CHRNB4

This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]

Description

Cholinergic receptor nicotinic beta 4 subunit

Tissue specificity

Tissue enhanced (lymphoid tissue, retina, testis)

Subcell location

Endoplasmic reticulum, Cell Junctions

Predicted location

Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

15 (78624111 - 78727754)

Ensembl ID

ENSG00000117971  (ver. 103.38)

Orthologs

Mouse Chrnb4: ENSMUSG00000035200

UniProt

P30926

neXtProt

NX_P30926

Human splice variants
Mouse splice variants

Protein structure