk RL, Vasanthakumar A, Preston SP, Haschka MD, Zotos D, Kallies A, Strasser A, Villunger A, Herold MJ
Cell death and differentiation 2017 Mar;24(3):523-533
Cell death and differentiation 2017 Mar;24(3):523-533
Post-translational control of T cell development by the ESCRT protein CHMP5.
Adoro S, Park KH, Bettigole SE, Lis R, Shin HR, Seo H, Kim JH, Knobeloch KP, Shim JH, Glimcher LH
Nature immunology 2017 Jul;18(7):780-790
Nature immunology 2017 Jul;18(7):780-790
MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis.
Sochalska M, Schuler F, Weiss JG, Prchal-Murphy M, Sexl V, Villunger A
Oncogene 2017 Apr;36(15):2066-2073
Oncogene 2017 Apr;36(15):2066-2073
Corrigendum: Distinct Transcriptomic Features Are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen.
Kleiman E, Salyakina D, De Heusch M, Hoek KL, Llanes JM, Castro I, Wright JA, Clark ES, Dykxhoorn DM, Capobianco E, Takeda A, McCormack RM, Podack ER, Renauld JC, Khan WN
Frontiers in immunology 2016;7:267
Frontiers in immunology 2016;7:267
Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins.
Goodall KJ, Finch-Edmondson ML, van Vuuren J, Yeoh GC, Gentle IE, Vince JE, Ekert PG, Vaux DL, Callus BA
PloS one 2016;11(11):e0164003
PloS one 2016;11(11):e0164003
Structure-function insights reveal the human ribosome as a cancer target for antibiotics.
Myasnikov AG, Kundhavai Natchiar S, Nebout M, Hazemann I, Imbert V, Khatter H, Peyron JF, Klaholz BP
Nature communications 2016 Sep 26;7:12856
Nature communications 2016 Sep 26;7:12856
Allosteric inhibition of antiapoptotic MCL-1.
Lee S, Wales TE, Escudero S, Cohen DT, Luccarelli J, Gallagher CG, Cohen NA, Huhn AJ, Bird GH, Engen JR, Walensky LD
Nature structural & molecular biology 2016 Jun;23(6):600-7
Nature structural & molecular biology 2016 Jun;23(6):600-7
The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland.
Schuler F, Baumgartner F, Klepsch V, Chamson M, Müller-Holzner E, Watson CJ, Oh S, Hennighausen L, Tymoszuk P, Doppler W, Villunger A
Cell death and differentiation 2016 Jan;23(1):41-51
Cell death and differentiation 2016 Jan;23(1):41-51
Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response.
Thornton TM, Delgado P, Chen L, Salas B, Krementsov D, Fernandez M, Vernia S, Davis RJ, Heimann R, Teuscher C, Krangel MS, Ramiro AR, Rincón M
Nature communications 2016 Jan 29;7:10553
Nature communications 2016 Jan 29;7:10553
The anti-apoptotic Bcl-2 family protein A1/Bfl-1 regulates neutrophil survival and homeostasis and is controlled via PI3K and JAK/STAT signaling.
Vier J, Groth M, Sochalska M, Kirschnek S
Cell death & disease 2016 Feb 18;7(2):e2103
Cell death & disease 2016 Feb 18;7(2):e2103
Anti-apoptotic Bcl-XL but not Mcl-1 contributes to protection against virus-induced apoptosis.
Ohmer M, Weber A, Sutter G, Ehrhardt K, Zimmermann A, Häcker G
Cell death & disease 2016 Aug 18;7(8):e2340
Cell death & disease 2016 Aug 18;7(8):e2340
Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.
Sochalska M, Ottina E, Tuzlak S, Herzog S, Herold M, Villunger A
Cell death and differentiation 2016 Apr;23(4):628-39
Cell death and differentiation 2016 Apr;23(4):628-39
Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury.
Wang S, Ni HM, Dorko K, Kumer SC, Schmitt TM, Nawabi A, Komatsu M, Huang H, Ding WX
Oncotarget 2016 Apr 5;7(14):17681-98
Oncotarget 2016 Apr 5;7(14):17681-98
Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury.
