16112-1-AP

antibody from Proteintech Group

Targeting: LPCAT1 AGPAT10, AGPAT9, AYTL2, FLJ12443

Provider product page for 16112-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [48]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 16112-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#16112-1-AP, RRID:AB_2135554
Product name: LPCAT1 antibody
Antibody type: Polyclonal
Description: KD/KO validated LPCAT1 antibody (Cat. #16112-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

LPCAT1 protein structure - 16112-1-AP shown in red.

Submitted references Reduction in Synaptic Vesicle Protein Abundance but Increased Amounts of Nsg2 and Lpcat1 in Cerebral Cortices Without the Endosomal SNARE Proteins Vti1a and Vti1b.

Gottschalk J, Kotschnew K, Hahn J, Patschkowski T, von Fischer von Mollard G
Proteomics 2026 May;26(5):86-97

Lysophosphatidylcholine acyltransferase 1 promotes head and neck squamous cell carcinoma progression by enhancing COX17-dependent oxidative phosphorylation.

Zhao Y, Li Y, Li Y, Wang Z, Liu C, Chen L, Wang M, Wang M, Cheng Z, Hu G, Pan M
Cell death discovery 2026 Mar 6;12(1)

Lysolecithin reprogramming via LPCAT1 modulation restores endothelial function and prevents diabetes-associated dysmetabolism.

Sommella EM, Iside C, Di Pietro P, Merciai F, Salviati E, Sala M, Abate AC, Damato A, De Lucia M, Venturini E, Prete V, Picone F, Poggio P, Mone P, Ciccarelli M, Santulli G, Campiglia P, Vecchione C, Carrizzo A
Cardiovascular diabetology 2026 Jan 18;25(1):45

HIF-2α/LPCAT1 orchestrates the reprogramming of lipid metabolism in ccRCC by modulating the FBXW7-mediated ubiquitination of ACLY.

Fei M, Zhang Y, Li H, Xu Q, Gao Y, Yang C, Li W, Liang C, Wang B, Xiao H
International journal of biological sciences 2025;21(2):614-631

Biomimetic nanoparticles coated with ScFv-modified macrophage membranes for siRNA delivery to relieve brain metastases of lung cancer.

Lu Y, Qiao Y, Wu T, Zhang Y, Shi J, Jiang J
BMC biotechnology 2025 Sep 2;25(1):97

Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation.

England FJ, Bordeu I, Ng ME, Bang J, Kim B, Choi J, Cardoso EC, Koo BK, Simons BD, Lee JH
Cell stem cell 2025 Mar 6;32(3):375-390.e9

LRRK2 reduces the sensitivity to TKI and PD-1 blockade in ccRCC via activating LPCAT1.

Hong Y, Li W, Xing Z, Lu M, Tang T, Zhu L, Xiong W, Zhang H, Liu W, Ren S
Oncogene 2025 Jun;44(22):1761-1776

Disorder of phospholipid metabolism in the renal cortex and medulla contributes to acute tubular necrosis in mice after cantharidin exposure using integrative lipidomics and spatial metabolomics.

He T, Lin K, Xiong L, Zhang W, Zhang H, Duan C, Li X, Zhang J
Journal of pharmaceutical analysis 2025 Jul;15(7):101210

LPCAT1, the Enzyme Responsible for Converting LPC to PC, Promotes OPC Differentiation In Vitro.

Shang Q, Zhang X, Pu Y, Lin J, Ma P, Pan Y, Zhao M, Sun D, Cao L
Journal of cellular and molecular medicine 2025 Feb;29(3):e70387

Lysophosphatidylcholine Acyltransferase 1-Phosphatidylcholine Axis Protects Nucleus Pulposus Cells From Ferroptosis by Facilitating Lysosomal Repair via Interaction With the Endoplasmic Reticulum.

Li C, Jiang J, Tu S, Dong Y, Zhang W, Chen X
Neurospine 2025 Dec;22(4):953-973

Leukemia-expanded splenic CD81+ erythroblasts potentiate disease progression in mice by reshaping leukemic cell metabolism.

Li Y, Cao J, Tong J, Tang P, Chen H, Sun G, Yang Z, Zhang X, Dong F, Yang S, Gao J, Zhao X, Ma J, Wang D, Zhang L, Wang L, Cheng T, Cheng H, Shi L
The Journal of clinical investigation 2025 Dec 15;135(24)

Multiomics analysis reveals the potential of LPCAT1-PC axis as a therapeutic target for human intervertebral disc degeneration.

