GRP

This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. The encoded preproprotein is proteolytically processed to generate two peptides, gastrin-releasing peptide and neuromedin-C. These peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

Description

Gastrin releasing peptide

Tissue specificity

Tissue enhanced (brain, lung, stomach)

Predicted location

Intracellular, Secreted in other tissues

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

18 (59220158 - 59230774)

Ensembl ID

ENSG00000134443  (ver. 103.38)

Orthologs

Mouse Grp: ENSMUSG00000024517

UniProt

P07492

neXtProt

NX_P07492

Human splice variants
Mouse splice variants

Protein structure