LPCAT1

This gene encodes a member of the 1-acyl-sn-glycerol-3-phosphate acyltransferase family of proteins. The encoded enzyme plays a role in phospholipid metabolism, specifically in the conversion of lysophosphatidylcholine to phosphatidylcholine in the presence of acyl-CoA. This process is important in the synthesis of lung surfactant and platelet-activating factor (PAF). Elevated expression of this gene may contribute to the progression of oral squamous cell, prostate, breast, and other human cancers. [provided by RefSeq, Sep 2016]

Description

Lysophosphatidylcholine acyltransferase 1

Tissue specificity

Tissue enhanced (lung, lymphoid tissue)

Subcell location

Endoplasmic reticulum, Lipid droplets

Predicted location

Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

5 (1456480 - 1523962)

Ensembl ID

ENSG00000153395  (ver. 103.38)

Orthologs

Mouse Lpcat1: ENSMUSG00000021608

UniProt

Q8NF37

neXtProt

NX_Q8NF37

Human splice variants
Mouse splice variants

Protein structure