Antibody data
- Antibody Data
- Antigen structure
- References [64]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
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- Product number
- 14979-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14979-1-AP, RRID:AB_2136768
- Product name
- Galectin-3 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Galectin-3 antibody (Cat. #14979-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Targeting Apolipoprotein E4 rescues photoreceptor degeneration by inhibiting the disease-associated microglia activation in experimental retinal detachment.
Overcoming lysosomal barrier via V-ATPase: an exosome-based co-delivery platform for combined chemo/RNAi therapy against breast cancer.
Decoding microglial metabolic cell death and PANoptosis hub genes in subacute phase of traumatic brain injury: a multi-omics and experimental validation study.
A Type I/II Photosensitizer with Lysosome-Targeting Capabilities Induces Immunogenic Cell Death in Cancer Cells to Enhance Tumor Immunotherapy.
Cathepsin B regulated via TFEB and lysosomal membrane permeabilization in adipose tissue macrophages aggravates obesity-related severe acute pancreatitis.
Early Transcriptomic and Pathologic Changes of Col8a2 Mutant Fuchs Endothelial Corneal Dystrophy.
An endovascular porcine model of abdominal aortic aneurysm for interventional radiology research.
Redox switch C674 in SERCA2 triggers Ca(2+)-calcineurin-MCU-Drp1 cascade and pulmonary vascular remodeling.
Lysosome-Acidifying Nanoparticles Rescue A30P α-Synuclein Induced Neuronal Death in Cellular and Drosophila Models of Parkinson's Disease.
Structural properties of two glycans in the fruits of jujube and their regulation effect of M1-type and M2-type macrophage.
An integrative pharmacology-based study on the pharmacological activity and mechanism of xiaoji-chenpi formula (XCF) against MAFLD.
Arylsulfatase K attenuates airway epithelial cell senescence in COPD by regulating parkin-mediated mitophagy.
Dysfunctional Chondroitin 4-O-Sulfotransferase-1 Impairs Cellular Redox State and Promotes Tau Aggregation.
Dual-Targeted Biomimetic Nanoparticles for Enhanced Delivery of Polyphyllin B Synergistically Induce Ferroptosis and Immunogenic Cell Death in Gastric Cancer.
The compound (E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease.
Advanced N-glycoproteomics and proteomics approach revealed sexually dimorphic molecular signatures in primary mouse hepatocyte.
TFEB Orchestrates Stress Recovery and Paves the Way for Senescence Induction in Human Dermal Fibroblasts.
SPON2 facilitates osteosarcoma development by inducing M2 macrophage polarization through activation of the NF-κB/VEGF signaling axis.
N6-methyladenosine-modification of USP15 regulates chemotherapy resistance by inhibiting LGALS3 ubiquitin-mediated degradation via AKT/mTOR signaling activation pathway in hepatocellular carcinoma.
NFE2-driven neutrophil polarization promotes pancreatic cancer liver metastasis progression.
Overcoming ELDR-mediated cancer cell survival in vitro and in vivo via sphingomyelin-driven TRPML1 inactivation and TFEB suppression through lysosomal HSP70 targeting.
Spatial metabolomics revealed mTOR-mediated gastric epithelial repair by licorice (G. inflata) flavonoids.
Autophagy-dependent secretion of ENO1 mediates chemoresistance of glioblastoma and tumor microenvironment remodeling.
Inhibition of PLA2G4A attenuated valproic acid- induced lysosomal membrane permeabilization and restored impaired autophagic flux: Implications for hepatotoxicity.
GL-V9 Promotes Autophagy-Mediated YAP1 Degradation and Activates Mitochondrial Apoptosis in PDAC Cells.
CBR-470-1 protects against cardiomyocyte death in ischaemia/reperfusion injury by activating the Nrf2-GPX4 cascade.
Non-Sugar Sweetener Rubusoside Alleviates Lipid Metabolism Disorder In Vivo and In Vitro by Targeting PPARγ/α, Lgals3, and Mknk2.
Compound (E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one downregulation of Galectin-3 ameliorates Aβ pathogenesis-induced neuroinflammation in 5 × FAD mice.
Multi-model analysis of gallbladder cancer reveals the role of OxLDL-absorbing neutrophils in promoting liver invasion.
Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus.
Mycobacterial CpsA activates type I IFN signaling in macrophages via cGAS-mediated pathway.
Lineage tracing reveals transient phenotypic adaptation of tubular cells during acute kidney injury.
A proteome-wide screen identifies the calcium binding proteins, S100A8/S100A9, as clinically relevant therapeutic targets in aortic dissection.
ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis.
Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia.
Cathepsin C from extracellular histone-induced M1 alveolar macrophages promotes NETosis during lung ischemia-reperfusion injury.
Targeting S100A9 Prevents β-Adrenergic Activation-Induced Cardiac Injury.
Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH.
RNF8 enhances the sensitivity of PD-L1 inhibitor against melanoma through ubiquitination of galectin-3 in stroma.
ST6GAL1 inhibits metastasis of hepatocellular carcinoma via modulating sialylation of MCAM on cell surface.
Proteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorption.
Hgs Deficiency Caused Restrictive Cardiomyopathy via Disrupting Proteostasis.
Prognostic Value and Biological Function of Galectins in Malignant Glioma.
A phosphoinositide signalling pathway mediates rapid lysosomal repair.
Galectin-3 inhibition boosts the therapeutic efficacy of Semliki Forest virus in pediatric osteosarcoma.
Sphingosine 1-phosphate receptor 2 promotes erythrocyte clearance by vascular smooth muscle cells in intraplaque hemorrhage through MFG-E8 production.
Substitution of the SERCA2 Cys(674) reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation.
FASN promotes lymph node metastasis in cervical cancer via cholesterol reprogramming and lymphangiogenesis.
Protection of CAPE-pNO(2) Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro.
Modified citrus pectin inhibits breast cancer development in mice by targeting tumor-associated macrophage survival and polarization in hypoxic microenvironment.
Inhibition of galectin-3 ameliorates high-glucose-induced oxidative stress and inflammation in ARPE-19 cells.
Hepatic galectin-3 is associated with lipid droplet area in non-alcoholic steatohepatitis in a new swine model.
Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.
Galectin-3 Induces Atrial Fibrosis by Activating the TGF-β1/Smad Pathway in Patients with Atrial Fibrillation.
Assessment of mitochondrial function in metabolic dysfunction-associated fatty liver disease using obese mouse models.
Activation of Galectin-3 (LGALS3) Transcription by Injurious Stimuli in the Liver Is Commonly Mediated by BRG1.
Initial human T-cell leukemia virus type 1 infection of the salivary gland epithelial cells requires a biofilm-like structure.
Galectin-3 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension.
Synephrine Hydrochloride Suppresses Esophageal Cancer Tumor Growth and Metastatic Potential through Inhibition of Galectin-3-AKT/ERK Signaling.
Galectin-3 mediates pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension.
Galectin-3 mediates the pulmonary arterial hypertension-induced right ventricular remodeling through interacting with NADPH oxidase 4.
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Spatial metabolomics revealed mTOR-mediated gastric epithelial repair by licorice (G. inflata) flavonoids.
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Cell death & disease 2025 Dec 6;17(1):79
Inhibition of PLA2G4A attenuated valproic acid- induced lysosomal membrane permeabilization and restored impaired autophagic flux: Implications for hepatotoxicity.
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Biochemical pharmacology 2024 Sep;227:116438
GL-V9 Promotes Autophagy-Mediated YAP1 Degradation and Activates Mitochondrial Apoptosis in PDAC Cells.
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CBR-470-1 protects against cardiomyocyte death in ischaemia/reperfusion injury by activating the Nrf2-GPX4 cascade.
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Non-Sugar Sweetener Rubusoside Alleviates Lipid Metabolism Disorder In Vivo and In Vitro by Targeting PPARγ/α, Lgals3, and Mknk2.
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Compound (E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one downregulation of Galectin-3 ameliorates Aβ pathogenesis-induced neuroinflammation in 5 × FAD mice.
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Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus.
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Cell reports 2024 May 28;43(5):114226
Cell reports 2024 May 28;43(5):114226
Mycobacterial CpsA activates type I IFN signaling in macrophages via cGAS-mediated pathway.
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A proteome-wide screen identifies the calcium binding proteins, S100A8/S100A9, as clinically relevant therapeutic targets in aortic dissection.
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Pharmacological research 2024 Jan;199:107029
Pharmacological research 2024 Jan;199:107029
ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis.
Wan TT, Li Y, Li JX, Xiao X, Liu L, Li HH, Guo SB
Archives of biochemistry and biophysics 2024 Feb;752:109855
Archives of biochemistry and biophysics 2024 Feb;752:109855
Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia.
Sung W, Noh MY, Nahm M, Kim YS, Ki CS, Kim YE, Kim HJ, Kim SH
Journal of neuroinflammation 2024 Feb 13;21(1):47
Journal of neuroinflammation 2024 Feb 13;21(1):47
Cathepsin C from extracellular histone-induced M1 alveolar macrophages promotes NETosis during lung ischemia-reperfusion injury.
