16488-1-AP

antibody from Proteintech Group

Targeting: VIL1 D2S1471, VIL

Provider product page for 16488-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [25]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 16488-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#16488-1-AP, RRID:AB_2215975
Product name: Villin antibody
Antibody type: Polyclonal
Description: Villin antibody (Cat. #16488-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

VIL1 protein structure - 16488-1-AP shown in red.

Submitted references JianPi QingRe HuoXue Formula targets Cadherin-17 to induce apoptosis in chronic atrophic gastritis with intestinal metaplasia.

Mai Z, Zheng Y, Xie J, Wen Y, Wang S, Huang Y, Tan H, Chen J, Wang C, Tao Y, Chen Q, Liu F, Liang Y, Chen X, Zhao Y, Li P, Yang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158037

Weiyan Tongluo Granules attenuate gastric intestinal metaplasia through PPARγ/NF-κB/CDX2 signaling pathway.

Liang Y, Su S, Jin T, Mou J, Wu H, Yan N, Li X, Yao S, Wen Y, Liu F, Li P
Chinese medicine 2026 Mar 4;21(1)

HFD-induced Alterations in Renal Tubular Oatp4c1-P-gp Transport Systems in Mice: Impact on Digoxin Renal Excretion and Gadolinium-Enhanced Radiological Manifestations.

Men J, Li J, Zhang T, Chen Y, Xu B, Hou H, Sun L, Yue H, Duan Z, Gui T, Gai Z
Current drug metabolism 2025;26(2):136-148

The supernatant of Lactiplantibacillus plantarum 25 is more effective than extracellular vesicles in alleviating ulcerative colitis and improving intestinal barrier function.

Gong S, Li X, Zhang Q, Wang R, Zeng R, Zhang Y
Frontiers in microbiology 2025;16:1742486

ZAKα Induces Pyroptosis of Colonic Epithelium Via the Caspase-11/GSDMD Pathway to Aggravate Colitis.

Li S, Chen M, Zheng S, Abudourexiti W, Zhu F, Wang Z, Guo Y, Yu Z, Yang Z, Zhang L, Ding C, Gong J
Inflammation 2025 Oct;48(5):3235-3251

Functional and morphological characterisation of human colonoid-derived monolayers under inflammatory conditions.

Parente IA, Chiara L, Flammini L, Viglioli M, Vacondio F, Gaiani F, de'Angelis GL, Pagano Mariano M, La Monica S, Barocelli E, Bertoni S
International journal of pharmaceutics 2025 Nov 30;685:126228

LACTB promotes cell differentiation and inhibits cell proliferation in colorectal cancer.

Ma L, Huang G, Lin C, Li X, Liu C, Huang W, Zhang Q, Luo Y
Biochimica et biophysica acta. General subjects 2025 Jul;1869(8):130816

Oral delivery of liquid mRNA therapeutics by an engineered capsule for treatment of preclinical intestinal disease.

Huang X, Liu C, Sharma SN, You X, Chen S, Li Y, Liu HJ, Liu B, Saiding Q, Chen W, Lee Y, Kong N, Abdi R, Tao W
Science translational medicine 2025 Jul 16;17(807):eadu1493

Yiqi Huayu Jiedu formula inhibits JAK2/STAT3-mediated partial EMT in treating chronic atrophic gastritis.

Yu W, Chen S, Guan X, He G, Zhang W, Zhang H, Huang S, Ye Z, Pan H, Zhong Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Feb;137:156356

Villin-1 regulates ferroptosis in colorectal cancer progression.

Hu B, Yin Y, Zhang B, Li S, Li K, Zhou Y, Huang Q
The FEBS journal 2025 Apr;292(7):1710-1725

ASB3 expression aggravates inflammatory bowel disease by targeting TRAF6 protein stability and affecting the intestinal microbiota.

Cheng M, Xu B, Sun Y, Wang J, Lu Y, Shi C, Pan T, Zhao W, Li X, Song X, Wang J, Wang N, Yang W, Jiang Y, Huang H, Yang G, Zeng Y, Yang D, Wang C, Cao X
mBio 2024 Sep 11;15(9):e0204324

Differentiation of intestinal stem cells toward goblet cells under systemic iron overload stress are associated with inhibition of Notch signaling pathway and ferroptosis.

Zhao J, Ma W, Wang S, Zhang K, Xiong Q, Li Y, Yu H, Du H
Redox biology 2024 Jun;72:103160

Human ITGAV variants are associated with immune dysregulation, brain abnormalities, and colitis.