D'Orsi B, Engel T, Pfeiffer S, Nandi S, Kaufmann T, Henshall DC, Prehn JH
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Apr 20;36(16):4564-78
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Apr 20;36(16):4564-78
An interconnected hierarchical model of cell death regulation by the BCL-2 family.
Chen HC, Kanai M, Inoue-Yamauchi A, Tu HC, Huang Y, Ren D, Kim H, Takeda S, Reyna DE, Chan PM, Ganesan YT, Liao CP, Gavathiotis E, Hsieh JJ, Cheng EH
Nature cell biology 2015 Oct;17(10):1270-81
Nature cell biology 2015 Oct;17(10):1270-81
Mcl-1 is a key regulator of the ovarian reserve.
Omari S, Waters M, Naranian T, Kim K, Perumalsamy AL, Chi M, Greenblatt E, Moley KH, Opferman JT, Jurisicova A
Cell death & disease 2015 May 7;6(5):e1755
Cell death & disease 2015 May 7;6(5):e1755
Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics.
Choudhary GS, Tat TT, Misra S, Hill BT, Smith MR, Almasan A, Mazumder S
Oncotarget 2015 Jul 10;6(19):16912-25
Oncotarget 2015 Jul 10;6(19):16912-25
Chronic Deletion and Acute Knockdown of Parkin Have Differential Responses to Acetaminophen-induced Mitophagy and Liver Injury in Mice.
Williams JA, Ni HM, Haynes A, Manley S, Li Y, Jaeschke H, Ding WX
The Journal of biological chemistry 2015 Apr 24;290(17):10934-46
The Journal of biological chemistry 2015 Apr 24;290(17):10934-46
BH3-only protein BIM mediates heat shock-induced apoptosis.
Mahajan IM, Chen MD, Muro I, Robertson JD, Wright CW, Bratton SB
PloS one 2014;9(1):e84388
PloS one 2014;9(1):e84388
HTLV-1 tax stabilizes MCL-1 via TRAF6-dependent K63-linked polyubiquitination to promote cell survival and transformation.
Choi YB, Harhaj EW
PLoS pathogens 2014 Oct;10(10):e1004458
PLoS pathogens 2014 Oct;10(10):e1004458
Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function.
Ma SB, Nguyen TN, Tan I, Ninnis R, Iyer S, Stroud DA, Menard M, Kluck RM, Ryan MT, Dewson G
Cell death and differentiation 2014 Dec;21(12):1925-35
Cell death and differentiation 2014 Dec;21(12):1925-35
RAF and antioxidants prevent cell death induction after growth factor abrogation through regulation of Bcl-2 proteins.
Koziel K, Smigelskaite J, Drasche A, Enthammer M, Ashraf MI, Khalid S, Troppmair J
Experimental cell research 2013 Oct 15;319(17):2728-38
Experimental cell research 2013 Oct 15;319(17):2728-38
Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1.
Rutherford C, Childs S, Ohotski J, McGlynn L, Riddick M, MacFarlane S, Tasker D, Pyne S, Pyne NJ, Edwards J, Palmer TM
Cell death & disease 2013 Nov 21;4(11):e927
Cell death & disease 2013 Nov 21;4(11):e927
Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure.
Thomas RL, Roberts DJ, Kubli DA, Lee Y, Quinsay MN, Owens JB, Fischer KM, Sussman MA, Miyamoto S, Gustafsson ÅB
Genes & development 2013 Jun 15;27(12):1365-77
Genes & development 2013 Jun 15;27(12):1365-77
Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons.
Magiera MM, Mora S, Mojsa B, Robbins I, Lassot I, Desagher S
Cell death and differentiation 2013 Feb;20(2):281-92
Cell death and differentiation 2013 Feb;20(2):281-92
Mcl1 regulates the terminal mitosis of neural precursor cells in the mammalian brain through p27Kip1.