Yu J, Fu Y, Gao J, Zhang Q, Zhang N, Zhang Z, Jiang X, Chen C, Wen Z
Redox biology 2024 Aug;74:103231
Redox biology 2024 Aug;74:103231
Targeting S100A9 Prevents β-Adrenergic Activation-Induced Cardiac Injury.
Liu J, Chen X, Zeng L, Zhang L, Wang F, Peng C, Huang X, Li S, Liu Y, Shou W, Li X, Cao D
Inflammation 2024 Apr;47(2):789-806
Inflammation 2024 Apr;47(2):789-806
Lysosomal cholesterol overload in macrophages promotes liver fibrosis in a mouse model of NASH.
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The Journal of experimental medicine 2023 Nov 6;220(11)
The Journal of experimental medicine 2023 Nov 6;220(11)
RNF8 enhances the sensitivity of PD-L1 inhibitor against melanoma through ubiquitination of galectin-3 in stroma.
Guo Y, Shen R, Yang K, Wang Y, Song H, Liu X, Cheng X, Wu R, Song Y, Wang D
Cell death discovery 2023 Jun 30;9(1):205
Cell death discovery 2023 Jun 30;9(1):205
ST6GAL1 inhibits metastasis of hepatocellular carcinoma via modulating sialylation of MCAM on cell surface.
Zou X, Lu J, Deng Y, Liu Q, Yan X, Cui Y, Xiao X, Fang M, Yang F, Sawaki H, Sato T, Tan B, Lu X, Feng B, Kuno A, Narimatsu H, Gao C, Zhang Y
Oncogene 2023 Feb;42(7):516-529
Oncogene 2023 Feb;42(7):516-529
Proteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorption.
Zhu L, Tang Y, Li XY, Kerk SA, Lyssiotis CA, Sun X, Wang Z, Cho JS, Ma J, Weiss SJ
The Journal of cell biology 2023 Apr 3;222(4)
The Journal of cell biology 2023 Apr 3;222(4)
Hgs Deficiency Caused Restrictive Cardiomyopathy via Disrupting Proteostasis.
Li Z, Wang T, Xin C, Song Y, Kong J, Xu J, Liu Q, Teng Y, Hou N, Cheng X, Yang G, Liu W, Zhou B, Zhang Y, Yang X, Wang J
International journal of biological sciences 2022;18(5):2018-2031
International journal of biological sciences 2022;18(5):2018-2031
Prognostic Value and Biological Function of Galectins in Malignant Glioma.
Zhu H, Liu D, Cheng L, Liu J, Wang G, Li H, Zhang Y, Mi H, Zhang S, Shu K, Yu X
Frontiers in oncology 2022;12:834307
Frontiers in oncology 2022;12:834307
A phosphoinositide signalling pathway mediates rapid lysosomal repair.
Tan JX, Finkel T
Nature 2022 Sep;609(7928):815-821
Nature 2022 Sep;609(7928):815-821
Galectin-3 inhibition boosts the therapeutic efficacy of Semliki Forest virus in pediatric osteosarcoma.
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Molecular therapy oncolytics 2022 Sep 15;26:246-264
Molecular therapy oncolytics 2022 Sep 15;26:246-264
Sphingosine 1-phosphate receptor 2 promotes erythrocyte clearance by vascular smooth muscle cells in intraplaque hemorrhage through MFG-E8 production.
Pan D, Wu W, Zuo G, Xie X, Li H, Ren X, Kong C, Zhou W, Zhang Z, Waterfall M, Chen S
Cellular signalling 2022 Oct;98:110419
Cellular signalling 2022 Oct;98:110419
Substitution of the SERCA2 Cys(674) reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation.
Su H, Mei Y, Luo S, Wu H, He Y, Shiraishi Y, Hu P, Cohen RA, Tong X
British journal of pharmacology 2022 Oct;179(20):4778-4791
British journal of pharmacology 2022 Oct;179(20):4778-4791
FASN promotes lymph node metastasis in cervical cancer via cholesterol reprogramming and lymphangiogenesis.
Du Q, Liu P, Zhang C, Liu T, Wang W, Shang C, Wu J, Liao Y, Chen Y, Huang J, Tan H, Zhao Y, Xia M, Liu J, Yao S
Cell death & disease 2022 May 21;13(5):488
Cell death & disease 2022 May 21;13(5):488
Protection of CAPE-pNO(2) Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro.
