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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Flow cytometry [1]
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- Product number
- 513008 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#513008, RRID:AB_11150407
- Product name
- APC anti-human IL-21
- Antibody type
- Monoclonal
- Antigen
- Recombinant full length human IL-21
- Description
- Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset, and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation, suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.
- Reactivity
- Human, Simian
- Host
- Mouse
- Conjugate
- Red dye
- Isotype
- IgG
- Vial size
- 100 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- PMA+ionomycin-stimulated (6 hours) human peripheral blood lymphocytes (in the presence of monensin) were intracellularly stained with IL-21(clone 3A3-N2) APC (top) or mouse IgG1 APC isotype control (bottom) and CD3 FITC.
- Conjugate
- Red dye