Chen X, Chen K, Hu J, Dong Y, Zheng M, Hu Q, Zhang W
International journal of biological macromolecules 2024 Sep;276(Pt 1):133779

Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer.

Fowle-Grider R, Rowles JL 3rd, Shen I, Wang Y, Schwaiger-Haber M, Dunham AJ, Jayachandran K, Inkman M, Zahner M, Naser FJ, Jackstadt MM, Spalding JL, Chiang S, McCommis KS, Dolle RE, Kramer ET, Zimmerman SM, Souroullas GP, Finck BN, Shriver LP, Kaufman CK, Schwarz JK, Zhang J, Patti GJ
Nature 2024 Dec;636(8043):737-744

Comprehensive pancancer analysis reveals that LPCAT1 is a novel predictive biomarker for prognosis and immunotherapy response.

Gao H, Zhu J, Wu T, Long Q, Guan X, Chen Q, Yi W
Apoptosis : an international journal on programmed cell death 2024 Dec;29(11-12):2128-2146

Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency.

Wang P, Shao Y, Al-Nusaif M, Zhang J, Yang H, Yang Y, Kim K, Li S, Liu C, Cai H, Le W
Molecular neurodegeneration 2024 Aug 26;19(1):62

Anti-EGFR ScFv functionalized exosomes delivering LPCAT1 specific siRNAs for inhibition of lung cancer brain metastases.

Jiang J, Lu Y, Chu J, Zhang X, Xu C, Liu S, Wan Z, Wang J, Zhang L, Liu K, Liu Z, Yang A, Ren X, Zhang R
Journal of nanobiotechnology 2024 Apr 8;22(1):159

Identification of molecular subtypes based on PANoptosis-related genes and construction of a signature for predicting the prognosis and response to immunotherapy response in hepatocellular carcinoma.

Zhu J, Huang Q, Peng X, Luo C, Liu Z, Liu D, Yuan H, Yuan R, Cheng X
Frontiers in immunology 2023;14:1218661

The prognostic value of the GPAT/AGPAT gene family in hepatocellular carcinoma and its role in the tumor immune microenvironment.

Wen P, Wang R, Xing Y, Ouyang W, Yuan Y, Zhang S, Liu Y, Peng Z
Frontiers in immunology 2023;14:1026669

Upregulation of LPGAT1 Enhances Lung Adenocarcinoma Proliferation.

Gong H, Ma C, Li X, Zhang X, Zhang L, Chen P, Wang W, Hu Y, Huang T, Wu N, Wang X
Frontiers in bioscience (Landmark edition) 2023 May 11;28(5):89

Neonatal exposure to sevoflurane induces adolescent neurobehavioral dysfunction by interfering with hippocampal glycerophoslipid metabolism in rats.

Wang Y, Li H, Zhao Y, Qin F, Wang L, Jiang L, Wang X, Chen R, He Y, Wei Q, Li S, Chen Y, Xiao Y, Dai Y, Bu Q, Zhao Y, Tian J, Wang H, Cen X
Cerebral cortex (New York, N.Y. : 1991) 2023 Feb 20;33(5):1955-1971

Arginase 1 and L-arginine coordinate fetal lung development and the initiation of labor in mice.

Yu Y, Liu Y, Sui X, Sui Y, Wang Z, Mendelson CR, Gao L
EMBO reports 2023 Aug 3;24(8):e56352

The inhibition of Aurora A kinase regulates phospholipid remodeling by upregulating LPCAT1 in glioblastoma.

Miao YZ, Wang J, Hao SY, Deng YX, Zhang Z, Jin ZP, Liu DY, Zhang SD, Wan H, Ji N, Feng J
Neoplasma 2023 Apr;70(2):260-271

Novel Prognostic Signatures of Hepatocellular Carcinoma Based on Metabolic Pathway Phenotypes.

Ye T, Lin L, Cao L, Huang W, Wei S, Shan Y, Zhang Z
Frontiers in oncology 2022;12:863266

Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism.

