66338-1-Ig

antibody from Proteintech Group

Targeting: MMP3 STMY, STMY1

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66338-1-Ig

Provider

Proteintech Group

Product name

MMP3 antibody

Antibody type

Monoclonal

Description

KD/KO validated MMP3 antibody (Cat. #66338-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, rat, mouse, pig and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat, Porcine

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

1F5A9

Vial size

20ul, 150ul

References

Submitted references

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RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats' intervertebral disc degeneration.

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Hua Zheng San Ji Fang suppresses liver cancer progression by inhibiting TYRO3 expression via the ERK signaling pathway.

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Developmental Regulation of Matrix Metalloproteinases in Response to Multifactorial, Severe Traumatic Brain Injuries during Immaturity.

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Licoricesaponin G2 ameliorates bleomycin-induced pulmonary fibrosis via targeting TNF-α signaling pathway and inhibiting the epithelial-mesenchymal transition.

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British journal of cancer 2024 Sep;131(4):655-667

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Trifarotene alleviates skin photoaging injury by inhibition of JNK/c-Jun/MMPs.

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Taurine rescues intervertebral disc degeneration by activating mitophagy through the PINK1/Parkin pathway.

Lin S, Li T, Zhang B, Wang P
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Zhao X, Wang T, Li N, Meng Z, Wang W, Wang B, Song D
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Inflammatory Fibroblast-Like Synoviocyte-Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis.

Liu B, Xian Y, Chen X, Shi Y, Dong J, Yang L, An X, Shen T, Wu W, Ma Y, He Y, Gong W, Peng R, Lin J, Liu N, Guo B, Jiang Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2307338

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Identification of gene signatures associated with ulcerative colitis and the association with immune infiltrates in colon cancer.

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METTL3 promotes SMSCs chondrogenic differentiation by targeting the MMP3, MMP13, and GATA3.

Hu B, Zou X, Yu Y, Jiang Y, Xu H
Regenerative therapy 2023 Mar;22:148-159

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Low-dose celecoxib-loaded PCL fibers reverse intervertebral disc degeneration by up-regulating CHSY3 expression.

Wang Y, Zheng G, Xie X, Yu W, Wang J, Zang F, Yang C, Xiao Q, Zhang R, Wei L, Wu X, Liang L, Cao P, Xu C, Li J, Hu B, Zhang T, Wu J, Chen H
Journal of nanobiotechnology 2023 Mar 3;21(1):76

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Sacha inchi albumin delays skin-aging by alleviating inflammation, oxidative stress and regulating gut microbiota in d-galactose induced-aging mice.

Zeng J, An M, Tian W, Wang K, Du B, Li P
Journal of the science of food and agriculture 2023 Jul;103(9):4470-4480

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Cellular-scale sex differences in extracellular matrix remodeling by valvular interstitial cells.

Simon LR, Scott AJ, Figueroa Rios L, Zembles J, Masters KS
Heart and vessels 2023 Jan;38(1):122-130

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RARγ promotes the invasion and metastasis of thyroid carcinoma by activating the JAK1-STAT3-CD24/MMPs axis.

Zhang FX, Xu P, Zhang LJ, Fan R, Zhang HX, Liu DH, Liu K, Shen DY
International immunopharmacology 2023 Dec;125(Pt A):111129

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Monotropein attenuates apoptosis and pyroptosis in chondrocytes and alleviates osteoarthritis progression in mice.

Li Z, Chen Z, Chen J, Liu Z, Li Z, Sun H, Wang X, Wei J, Cao X, Zheng D
Chinese medicine 2023 Apr 19;18(1):42

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ALPK1 Accelerates the Pathogenesis of Osteoarthritis by Activating NLRP3 Signaling.

Liu X, Zhao J, Jiang H, Guo H, Li Y, Li H, Feng Y, Ke J, Long X
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Oct;37(10):1973-1985

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Role of ROR2 in promoting gastric cancer metastasis by enhancing c-JUN-mediated MMP3 transcription.

Ge X, Lin F, Wu Z, Lin Y, Tang W, McKay MJ, Sahu A, Lino-Silva LS, Tseng J, Li J
Annals of translational medicine 2022 Oct;10(20):1117

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Caffeic acid phenethyl ester attenuates osteoarthritis progression by activating NRF2/HO‑1 and inhibiting the NF‑κB signaling pathway.

Sun W, Xie W, Huang D, Cui Y, Yue J, He Q, Jiang L, Xiong J, Sun W, Yi Q
International journal of molecular medicine 2022 Nov;50(5)

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Gaseous signal molecule SO(2) regulates autophagy through PI3K/AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes.

Zhao J, Wu Q, Yang T, Nie L, Liu S, Zhou J, Chen J, Jiang Z, Xiao T, Yang J, Chu C
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2022 Nov 1;26(6):541-556

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Single-cell RNA sequencing reveals the cell types heterogenicity of human discoid lateral meniscus cells.

Sun H, Zhang W, Liu F, Li D, Cai Z, Huang Z, Chen M, Lin Z, Xu J, Ma R
Journal of cellular physiology 2022 May;237(5):2469-2477

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Allergy-induced systemic inflammation impairs tendon quality.

Lehner C, Spitzer G, Langthaler P, Jakubecova D, Klein B, Weissenbacher N, Wagner A, Gehwolf R, Trinka E, Iglseder B, Paulweber B, Aigner L, Couillard-Després S, Weiss R, Tempfer H, Traweger A
EBioMedicine 2022 Jan;75:103778

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Methylene blue prevents osteoarthritis progression and relieves pain in rats via upregulation of Nrf2/PRDX1.

