26196-1-AP

antibody from Proteintech Group

Targeting: GLP1R GLP-1R

Provider product page for 26196-1-AP

Western blot

ELISA

Antibody data

Antibody Data
Antigen structure
References [34]
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Product number: 26196-1-AP - Provider product page
Provider: Proteintech Group
Product name: GLP1R antibody
Antibody type: Polyclonal
Description: KD/KO validated GLP1R antibody (Cat. #26196-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

GLP1R protein structure - 26196-1-AP shown in red.

Submitted references Mo-Rubbing abdominal improves metabolic homeostasis in type 2 diabetes mellitus mice via a jejunum-specific GLP1-dependent mechanism.

Zhang Z, Gan L, Camille C, He X, Li L, Chen Y, Xu H, Hu J, Wei Q, Liu W, Wu Y
Diabetes, obesity & metabolism 2026 May;28(5):3819-3838

The engineered probiotic strain Lactococcus lactis MG1363-pMG36e-GLP-1 regulates microglial polarization and gut dysbiosis in a transgenic mouse model of Parkinson's disease.

Yue M, Chen T, Chen W, Wei J, Liao B, Zhang J, Li F, Hong D, Fang X
Neural regeneration research 2026 Mar 1;21(3):1211-1221

The promoting roles of GLP1R and GIPR in stemness maintenance and multiple lineage-specific differentiation of PDLSCs.

Shen Y, Zhang M, Yang T, Wu Y, Qiu Y, Zhang L, Li F, Chen M, Chen Q, Wei W, Li H, Shen Y
Cellular & molecular biology letters 2026 Feb 11;31(1):22

Sun X, Jia W, Liang H, Cheng H
Frontiers in immunology 2025;16:1481366

Gut microbiota regulation by Lactiplantibacillus plantarum SG5 enhances mitochondrial function in Parkinson's disease mice via the GLP-1/PGC-1α pathway.

Qi Y, Xie S, Chen J, Zhang C, Ma X, Yu Y, Yu X, Wang Y
The Journal of nutritional biochemistry 2025 Sep;143:109954

A Combination of Citrus Aurantifolia Fruit Rind and Theobroma cacao Seed Extracts Ameliorates Obesity in High-Fat Diet-Fed Rats via the AMPK Pathway.

Kim S, Kundimi S, Rao T, Veeramachaneni S, Ramanathan G, Koo YK
Journal of medicinal food 2025 Nov;28(11):1091-1100

Blueberry Anthocyanin Extracts (BAEs) Protect Retinal and Retinal Pigment Epithelium Function from High-Glucose-Induced Apoptosis by Activating GLP-1R/Akt Signaling.

Li R, Du S, Ye Z, Yang W, Liu Y
Journal of agricultural and food chemistry 2025 Mar 12;73(10):5886-5898

Lactiplantibacillus plantarum SG5 inhibits neuroinflammation in MPTP-induced PD mice through GLP-1/PGC-1α pathway.

Qi Y, Dong Y, Chen J, Xie S, Ma X, Yu X, Yu Y, Wang Y
Experimental neurology 2025 Jan;383:115001

Huanglian-Renshen-Decoction Maintains Islet β-Cell Identity in T2DM Mice through Regulating GLP-1 and GLP-1R in Both Islet and Intestine.

Wu WB, Gao F, Tang YH, Wang HZ, Dong H, Lu FE, Yuan F
Chinese journal of integrative medicine 2025 Jan;31(1):39-48

Gestational diabetes mellitus-derived miR-7-19488 targets PIK3R2 mRNA to stimulate the abnormal development and maturation of offspring-islets.

Xu C, Zou L, Wang L, Lv W, Cao X, Jia X, Wang Y, Jiang G, Ji L
Life sciences 2025 Feb 15;363:123369

Liraglutide modulates ALCAT1-Mediated cardiolipin remodeling to improve cardiac function in obese mice.

Wang L, Hu T, Zhang R, Shi Y, Wang Y, Xuan Q, Zhou X
Biochemical and biophysical research communications 2025 Apr 5;756:151583

A combination of Citrus aurantifolia fruit rind and Theobroma cacao seed extracts supplementation enhances metabolic rates in overweight subjects: a randomized, placebo-controlled, cross-over study.

Ammatalli NKR, Kuricheti SSSK, Veeramachaneni S, Koo YK, Ramanathan G, Yalamanchi A
Food & nutrition research 2024;68

Cardiometabolic Modulation by Semaglutide Contributes to Cardioprotection in Rats with Myocardial Infarction.

Yan H, Yao W, Li Y, Li T, Song K, Yan P, Dang Y
Drug design, development and therapy 2024;18:5485-5500

GLP-1R mediates idebenone-reduced blood glucose in mice.

Zhao X, Zeng Q, Yu S, Zhu X, Bin Hu, Deng L, Zhang Y, Liu Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117202

Gut Bacteroides ovatus ameliorates renal fibrosis by promoting the production of HDCA through upregulation of Clostridium scindens.

Si ZL, Wang HY, Wang T, Cao YZ, Li QZ, Liu K, Huang Z, Liu HL, Tan YJ, Wang YY, Huang FQ, Ma GX, Alolga RN, Yan M, Chen C, Li JH, Li J, Liu HW, Zhang ZH
Cell reports 2024 Oct 22;43(10):114830

Baicalein Ameliorates Insulin Resistance of HFD/STZ Mice Through Activating PI3K/AKT Signal Pathway of Liver and Skeletal Muscle in a GLP-1R-Dependent Manner.