Hasan SM, Sheen AD, Power AM, Langevin LM, Xiong J, Furlong M, Day K, Schuurmans C, Opferman JT, Vanderluit JL
Development (Cambridge, England) 2013 Aug;140(15):3118-27
Development (Cambridge, England) 2013 Aug;140(15):3118-27
Obesity promotes liver carcinogenesis via Mcl-1 stabilization independent of IL-6Rα signaling.
Gruber S, Straub BK, Ackermann PJ, Wunderlich CM, Mauer J, Seeger JM, Büning H, Heukamp L, Kashkar H, Schirmacher P, Brüning JC, Wunderlich FT
Cell reports 2013 Aug 29;4(4):669-80
Cell reports 2013 Aug 29;4(4):669-80
Oncogenic kit triggers Shp2/Erk1/2 pathway to down-regulate the pro-apoptotic protein Bim and to promote apoptosis resistance in leukemic cells.
Selimoglu-Buet D, Gallais I, Denis N, Guillouf C, Moreau-Gachelin F
PloS one 2012;7(11):e49052
PloS one 2012;7(11):e49052
miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes.
Ouyang YB, Lu Y, Yue S, Giffard RG
Mitochondrion 2012 Mar;12(2):213-9
Mitochondrion 2012 Mar;12(2):213-9
Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo.
Clybouw C, Merino D, Nebl T, Masson F, Robati M, O'Reilly L, Hübner A, Davis RJ, Strasser A, Bouillet P
Cell death and differentiation 2012 Jun;19(6):1060-8
Cell death and differentiation 2012 Jun;19(6):1060-8
Mcl-1 regulates the survival of adult neural precursor cells.
Malone CD, Hasan SM, Roome RB, Xiong J, Furlong M, Opferman JT, Vanderluit JL
Molecular and cellular neurosciences 2012 Apr;49(4):439-47
Molecular and cellular neurosciences 2012 Apr;49(4):439-47
A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).
Mavrakis KJ, Van Der Meulen J, Wolfe AL, Liu X, Mets E, Taghon T, Khan AA, Setty M, Rondou P, Vandenberghe P, Delabesse E, Benoit Y, Socci NB, Leslie CS, Van Vlierberghe P, Speleman F, Wendel HG
Nature genetics 2011 Jun 5;43(7):673-8
Nature genetics 2011 Jun 5;43(7):673-8
BH3 domains other than Bim and Bid can directly activate Bax/Bak.
Du H, Wolf J, Schafer B, Moldoveanu T, Chipuk JE, Kuwana T
The Journal of biological chemistry 2011 Jan 7;286(1):491-501
The Journal of biological chemistry 2011 Jan 7;286(1):491-501
In vivo activity of combined PI3K/mTOR and MEK inhibition in a Kras(G12D);Pten deletion mouse model of ovarian cancer.
Kinross KM, Brown DV, Kleinschmidt M, Jackson S, Christensen J, Cullinane C, Hicks RJ, Johnstone RW, McArthur GA
Molecular cancer therapeutics 2011 Aug;10(8):1440-9
Molecular cancer therapeutics 2011 Aug;10(8):1440-9
c-Myb promotes the survival of CD4+CD8+ double-positive thymocytes through upregulation of Bcl-xL.
Yuan J, Crittenden RB, Bender TP
Journal of immunology (Baltimore, Md. : 1950) 2010 Mar 15;184(6):2793-804
Journal of immunology (Baltimore, Md. : 1950) 2010 Mar 15;184(6):2793-804
Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development.
Malin S, McManus S, Cobaleda C, Novatchkova M, Delogu A, Bouillet P, Strasser A, Busslinger M
Nature immunology 2010 Feb;11(2):171-9
Nature immunology 2010 Feb;11(2):171-9
Mitophagy in mammalian cells: the reticulocyte model.
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Methods in enzymology 2009;452:227-45
Methods in enzymology 2009;452:227-45
Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver.