Li JW, Wang RL, Xu J, Sun KY, Jiang HM, Sun ZY, Lv ZY, Xu XQ, Wu R, Guo H, Jiang Q, Shi DQ
Acta pharmacologica Sinica 2022 Feb;43(2):417-428

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Glycyrrhizin regulates rat TMJOA progression by inhibiting the HMGB1-RAGE/TLR4-NF-κB/AKT pathway.

Hu Z, Xiao M, Cai H, Li W, Fang W, Long X
Journal of cellular and molecular medicine 2022 Feb;26(3):925-936

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Reducing Inflammation and Vascular Invasion in Intervertebral Disc Degeneration via Cystathionine-γ-Lyase Inhibitory Effect on E-Selectin.

Xu H, Wei K, Tu J, Chen Y, He Y, Ding Y, Xu H, Bao X, Xie H, Fang H, Wang H
Frontiers in cell and developmental biology 2021;9:741046

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Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect.

Lu R, Yu X, Liang S, Cheng P, Wang Z, He ZY, Lv ZT, Wan J, Mo H, Zhu WT, Chen AM
Frontiers in pharmacology 2021;12:761922

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Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis.

Pei W, Huang X, Ni B, Zhang R, Niu G, You H
Frontiers in pharmacology 2021;12:730312

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Therapeutic effect of neohesperidin on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes.

Wang XH, Dai C, Wang J, Liu R, Li L, Yin ZS
Chinese journal of natural medicines 2021 Oct;19(10):741-749

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High fibular osteotomy ameliorates medial compartment knee osteoarthritis in a rabbit model.

Yan F, Zhao X, Duan S, Maimaiti A, Qi Y, Li M, Maimaiti M, Li W
Journal of biomechanics 2021 Nov 9;128:110734

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Zonal-Layered Chondrocyte Sheets for Repairment of Full-Thickness Articular Cartilage Defect: A Mini-Pig Model.

Shen PC, Lu CC, Chou SH, Liu ZM, Su SJ, Tien YC
Biomedicines 2021 Nov 30;9(12)

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17β-Estradiol alleviates intervertebral disc degeneration by inhibiting NF-κB signal pathway.

Wang H, Li Z, Huo Y, Tian T, Yang D, Ma L, Yang S, Ding W
Life sciences 2021 Nov 1;284:119874

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Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration.

Guo Z, Qiu C, Mecca C, Zhang Y, Bian J, Wang Y, Wu X, Wang T, Su W, Li X, Zhang W, Chen B, Xiang H
BMC musculoskeletal disorders 2021 Jan 13;22(1):77

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Matrix metalloproteinase 3 regulates angiotensin II‑induced myocardial fibrosis cell viability, migration and apoptosis.

Shu J, Gu Y, Jin L, Wang H
Molecular medicine reports 2021 Feb;23(2)

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Scleraxis expressing scleral cells respond to inflammatory stimulation.

Atta G, Schroedl F, Kaser-Eichberger A, Spitzer G, Traweger A, Heindl LM, Tempfer H
Histochemistry and cell biology 2021 Aug;156(2):123-132

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Effects of HDAC4 on IL-1β-induced matrix metalloproteinase expression regulated partially through the WNT3A/β-catenin pathway.

Ning Q, Gan YH, Shi RR, Meng JH
Chinese medical journal 2021 Apr 8;134(8):963-970

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ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration.

Ding J, Zhang R, Li H, Ji Q, Cheng X, Thorne RF, Hondermarck H, Liu X, Shen C
Aging 2021 Apr 6;13(7):10703-10723

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Oxymatrine Liposomes for Intervertebral Disc Treatment: Formulation, in vitro and vivo Assessments.

Wang H, Ding Y, Zhang W, Wei K, Pei Y, Zou C, Zhang C, Ding J, Fang H, Tan S
Drug design, development and therapy 2020;14:921-931

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TLR4 contributes to the damage of cartilage and subchondral bone in discectomy-induced TMJOA mice.

Liu X, Cai HX, Cao PY, Feng Y, Jiang HH, Liu L, Ke J, Long X
Journal of cellular and molecular medicine 2020 Oct;24(19):11489-11499

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Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway.

Wei K, Dai J, Wang Z, Pei Y, Chen Y, Ding Y, Ding Q, Ahati P, Zhou X, Wang H, Fang H
Experimental biology and medicine (Maywood, N.J.) 2020 Mar;245(6):532-541

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Long non-coding RNA lnc-DC in dendritic cells regulates trophoblast invasion via p-STAT3-mediated TIMP/MMP expression.

Zhang W, Yang M, Yu L, Hu Y, Deng Y, Liu Y, Xiao S, Ding Y
American journal of reproductive immunology (New York, N.Y. : 1989) 2020 Jun;83(6):e13239

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Macromechanics and polycaprolactone fiber organization drive macrophage polarization and regulate inflammatory activation of tendon in vitro and in vivo.

Schoenenberger AD, Tempfer H, Lehner C, Egloff J, Mauracher M, Bird A, Widmer J, Maniura-Weber K, Fucentese SF, Traweger A, Silvan U, Snedeker JG
Biomaterials 2020 Aug;249:120034

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Stromal cell‑derived factor‑1 induces matrix metalloproteinase expression in human endplate chondrocytes, cartilage endplate degradation in explant culture, and the amelioration of nucleus pulposus degeneration in vivo.

Zhang H, Zhu T, Zhang L, Wu Q
International journal of molecular medicine 2018 Feb;41(2):969-976

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Iron overload in a murine model of hereditary hemochromatosis is associated with accelerated progression of osteoarthritis under mechanical stress.

Camacho A, Simão M, Ea HK, Cohen-Solal M, Richette P, Branco J, Cancela ML
Osteoarthritis and cartilage 2016 Mar;24(3):494-502