Deng X, Hao C, Li Y, Guo Y, Si H, He J, Deng M, Niu Z, Wang C, Xu X, Dai K, Yao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113638

Polypeptide N-acetylgalactosaminyltransferase 18 retains in endoplasmic reticulum depending on its luminal regions interacting with ER resident UGGT1, PLOD3 and LPCAT1.

Jia W, Zou X, Xu Z, Bai L, Shan A, Li Y, Shi J, Yang F, Ding C, Narimatsu H, Zhang Y
Glycobiology 2021 Sep 9;31(8):947-958

Increased lysophosphatidylcholine acyltransferase 1 expression is unrelated to prognosis of esophageal cancer patients.

Bellon E, Grupp K, Ghadban T, Tachezy M, Bachmann K, Izbicki JR, Simon R, Sauter G, Hube-Magg C, Melling N
Journal of cancer research and clinical oncology 2021 Oct;147(10):2879-2884

Molecular mechanisms regulating lysophosphatidylcholine acyltransferase 1 (LPCAT1) in human pregnancy.

Purandare N, Minchella P, Somayajulu M, Kramer KJ, Zhou J, Adekoya N, Welch RA, Grossman LI, Aras S, Recanati MA
Placenta 2021 Mar;106:40-48

Chemical profile of Swertia mussotii Franch and its potential targets against liver fibrosis revealed by cross-platform metabolomics.

Zhang Y, Zhou Q, Ding X, Ma J, Tan G
Journal of ethnopharmacology 2021 Jun 28;274:114051

FGF9 and FGF10 activate distinct signaling pathways to direct lung epithelial specification and branching.

Yin Y, Ornitz DM
Science signaling 2020 Mar 3;13(621)

Alteration in Lysophospholipids and Converting Enzymes in Glaucomatous Optic Nerves.

Milbeck SM, Bhattacharya SK
Investigative ophthalmology & visual science 2020 Jun 3;61(6):60

Lysophosphatidylcholine acyltransferase 2 (LPCAT2) co-localises with TLR4 and regulates macrophage inflammatory gene expression in response to LPS.

Abate W, Alrammah H, Kiernan M, Tonks AJ, Jackson SK
Scientific reports 2020 Jun 25;10(1):10355

Regulation of stem cell function and neuronal differentiation by HERV-K via mTOR pathway.

Wang T, Medynets M, Johnson KR, Doucet-O'Hare TT, DiSanza B, Li W, Xu Y, Bagnell A, Tyagi R, Sampson K, Malik N, Steiner J, Hadegan A, Kowalak J, O'Malley J, Maric D, Nath A
Proceedings of the National Academy of Sciences of the United States of America 2020 Jul 28;117(30):17842-17853

Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling.

Bi J, Ichu TA, Zanca C, Yang H, Zhang W, Gu Y, Chowdhry S, Reed A, Ikegami S, Turner KM, Zhang W, Villa GR, Wu S, Quehenberger O, Yong WH, Kornblum HI, Rich JN, Cloughesy TF, Cavenee WK, Furnari FB, Cravatt BF, Mischel PS
Cell metabolism 2019 Sep 3;30(3):525-538.e8

Up-regulation of lysophosphatidylcholine acyltransferase 1 (LPCAT1) is linked to poor prognosis in breast cancer.

Lebok P, von Hassel A, Meiners J, Hube-Magg C, Simon R, Höflmayer D, Hinsch A, Dum D, Fraune C, Göbel C, Möller K, Sauter G, Jacobsen F, Büscheck F, Prien K, Krech T, Krech RH, von der Assen A, Wölber L, Witzel I, Schmalfeldt B, Geist S, Paluchoswski P, Wilke C, Heilenkötter U, Terracciano L, Müller V, Wilczak W, Burandt EC
Aging 2019 Sep 18;11(18):7796-7804

LPCAT1 promotes brain metastasis of lung adenocarcinoma by up-regulating PI3K/AKT/MYC pathway.

Wei C, Dong X, Lu H, Tong F, Chen L, Zhang R, Dong J, Hu Y, Wu G, Dong X
Journal of experimental & clinical cancer research : CR 2019 Feb 21;38(1):95

Lysophosphatidylcholine acyltransferase 1 upregulation and concomitant phospholipid alterations in clear cell renal cell carcinoma.

Du Y, Wang Q, Zhang X, Wang X, Qin C, Sheng Z, Yin H, Jiang C, Li J, Xu T
Journal of experimental & clinical cancer research : CR 2017 May 12;36(1):66

Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids.

Nikolić MZ, Caritg O, Jeng Q, Johnson JA, Sun D, Howell KJ, Brady JL, Laresgoiti U, Allen G, Butler R, Zilbauer M, Giangreco A, Rawlins EL
eLife 2017 Jun 30;6

Age-Associated Lipidome Changes in Metaphase II Mouse Oocytes.

Mok HJ, Shin H, Lee JW, Lee GK, Suh CS, Kim KP, Lim HJ
PloS one 2016;11(2):e0148577

Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate.

Laresgoiti U, Nikolić MZ, Rao C, Brady JL, Richardson RV, Batchen EJ, Chapman KE, Rawlins EL
Development (Cambridge, England) 2016 Oct 15;143(20):3686-3699

Overexpression of Lysophosphatidylcholine Acyltransferase 1 and Concomitant Lipid Alterations in Gastric Cancer.

Uehara T, Kikuchi H, Miyazaki S, Iino I, Setoguchi T, Hiramatsu Y, Ohta M, Kamiya K, Morita Y, Tanaka H, Baba S, Hayasaka T, Setou M, Konno H
Annals of surgical oncology 2016 Feb;23 Suppl 2:S206-13

Lysophosphatidylcholine acyltransferase1 overexpression promotes oral squamous cell carcinoma progression via enhanced biosynthesis of platelet-activating factor.

Shida-Sakazume T, Endo-Sakamoto Y, Unozawa M, Fukumoto C, Shimada K, Kasamatsu A, Ogawara K, Yokoe H, Shiiba M, Tanzawa H, Uzawa K
PloS one 2015;10(3):e0120143

Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Specifically Interacts with Phospholipid Transfer Protein StarD10 to Facilitate Surfactant Phospholipid Trafficking in Alveolar Type II Cells.

Lin S, Ikegami M, Moon C, Naren AP, Shannon JM
The Journal of biological chemistry 2015 Jul 24;290(30):18559-74

The expression of Toll-like receptor 4, 7 and co-receptors in neurochemical sub-populations of rat trigeminal ganglion sensory neurons.

Helley MP, Abate W, Jackson SK, Bennett JH, Thompson SW
Neuroscience 2015 Dec 3;310:686-98

Neutral lipid stores and lipase PNPLA5 contribute to autophagosome biogenesis.

Dupont N, Chauhan S, Arko-Mensah J, Castillo EF, Masedunskas A, Weigert R, Robenek H, Proikas-Cezanne T, Deretic V
Current biology : CB 2014 Mar 17;24(6):609-20

Effects of platelet-activating factor and its differential regulation by androgens and steroid hormones in prostate cancers.

Xu B, Gao L, Wang L, Tang G, He M, Yu Y, Ni X, Sun Y
British journal of cancer 2013 Sep 3;109(5):1279-86

High lysophosphatidylcholine acyltransferase 1 expression independently predicts high risk for biochemical recurrence in prostate cancers.

Grupp K, Sanader S, Sirma H, Simon R, Koop C, Prien K, Hube-Magg C, Salomon G, Graefen M, Heinzer H, Minner S, Izbicki JR, Sauter G, Schlomm T, Tsourlakis MC
Molecular oncology 2013 Dec;7(6):1001-11

Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression.

Morita Y, Sakaguchi T, Ikegami K, Goto-Inoue N, Hayasaka T, Hang VT, Tanaka H, Harada T, Shibasaki Y, Suzuki A, Fukumoto K, Inaba K, Murakami M, Setou M, Konno H
Journal of hepatology 2013 Aug;59(2):292-9

The expression level of lysophosphatidylcholine acyltransferase 1 (LPCAT1) correlates to the progression of prostate cancer.

Zhou X, Lawrence TJ, He Z, Pound CR, Mao J, Bigler SA
Experimental and molecular pathology 2012 Feb;92(1):105-10

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human lung tissue were subjected to SDS PAGE followed by western blot with 16112-1-AP(LPCAT1 antibody) at dilution of 1:4000
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of MCF-7 cells, using LPCAT1 antibody 16112-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human lung cancer using 16112-1-AP(LPCAT1 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human lung cancer using 16112-1-AP(LPCAT1 antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue