Antibody data
- Antibody Data
- Antigen structure
- References [31]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 14979-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14979-1-AP, RRID:AB_2136768
- Product name
- Galectin-3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Galectin-3 antibody (Cat. #14979-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus.
Lineage tracing reveals transient phenotypic adaptation of tubular cells during acute kidney injury.
A proteome-wide screen identifies the calcium binding proteins, S100A8/S100A9, as clinically relevant therapeutic targets in aortic dissection.
ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis.
Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia.
Targeting S100A9 Prevents β-Adrenergic Activation-Induced Cardiac Injury.
Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH.
RNF8 enhances the sensitivity of PD-L1 inhibitor against melanoma through ubiquitination of galectin-3 in stroma.
ST6GAL1 inhibits metastasis of hepatocellular carcinoma via modulating sialylation of MCAM on cell surface.
Proteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorption.
Hgs Deficiency Caused Restrictive Cardiomyopathy via Disrupting Proteostasis.
Prognostic Value and Biological Function of Galectins in Malignant Glioma.
A phosphoinositide signalling pathway mediates rapid lysosomal repair.
Galectin-3 inhibition boosts the therapeutic efficacy of Semliki Forest virus in pediatric osteosarcoma.
Sphingosine 1-phosphate receptor 2 promotes erythrocyte clearance by vascular smooth muscle cells in intraplaque hemorrhage through MFG-E8 production.
Substitution of the SERCA2 Cys(674) reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation.
Protection of CAPE-pNO(2) Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro.
Inhibition of galectin-3 ameliorates high-glucose-induced oxidative stress and inflammation in ARPE-19 cells.
Hepatic galectin-3 is associated with lipid droplet area in non-alcoholic steatohepatitis in a new swine model.
Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.
Galectin-3 Induces Atrial Fibrosis by Activating the TGF-β1/Smad Pathway in Patients with Atrial Fibrillation.
Assessment of mitochondrial function in metabolic dysfunction-associated fatty liver disease using obese mouse models.
Activation of Galectin-3 (LGALS3) Transcription by Injurious Stimuli in the Liver Is Commonly Mediated by BRG1.
Initial human T-cell leukemia virus type 1 infection of the salivary gland epithelial cells requires a biofilm-like structure.
Galectin-3 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension.
Synephrine Hydrochloride Suppresses Esophageal Cancer Tumor Growth and Metastatic Potential through Inhibition of Galectin-3-AKT/ERK Signaling.
Galectin-3 mediates pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension.
Galectin-3 mediates the pulmonary arterial hypertension-induced right ventricular remodeling through interacting with NADPH oxidase 4.
Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions.
Tongxinluo inhibits vascular inflammation and neointimal hyperplasia through blockade of the positive feedback loop between miR-155 and TNF-α.
Cell cycle arrest in a model of colistin nephrotoxicity.
Song Y, Jiang W, Afridi SK, Wang T, Zhu F, Xu H, Nazir FH, Liu C, Wang Y, Long Y, Huang YA, Qiu W, Tang C
Cell reports 2024 May 28;43(5):114226
Cell reports 2024 May 28;43(5):114226
Lineage tracing reveals transient phenotypic adaptation of tubular cells during acute kidney injury.
Buse M, Cheng M, Jankowski V, Lellig M, Sterzer V, Strieder T, Leuchtle K, Martin IV, Seikrit C, Brinkkoettter P, Crispatzu G, Floege J, Boor P, Speer T, Kramann R, Ostendorf T, Moeller MJ, Costa IG, Stamellou E
iScience 2024 Mar 15;27(3):109255
iScience 2024 Mar 15;27(3):109255
A proteome-wide screen identifies the calcium binding proteins, S100A8/S100A9, as clinically relevant therapeutic targets in aortic dissection.
Jiang H, Zhao Y, Su M, Sun L, Chen M, Zhang Z, Ilyas I, Wang Z, Little PJ, Wang L, Weng J, Ge J, Xu S
Pharmacological research 2024 Jan;199:107029
Pharmacological research 2024 Jan;199:107029
ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis.
Wan TT, Li Y, Li JX, Xiao X, Liu L, Li HH, Guo SB
Archives of biochemistry and biophysics 2024 Feb;752:109855
Archives of biochemistry and biophysics 2024 Feb;752:109855
Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia.
Sung W, Noh MY, Nahm M, Kim YS, Ki CS, Kim YE, Kim HJ, Kim SH
Journal of neuroinflammation 2024 Feb 13;21(1):47
Journal of neuroinflammation 2024 Feb 13;21(1):47
Targeting S100A9 Prevents β-Adrenergic Activation-Induced Cardiac Injury.
Liu J, Chen X, Zeng L, Zhang L, Wang F, Peng C, Huang X, Li S, Liu Y, Shou W, Li X, Cao D
Inflammation 2024 Apr;47(2):789-806
Inflammation 2024 Apr;47(2):789-806
Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH.
