16645-1-AP

antibody from Proteintech Group

Targeting: ASL ASAL

Provider product page for 16645-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [14]
Comments [0]
Validations
Western blot [1]

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Product number: 16645-1-AP - Provider product page
Provider: Proteintech Group
Product name: ASL antibody
Antibody type: Polyclonal
Description: ASL antibody (Cat. #16645-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ASL protein structure - 16645-1-AP shown in red.

Submitted references Microglial GLUL loss worsens TBI outcomes by amplifying the arginine-citrulline pathway.

Li J, Zhao Y, Yang Y, Dai Q, Tian R, Wang J, Ye J, Zhang L, Li L
Biochimica et biophysica acta. Molecular basis of disease 2026 Jun;1872(5):168230

Kaiyujiangzhuo formula alleviates glycolipid metabolic disorders by improving arginine metabolism and inhibiting the ERK-mediated PPARγ-Ser273 phosphorylation.

Shi Y, Zhang Z, Lin H, Wang S, Wang D, Wu H, Qi H, Wang Y, Liu Q, Zhang Y, Xiong H, Ren J, Li X, Wang Z
Journal of ethnopharmacology 2026 Jun 12;364:121508

Taurine is a natural suppressor of urea cycle via targeting ASL.

Rao K, Zheng K, Sun Y, He J
Cell death discovery 2026 Feb 18;12(1):99

The Multitarget Compound ZLY032 Achieves Treatment of Chronic Wounds.

Gong M, Du Z, Gong T, Wang Y, Yin C, Sun B, Liu Z, Chen L, Liao Z, Wang W, Zhao T, Wang Y, Dong Y, Wang K, Ma M, Li W, Li J, Li H, Lin C, Zhang Y, Liu Y, Liu X, Ban T, Bao H, Zhang Y, Zhang Y, Li Z, Jiao L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e03098

Microneedles Loaded with Nitric-Oxide Driven Nanomotors Improve Force-Induced Efferocytosis Impairment and Sterile Inflammation by Revitalizing Macrophage Energy Metabolism.

Tan H, Wang S, He X, Yang G, Zhu Y, Yang S, Yan S, Gong C, Bai W, Hu Y, Song J, Zheng L
ACS nano 2025 Mar 11;19(9):9390-9411

Mitochondrial fumarate inhibits Parkin-mediated mitophagy.

Ham SJ, Bang S, Woo D, Jo JY, Yoo T, Yoon E, Kyoung Y, Baek D, Kim JS, Chung J
Molecular cell 2025 Jun 19;85(12):2287-2302.e9

Crataegus pinnatifida polysaccharide alleviates DSS-induced colitis in mice by regulating the intestinal microbiota and enhancing arginine biosynthesis.

Wei FH, Xie WY, Zhao PS, Ji ZH, Gao F, Chen CZ, Zhang Z, Gao W, Yuan B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156794

Metabolomics and proteomics reveal blocking argininosuccinate synthetase 1 alleviates colitis in mice.

Liu S, Sun H, Du Z, Lu S, Wang C, Zhang Y, Luo Z, Wang L, Fan Z, Wei P, Yan Y, Zhang J, Yin S, Liu T, He Q, Guo X, Ding K, Zhou J, Hua H, Yu C, Xu W, Shan J, Li Y, Xu Y, Shen X, Cao G, Zhou W
Nature communications 2025 Jul 30;16(1):6983

Lighting up arginine metabolism reveals its functional diversity in physiology and pathology.

Li R, Li Y, Jiang K, Zhang L, Li T, Zhao A, Zhang Z, Xia Y, Ge K, Chen Y, Wang C, Tang W, Liu S, Lin X, Song Y, Mei J, Xiao C, Wang A, Zou Y, Li X, Chen X, Ju Z, Jia W, Loscalzo J, Sun Y, Fang W, Yang Y, Zhao Y
Cell metabolism 2025 Jan 7;37(1):291-304.e9

Arginine Metabolism and Adenosine Receptor Signals in the Cerebellum Contribute to Nicotine Withdrawal-Induced Anxiety/Depression-Like Behaviours.

Zhang W, Tian Y, Yang X, He B, Zhang H, Zhang Q, Mei Y
Addiction biology 2025 Aug;30(8):e70076

TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential.

He J, Lin M, Zhang X, Zhang R, Tian T, Zhou Y, Dong W, Yang Y, Sun X, Dai Y, Xu Y, Zhang Z, Xu M, Lei QY, Xu Y, Lv L
Cell discovery 2023 Aug 8;9(1):84

Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin.

Head PE, Myung S, Chen Y, Schneller JL, Wang C, Duncan N, Hoffman P, Chang D, Gebremariam A, Gucek M, Manoli I, Venditti CP
Science translational medicine 2022 May 25;14(646):eabn4772

SWI/SNF complex subunit BAF60a represses hepatic ureagenesis through a crosstalk between YB-1 and PGC-1α.

Zhang W, Dong Z, Xu M, Zhang S, Liu C, Chen S
Molecular metabolism 2020 Feb;32:85-96

Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion.

Cao Y, Ding W, Zhang J, Gao Q, Yang H, Cao W, Wang Z, Fang L, Du R
Journal of proteome research 2019 May 3;18(5):2032-2044

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human liver tissue were subjected to SDS PAGE followed by western blot with 16645-1-AP(ASL antibody) at dilution of 1:500
Other comments: WB
Appendix: 16645-1-AP.pdf

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