Wan Q, Zhang L, Zhou Q, Han Y, Li Z, Li B
Inflammation 2022 Jun;45(3):1039-1058
Inflammation 2022 Jun;45(3):1039-1058
Modified citrus pectin inhibits breast cancer development in mice by targeting tumor-associated macrophage survival and polarization in hypoxic microenvironment.
Wang L, Zhao L, Gong FL, Sun C, Du DD, Yang XX, Guo XL
Acta pharmacologica Sinica 2022 Jun;43(6):1556-1567
Acta pharmacologica Sinica 2022 Jun;43(6):1556-1567
Inhibition of galectin-3 ameliorates high-glucose-induced oxidative stress and inflammation in ARPE-19 cells.
Li M, Tian M, Jiang X, Liu Y, Wang Y, Li Y
Cutaneous and ocular toxicology 2022 Jun;41(2):179-186
Cutaneous and ocular toxicology 2022 Jun;41(2):179-186
Hepatic galectin-3 is associated with lipid droplet area in non-alcoholic steatohepatitis in a new swine model.
Herrera-Marcos LV, Martínez-Beamonte R, Macías-Herranz M, Arnal C, Barranquero C, Puente-Lanzarote JJ, Gascón S, Herrero-Continente T, Gonzalo-Romeo G, Alastrué-Vera V, Gutiérrez-Blázquez D, Lou-Bonafonte JM, Surra JC, Rodríguez-Yoldi MJ, García-Gil A, Güemes A, Osada J
Scientific reports 2022 Jan 19;12(1):1024
Scientific reports 2022 Jan 19;12(1):1024
Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.
Sun Z, Zhang L, Li L, Shao C, Liu J, Zhou M, Wang Z
American journal of physiology. Heart and circulatory physiology 2021 Jan 1;320(1):H364-H380
American journal of physiology. Heart and circulatory physiology 2021 Jan 1;320(1):H364-H380
Galectin-3 Induces Atrial Fibrosis by Activating the TGF-β1/Smad Pathway in Patients with Atrial Fibrillation.
Xiao M, Zhang M, Bie M, Wang X, Guo J, Xiao H
Cardiology 2020;145(7):446-455
Cardiology 2020;145(7):446-455
Assessment of mitochondrial function in metabolic dysfunction-associated fatty liver disease using obese mouse models.
Zhao QY, Ge LH, Zhang K, Chen HF, Zhan XX, Yang Y, Dang QL, Zheng Y, Zhou HB, Lyu JX, Fang HZ
Zoological research 2020 Sep 18;41(5):539-551
Zoological research 2020 Sep 18;41(5):539-551
Activation of Galectin-3 (LGALS3) Transcription by Injurious Stimuli in the Liver Is Commonly Mediated by BRG1.
Li Z, Lv F, Dai C, Wang Q, Jiang C, Fang M, Xu Y
Frontiers in cell and developmental biology 2019;7:310
Frontiers in cell and developmental biology 2019;7:310
Initial human T-cell leukemia virus type 1 infection of the salivary gland epithelial cells requires a biofilm-like structure.
Nakamura H, Shimizu T, Takatani A, Suematsu T, Nakamura T, Kawakami A
Virus research 2019 Aug;269:197643
Virus research 2019 Aug;269:197643
Galectin-3 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension.
Li T, Zha L, Luo H, Li S, Zhao L, He J, Li X, Qi Q, Liu Y, Yu Z
Aging and disease 2019 Aug;10(4):731-745
Aging and disease 2019 Aug;10(4):731-745
Synephrine Hydrochloride Suppresses Esophageal Cancer Tumor Growth and Metastatic Potential through Inhibition of Galectin-3-AKT/ERK Signaling.
Xu WW, Zheng CC, Huang YN, Chen WY, Yang QS, Ren JY, Wang YM, He QY, Liao HX, Li B
Journal of agricultural and food chemistry 2018 Sep 5;66(35):9248-9258
Journal of agricultural and food chemistry 2018 Sep 5;66(35):9248-9258
Galectin-3 mediates pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension.
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Physiological genomics 2013 Oct 1;45(19):877-88
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 14979-1-AP(Galectin 3 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- IP Result of anti-Galectin 3 (IP:14979-1-AP, 3ug; Detection:14979-1-AP 1:500) with MCF-7 cells lysate 1600ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 14979-1-AP(Galectin 3 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The Galectin 3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Galectin 3. This antibody recognizes human,mouse,rat antigen. The Galectin 3 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.