Itoh M, Tamura A, Kanai S, Tanaka M, Kanamori Y, Shirakawa I, Ito A, Oka Y, Hidaka I, Takami T, Honda Y, Maeda M, Saito Y, Murata Y, Matozaki T, Nakajima A, Kataoka Y, Ogi T, Ogawa Y, Suganami T
The Journal of experimental medicine 2023 Nov 6;220(11)
The Journal of experimental medicine 2023 Nov 6;220(11)
RNF8 enhances the sensitivity of PD-L1 inhibitor against melanoma through ubiquitination of galectin-3 in stroma.
Guo Y, Shen R, Yang K, Wang Y, Song H, Liu X, Cheng X, Wu R, Song Y, Wang D
Cell death discovery 2023 Jun 30;9(1):205
Cell death discovery 2023 Jun 30;9(1):205
ST6GAL1 inhibits metastasis of hepatocellular carcinoma via modulating sialylation of MCAM on cell surface.
Zou X, Lu J, Deng Y, Liu Q, Yan X, Cui Y, Xiao X, Fang M, Yang F, Sawaki H, Sato T, Tan B, Lu X, Feng B, Kuno A, Narimatsu H, Gao C, Zhang Y
Oncogene 2023 Feb;42(7):516-529
Oncogene 2023 Feb;42(7):516-529
Proteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorption.
Zhu L, Tang Y, Li XY, Kerk SA, Lyssiotis CA, Sun X, Wang Z, Cho JS, Ma J, Weiss SJ
The Journal of cell biology 2023 Apr 3;222(4)
The Journal of cell biology 2023 Apr 3;222(4)
Hgs Deficiency Caused Restrictive Cardiomyopathy via Disrupting Proteostasis.
Li Z, Wang T, Xin C, Song Y, Kong J, Xu J, Liu Q, Teng Y, Hou N, Cheng X, Yang G, Liu W, Zhou B, Zhang Y, Yang X, Wang J
International journal of biological sciences 2022;18(5):2018-2031
International journal of biological sciences 2022;18(5):2018-2031
Prognostic Value and Biological Function of Galectins in Malignant Glioma.
Zhu H, Liu D, Cheng L, Liu J, Wang G, Li H, Zhang Y, Mi H, Zhang S, Shu K, Yu X
Frontiers in oncology 2022;12:834307
Frontiers in oncology 2022;12:834307
A phosphoinositide signalling pathway mediates rapid lysosomal repair.
Tan JX, Finkel T
Nature 2022 Sep;609(7928):815-821
Nature 2022 Sep;609(7928):815-821
Galectin-3 inhibition boosts the therapeutic efficacy of Semliki Forest virus in pediatric osteosarcoma.
Herrador-Cañete G, Zalacain M, Labiano S, Laspidea V, Puigdelloses M, Marrodan L, Garcia-Moure M, Gonzalez-Huarriz M, Marco-Sanz J, Ausejo-Mauleon I, de la Nava D, Hernández-Osuna R, Martínez-García J, Silva-Pilipich N, Gurucega E, Patiño-García A, Hernández-Alcoceba R, Smerdou C, Alonso MM
Molecular therapy oncolytics 2022 Sep 15;26:246-264
Molecular therapy oncolytics 2022 Sep 15;26:246-264
Sphingosine 1-phosphate receptor 2 promotes erythrocyte clearance by vascular smooth muscle cells in intraplaque hemorrhage through MFG-E8 production.
Pan D, Wu W, Zuo G, Xie X, Li H, Ren X, Kong C, Zhou W, Zhang Z, Waterfall M, Chen S
Cellular signalling 2022 Oct;98:110419
Cellular signalling 2022 Oct;98:110419
Substitution of the SERCA2 Cys(674) reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation.
Su H, Mei Y, Luo S, Wu H, He Y, Shiraishi Y, Hu P, Cohen RA, Tong X
British journal of pharmacology 2022 Oct;179(20):4778-4791
British journal of pharmacology 2022 Oct;179(20):4778-4791
Protection of CAPE-pNO(2) Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro.
Wan Q, Zhang L, Zhou Q, Han Y, Li Z, Li B
Inflammation 2022 Jun;45(3):1039-1058
Inflammation 2022 Jun;45(3):1039-1058
Inhibition of galectin-3 ameliorates high-glucose-induced oxidative stress and inflammation in ARPE-19 cells.
Li M, Tian M, Jiang X, Liu Y, Wang Y, Li Y
Cutaneous and ocular toxicology 2022 Jun;41(2):179-186
Cutaneous and ocular toxicology 2022 Jun;41(2):179-186
Hepatic galectin-3 is associated with lipid droplet area in non-alcoholic steatohepatitis in a new swine model.
Herrera-Marcos LV, Martínez-Beamonte R, Macías-Herranz M, Arnal C, Barranquero C, Puente-Lanzarote JJ, Gascón S, Herrero-Continente T, Gonzalo-Romeo G, Alastrué-Vera V, Gutiérrez-Blázquez D, Lou-Bonafonte JM, Surra JC, Rodríguez-Yoldi MJ, García-Gil A, Güemes A, Osada J
Scientific reports 2022 Jan 19;12(1):1024
Scientific reports 2022 Jan 19;12(1):1024
Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.
Sun Z, Zhang L, Li L, Shao C, Liu J, Zhou M, Wang Z
American journal of physiology. Heart and circulatory physiology 2021 Jan 1;320(1):H364-H380
American journal of physiology. Heart and circulatory physiology 2021 Jan 1;320(1):H364-H380
Galectin-3 Induces Atrial Fibrosis by Activating the TGF-β1/Smad Pathway in Patients with Atrial Fibrillation.
Xiao M, Zhang M, Bie M, Wang X, Guo J, Xiao H
Cardiology 2020;145(7):446-455
Cardiology 2020;145(7):446-455
Assessment of mitochondrial function in metabolic dysfunction-associated fatty liver disease using obese mouse models.
Zhao QY, Ge LH, Zhang K, Chen HF, Zhan XX, Yang Y, Dang QL, Zheng Y, Zhou HB, Lyu JX, Fang HZ
Zoological research 2020 Sep 18;41(5):539-551
Zoological research 2020 Sep 18;41(5):539-551
Activation of Galectin-3 (LGALS3) Transcription by Injurious Stimuli in the Liver Is Commonly Mediated by BRG1.
Li Z, Lv F, Dai C, Wang Q, Jiang C, Fang M, Xu Y
Frontiers in cell and developmental biology 2019;7:310
Frontiers in cell and developmental biology 2019;7:310
Initial human T-cell leukemia virus type 1 infection of the salivary gland epithelial cells requires a biofilm-like structure.
Nakamura H, Shimizu T, Takatani A, Suematsu T, Nakamura T, Kawakami A
Virus research 2019 Aug;269:197643
Virus research 2019 Aug;269:197643
Galectin-3 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension.
Li T, Zha L, Luo H, Li S, Zhao L, He J, Li X, Qi Q, Liu Y, Yu Z
Aging and disease 2019 Aug;10(4):731-745
Aging and disease 2019 Aug;10(4):731-745
Synephrine Hydrochloride Suppresses Esophageal Cancer Tumor Growth and Metastatic Potential through Inhibition of Galectin-3-AKT/ERK Signaling.
Xu WW, Zheng CC, Huang YN, Chen WY, Yang QS, Ren JY, Wang YM, He QY, Liao HX, Li B
Journal of agricultural and food chemistry 2018 Sep 5;66(35):9248-9258
Journal of agricultural and food chemistry 2018 Sep 5;66(35):9248-9258
Galectin-3 mediates pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension.
Luo H, Liu B, Zhao L, He J, Li T, Zha L, Li X, Qi Q, Liu Y, Yu Z
Journal of the American Society of Hypertension : JASH 2017 Oct;11(10):673-683.e3
Journal of the American Society of Hypertension : JASH 2017 Oct;11(10):673-683.e3
Galectin-3 mediates the pulmonary arterial hypertension-induced right ventricular remodeling through interacting with NADPH oxidase 4.
He J, Li X, Luo H, Li T, Zhao L, Qi Q, Liu Y, Yu Z
Journal of the American Society of Hypertension : JASH 2017 May;11(5):275-289.e2
Journal of the American Society of Hypertension : JASH 2017 May;11(5):275-289.e2
Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions.
Martins R, Maier J, Gorki AD, Huber KV, Sharif O, Starkl P, Saluzzo S, Quattrone F, Gawish R, Lakovits K, Aichinger MC, Radic-Sarikas B, Lardeau CH, Hladik A, Korosec A, Brown M, Vaahtomeri K, Duggan M, Kerjaschki D, Esterbauer H, Colinge J, Eisenbarth SC, Decker T, Bennett KL, Kubicek S, Sixt M, Superti-Furga G, Knapp S
Nature immunology 2016 Dec;17(12):1361-1372
Nature immunology 2016 Dec;17(12):1361-1372
Tongxinluo inhibits vascular inflammation and neointimal hyperplasia through blockade of the positive feedback loop between miR-155 and TNF-α.
Zhang RN, Zheng B, Li LM, Zhang J, Zhang XH, Wen JK
American journal of physiology. Heart and circulatory physiology 2014 Aug 15;307(4):H552-62
American journal of physiology. Heart and circulatory physiology 2014 Aug 15;307(4):H552-62
Cell cycle arrest in a model of colistin nephrotoxicity.
Eadon MT, Hack BK, Alexander JJ, Xu C, Dolan ME, Cunningham PN
Physiological genomics 2013 Oct 1;45(19):877-88
Physiological genomics 2013 Oct 1;45(19):877-88
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 14979-1-AP(Galectin 3 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-Galectin 3 (IP:14979-1-AP, 3ug; Detection:14979-1-AP 1:500) with MCF-7 cells lysate 1600ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 14979-1-AP(Galectin 3 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Galectin 3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Galectin 3. This antibody recognizes human,mouse,rat antigen. The Galectin 3 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.