Ghasempour S, Warner N, Guan R, Rodari MM, Ivanochko D, Whittaker Hawkins R, Marwaha A, Nowak JK, Liang Y, Mulder DJ, Stallard L, Li M, Yu DD, Pluthero FG, Batura V, Zhao M, Siddiqui I, Upton JEM, Hulst JM, Kahr WHA, Mendoza-Londono R, Charbit-Henrion F, Hoefsloot LH, Khiat A, Moreira D, Trindade E, Espinheira MDC, Pinto Pais I, Weerts MJA, Douben H, Kotlarz D, Snapper SB, Klein C, Dowling JJ, Julien JP, Joosten M, Cerf-Bensussan N, Freeman SA, Parlato M, van Ham TJ, Muise AM
The Journal of experimental medicine 2024 Dec 2;221(12)

Klebsiella pneumoniae Induces Inflammatory Bowel Disease Through Caspase-11-Mediated IL18 in the Gut Epithelial Cells.

Zhang Q, Su X, Zhang C, Chen W, Wang Y, Yang X, Liu D, Zhang Y, Yang R
Cellular and molecular gastroenterology and hepatology 2023;15(3):613-632

Maternal Folic Acid Supplementation Improves the Intestinal Health of Offspring Porcine by Promoting the Proliferation and Differentiation of Intestinal Stem Cells.

Zhang Y, Zhang X, Chen J, Jiang S, Han Y, Du H
Animals : an open access journal from MDPI 2023 Oct 3;13(19)

Bile acids-mediated intracellular cholesterol transport promotes intestinal cholesterol absorption and NPC1L1 recycling.

Xiao J, Dong LW, Liu S, Meng FH, Xie C, Lu XY, Zhang WJ, Luo J, Song BL
Nature communications 2023 Oct 13;14(1):6469

Elevated Protein Kinase A Activity in Stomach Mesenchyme Disrupts Mesenchymal-epithelial Crosstalk and Induces Preneoplasia.

Puri P, Grimmett G, Faraj R, Gibson L, Gilbreath E, Yoder BK
Cellular and molecular gastroenterology and hepatology 2022;14(3):643-668.e1

Bile acids promote the caveolae-associated entry of swine acute diarrhea syndrome coronavirus in porcine intestinal enteroids.

Yang QY, Yang YL, Tang YX, Qin P, Wang G, Xie JY, Chen SX, Ding C, Huang YW, Zhu SJ
PLoS pathogens 2022 Jun;18(6):e1010620

The Protective Effects of Apigenin Against Radiation-Induced Intestinal Injury.

Liu D, Peng R, Chen Z, Yu H, Wang S, Dong S, Li W, Shao W, Dai J, Li F, Jiang Q, Sun W
Dose-response : a publication of International Hormesis Society 2022 Jul-Sep;20(3):15593258221113791

Cathelicidin-WA Protects Against LPS-Induced Gut Damage Through Enhancing Survival and Function of Intestinal Stem Cells.

Wang S, Kai L, Zhu L, Xu B, Chen N, Valencak TG, Wang Y, Shan T
Frontiers in cell and developmental biology 2021;9:685363

NLRP3 inflammasome of renal tubular epithelial cells induces kidney injury in acute hemolytic transfusion reactions.

Liu Z, Chen Y, Niu B, Yin D, Feng F, Gu S, An Q, Xu J, An N, Zhang J, Yi J, Yin W, Qin X, Hu X
Clinical and translational medicine 2021 Mar;11(3):e373

Syntaxin 3 interacts with serotonin transporter and regulates its function.

Motoike S, Taguchi K, Harada K, Asano M, Hide I, Tanaka S, Irifune M, Sakai N
Journal of pharmacological sciences 2021 Apr;145(4):297-307

Survival and cellular heterogeneity of epithelium in cultured mouse and rat precision-cut intestinal slices.

Biel C, Bigaeva E, Hesse M, Bomers JJM, van Summeren K, Teunis MAT, Vaessen S, Ten Klooster JP, Olinga P
Toxicology in vitro : an international journal published in association with BIBRA 2020 Dec;69:104974

Nrf2-Knockout Protects from Intestinal Injuries in C57BL/6J Mice Following Abdominal Irradiation with γ Rays.

Yang W, Sun Z, Yang B, Wang Q
International journal of molecular sciences 2017 Jul 31;18(8)

Organotypic models of type III interferon-mediated protection from Zika virus infections at the maternal-fetal interface.

Corry J, Arora N, Good CA, Sadovsky Y, Coyne CB
Proceedings of the National Academy of Sciences of the United States of America 2017 Aug 29;114(35):9433-9438

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse kidney tissue were subjected to SDS PAGE followed by western blot with 16488-1-AP(VIL1 antibody) at dilution of 1:300
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Villin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Villin. This antibody recognizes human,mouse,rat antigen. The Villin antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 16488-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human small intestine using 16488-1-AP(VIL1 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue