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Protein structure
ASL
Argininosuccinate lyaseASAL
This gene encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Novus Biologicals |  H00000435-M01 |
2 references | Monoclonal |
WB
EL
ICC
IHC
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| Invitrogen Antibodies | PA5-22300 |
2 references | Polyclonal |
WB
ICC
IHC
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| GeneTex | GTX113629 |
1 references | Polyclonal |
WB
ICC
IHC
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| Atlas Antibodies | HPA016646 |
1 references | Polyclonal |
WB
IHC
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| LSBio | LS-C186321 |
Polyclonal |
WB
ICC
IHC
|
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