orb386106

antibody from Biorbyt
Targeting: VIL1 D2S1471, VIL
Provider product page for orb386106
Western blot
Immunohistochemistry

Antibody data

Product number
orb386106 - Provider product page
Provider
Biorbyt
Product name
Villin Antibody
Antibody type
Monoclonal
Description
Villin (VIL1) is an epithelial cell-specific Ca2+-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. [UniProt]
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
VIL1/1325
Vial size
20 ug
Storage
Store the Villin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
VIL1 protein structure - orb386106 shown in red.