Liu N, Cui X, Guo T, Wei X, Sun Y, Liu J, Zhang Y, Ma W, Yan W, Chen L
Antioxidants (Basel, Switzerland) 2024 Oct 16;13(10)

Effects of glucagon-like peptide-1 receptor agonists on spermatogenesis-related gene expression in mouse testis and testis-derived cell lines.

Iida M, Asano A
The Journal of veterinary medical science 2024 May 25;86(5):555-562

Affinity-Driven Aryl Diazonium Labeling of Peptide Receptors on Living Cells.

Sharma S, Naldrett MJ, Gill MJ, Checco JW
Journal of the American Chemical Society 2024 May 15;146(19):13676-13688

High glucose impairs cognitive function through inducing mitochondrial calcium overload in Treg cells.

Hui Y, Kuang L, Zhong Y, Tang Y, Xu Z, Zheng T
iScience 2024 Jan 19;27(1):108689

Human gestational diabetes mellitus-derived exosomes impair glucose homeostasis in pregnant mice and stimulate functional maturation of offspring-islets.

Zou L, Xu C, Wang L, Cao X, Jia X, Yang Z, Jiang G, Ji L
Life sciences 2024 Apr 1;342:122514

The Involvement of PGRMC1 Signaling in Cognitive Impairment Induced by Long-Term Clozapine Treatment in Rats.

Cao T, Wang L, Jiao S, Chen H, Lin C, Zhang B, Cai H
Neuropsychobiology 2023;82(6):346-358

Semaglutide inhibits ischemia/reperfusion-induced cardiomyocyte apoptosis through activating PKG/PKCε/ERK1/2 pathway.

Zhu Q, Luo Y, Wen Y, Wang D, Li J, Fan Z
Biochemical and biophysical research communications 2023 Mar 5;647:1-8

Liraglutide Attenuates Myocardial Ischemia/Reperfusion Injury Through the Inhibition of Necroptosis by Activating GLP-1R/PI3K/Akt Pathway.

Zhou G, Wu H, Yang J, Ye M, Liu D, Li Y, Zhang D, Zhang J, Yang Q, Liu Y
Cardiovascular toxicology 2023 Apr;23(3-4):161-175

Semaglutide May Alleviate Hepatic Steatosis in T2DM Combined with NFALD Mice via miR-5120/ABHD6.

Li R, Ye Z, She D, Fang P, Zong G, Hu K, Kong D, Xu W, Li L, Zhou Y, Zhang K, Xue Y
Drug design, development and therapy 2022;16:3557-3572

Neuroprotective effects of liraglutide against inflammation through the AMPK/NF-κB pathway in a mouse model of Parkinson's disease.

Cao B, Zhang Y, Chen J, Wu P, Dong Y, Wang Y
Metabolic brain disease 2022 Feb;37(2):451-462

Clozapine Induced Disturbances in Hepatic Glucose Metabolism: The Potential Role of PGRMC1 Signaling.

Cao T, Chen Q, Zhang B, Wu X, Zeng C, Zhang S, Cai H
Frontiers in endocrinology 2021;12:727371

Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist S6 Stimulates Insulin Secretion From Rat Islets.

Yang X, Zhang M, Lu Z, Zhi L, Xue H, Liu T, Liu M, Cui L, Liu Z, He P, Liu Y, Zhang Y
Frontiers in pharmacology 2021;12:664802

A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits.

Cao T, Tang M, Jiang P, Zhang B, Wu X, Chen Q, Zeng C, Li N, Zhang S, Cai H
Frontiers in pharmacology 2021;12:612083

Geniposide Improves Diabetic Nephropathy by Enhancing ULK1-Mediated Autophagy and Reducing Oxidative Stress through AMPK Activation.

Dusabimana T, Park EJ, Je J, Jeong K, Yun SP, Kim HJ, Kim H, Park SW
International journal of molecular sciences 2021 Feb 6;22(4)

Liraglutide, a glucagon-like peptide-1 receptor agonist, suppresses osteoclastogenesis through the inhibition of NF-κB and MAPK pathways via GLP-1R.

Li Z, Li S, Wang N, Xue P, Li Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110523

Liraglutide regulates proliferation, differentiation, and apoptosis of preosteoblasts through a signaling network of Notch/Wnt/Hedgehog signaling pathways.

Hou HW, Xue P, Wang Y, Li YK
European review for medical and pharmacological sciences 2020 Dec;24(23):12408-12422

Oxaliplatin reverses the GLP-1R-mediated promotion of intrahepatic cholangiocarcinoma by altering FoxO1 signaling.

Chen B, Zhou W, Zhao W, Yuan P, Tang C, Wang G, Leng J, Ma J, Wang X, Hui Y, Wang Q
Oncology letters 2019 Aug;18(2):1989-1998

Liraglutide inhibits the apoptosis of human nucleus pulposus cells induced by high glucose through PI3K/Akt/caspase-3 signaling pathway.

Ming-Yan Y, Jing Z, Shu-Qin G, Xiao-Liang B, Zhi-Hong L, Xue Z
Bioscience reports 2019 Aug 30;39(8)

AWRK6, a Novel GLP-1 Receptor Agonist, Attenuates Diabetes by Stimulating Insulin Secretion.

Wang Q, Zhao C, Jin L, Zhang H, Miao Q, Liu H, Zhang D
International journal of molecular sciences 2018 Oct 7;19(10)

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