ADGRG1

This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Description

Adhesion G protein-coupled receptor G1

Tissue specificity

Tissue enhanced (thyroid gland)

Predicted location

Intracellular, Membrane, Secreted to blood

Protein family

Disease related genes
G-protein coupled receptors
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

16:q21 (57610652 - 57665580)

Ensembl ID

ENSG00000205336  (ver. 103.38)

Orthologs

Mouse Adgrg1: ENSMUSG00000031785

UniProt

Q9Y653

neXtProt

NX_Q9Y653

Human splice variants
Mouse splice variants