GLP1R

This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

Description

Glucagon like peptide 1 receptor

Tissue specificity

Tissue enhanced (brain, heart muscle, pancreas)

Predicted location

Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

6 (39048781 - 39091303)

Ensembl ID

ENSG00000112164  (ver. 103.38)

Orthologs

Mouse Glp1r: ENSMUSG00000024027

UniProt

P43220

neXtProt

NX_P43220

Human splice variants
Mouse splice variants

Protein structure