DUSP13

Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined. [provided by RefSeq, Jul 2008]

Description

Dual specificity phosphatase 13

Tissue specificity

Tissue enhanced (skeletal muscle, testis, tongue)

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

10 (75094432 - 75109221)

Ensembl ID

ENSG00000079393  (ver. 103.38)

Orthologs

Mouse Dusp13: ENSMUSG00000021768

UniProt

Q9UII6, Q6B8I1

neXtProt

NX_Q9UII6, NX_Q6B8I1

Human splice variants
Mouse splice variants

Protein structure