Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 514303 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#514303, RRID:AB_2125168
- Product name
- Biotin anti-human/mouse IL-21
- Antibody type
- Monoclonal
- Antigen
- Recombinant full length human IL-21
- Description
- Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces T(H)17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Biotin
- Isotype
- IgG
- Vial size
- 50 µg
- Concentration
- 0.5 mg/ml
- Storage
- Upon receipt, store frozen at 4°C.
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Recombinant Human IL-21 (lane 1) and Mouse IL-21 (Lane 2) were resolved by electrophoresis, transferred to nitrocellulose, and probed with Biotin anti-HU/MU IL-21 Antibody (clone 7H20-I19-M3). Proteins were visualized using a Streptavidin conjugated to HRP and chemiluminscence detection.
- Conjugate
- Biotin