Antibody data
- Antibody Data
- Antigen structure
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- Product number
- 514204 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#514204, RRID:AB_1227668
- Product name
- Biotin anti-human/mouse IL-21
- Antibody type
- Monoclonal
- Antigen
- Recombinant full length human IL-21
- Description
- Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces T(H)17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Biotin
- Isotype
- IgG
- Vial size
- 500 µg
- Concentration
- 0.5 mg/ml
- Storage
- Upon receipt, store frozen at 4°C.
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