Hikita H, Takehara T, Shimizu S, Kodama T, Li W, Miyagi T, Hosui A, Ishida H, Ohkawa K, Kanto T, Hiramatsu N, Yin XM, Hennighausen L, Tatsumi T, Hayashi N
Hepatology (Baltimore, Md.) 2009 Oct;50(4):1217-26
Hepatology (Baltimore, Md.) 2009 Oct;50(4):1217-26
Mcl-1 degradation during hepatocyte lipoapoptosis.
Masuoka HC, Mott J, Bronk SF, Werneburg NW, Akazawa Y, Kaufmann SH, Gores GJ
The Journal of biological chemistry 2009 Oct 30;284(44):30039-48
The Journal of biological chemistry 2009 Oct 30;284(44):30039-48
Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors.
Whitecross KF, Alsop AE, Cluse LA, Wiegmans A, Banks KM, Coomans C, Peart MJ, Newbold A, Lindemann RK, Johnstone RW
Blood 2009 Feb 26;113(9):1982-91
Blood 2009 Feb 26;113(9):1982-91
BH3-only protein bid participates in the Bcl-2 network in healthy liver cells.
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Hepatology (Baltimore, Md.) 2009 Dec;50(6):1972-80
Hepatology (Baltimore, Md.) 2009 Dec;50(6):1972-80
The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages.
Dzhagalov I, Dunkle A, He YW
Journal of immunology (Baltimore, Md. : 1950) 2008 Jul 1;181(1):521-8
Journal of immunology (Baltimore, Md. : 1950) 2008 Jul 1;181(1):521-8
Triggering of apoptosis by Puma is determined by the threshold set by prosurvival Bcl-2 family proteins.
Callus BA, Moujallad DM, Silke J, Gerl R, Jabbour AM, Ekert PG, Vaux DL
Journal of molecular biology 2008 Dec 12;384(2):313-23
Journal of molecular biology 2008 Dec 12;384(2):313-23
NIX is required for programmed mitochondrial clearance during reticulocyte maturation.
Schweers RL, Zhang J, Randall MS, Loyd MR, Li W, Dorsey FC, Kundu M, Opferman JT, Cleveland JL, Miller JL, Ney PA
Proceedings of the National Academy of Sciences of the United States of America 2007 Dec 4;104(49):19500-5
Proceedings of the National Academy of Sciences of the United States of America 2007 Dec 4;104(49):19500-5
Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion.
Deng J, Shimamura T, Perera S, Carlson NE, Cai D, Shapiro GI, Wong KK, Letai A
Cancer research 2007 Dec 15;67(24):11867-75
Cancer research 2007 Dec 15;67(24):11867-75
Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.
Huntington ND, Puthalakath H, Gunn P, Naik E, Michalak EM, Smyth MJ, Tabarias H, Degli-Esposti MA, Dewson G, Willis SN, Motoyama N, Huang DC, Nutt SL, Tarlinton DM, Strasser A
Nature immunology 2007 Aug;8(8):856-63
Nature immunology 2007 Aug;8(8):856-63
Dominant negative retinoic acid receptor initiates tumor formation in mice.
Kupumbati TS, Cattoretti G, Marzan C, Farias EF, Taneja R, Mira-y-Lopez R
Molecular cancer 2006 Mar 24;5:12
Molecular cancer 2006 Mar 24;5:12
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Supportive validation
- Submitted by
- Rockland Immunochemicals, Inc. (provider)
- Main image
- Experimental details
- Western blot analysis using Rockland Immuno-chemical's anti-Mcl-1 antibody to detect Mcl-1 in MEF cell lysates (20 µg per lane). Anti-Mcl-1 was used at a dilution of 1:10,000 followed by reaction with HRP Anti-Rabbit IgG [H&L] MX10 (GOAT) used at a 1:2,000 dilution. Western Lightning Chemiluminescence Reagent Plus from Perkin Elmer was used for detection. The exposure time was exactly 30 seconds. This antibody detects 35 kDa mouse Mcl-1. Communicated with permission by J. Opferman and S. Korsmeyer. See Opferman et al (2003) for additional details.
- Validation comment
- Western Blot
